Imminent angiotensin-converting enzyme inhibitor from microbial source for cancer therapy

Ebrahimi, Lida; Ai, Jafar; Alizadeh, Ali; Shariaty, Mehrdad

doi:10.4103/ijpvm.ijpvm_324_16

Cited by 9 publications

(9 citation statements)

References 35 publications

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“…It may be a potential therapeutic drug and need researches to test and verify. However, for Angiotensin Converting Enzyme (ACE)-Inhibitory, whether it has an anti-tumor effect is still unclear, some recent studies had demonstrated that Angiotensin Converting Enzyme (ACE) Inhibitory could induce apoptosis of cancer cell 69,70 . But some studies also demonstrated that it might increase the risk of canceryy 71 .…”

Section: Discussionmentioning

confidence: 99%

Construct a circRNA/miRNA/mRNA regulatory network to explore potential pathogenesis and therapy options of clear cell renal cell carcinoma

Bai

Yan

et al. 2020

Sci Rep

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clear cell renal cell carcinoma (ccRcc) is the most representative subtype of renal cancer. circRnA acts as a kind of ceRnA to play a role in regulating microRnA (miRnA) in many cancers. However, the potential pathogenesis role of the regulatory network among circRnA/miRnA/mRnA is not clear and has not been fully explored. CircRNA expression profile data were obtained from GEO datasets, and the differentially expressed circRNAs (DECs) were identified through utilizing R package (Limma) firstly. Secondly, miRNAs that were regulated by these circRNAs were predicted by using Cancerspecific circRNA database and Circular RNA Interactome. Thirdly, some related genes were identified by intersecting targeted genes, which was predicted by a web tool (miRWalk) and differentially expressed genes, which was obtained from TCGA datasets. Function enrichment was analyzed, and a PPI network was constructed by Cytoscape software and DAVID web set. Subsequently, ten hub-genes were screened from the network, and the overall survival time in patients of ccRcc with abnormal expression of these hub-genes were completed by GEPIA web set. In the last, a circRNA/miRNA/ mRnA regulatory network was constructed, and potential compounds and drug which may have the function of anti ccRCC were forecasted by taking advantage of CMap and PharmGKB datasets. Six DECs (hsa_circ_0029340, hsa_circ_0039238, hsa_circ_0031594, hsa_circ_0084927, hsa_circ_0035442, hsa_circ_0025135) were obtained and six miRNAs (miR-1205, miR-657, miR-587, miR-637, miR-1278, miR-548p) which are regulated by three circRNAs (hsa_circ_0084927, hsa_circ_0035442, hsa_ circ_0025135) were also predicted. Then 497 overlapped genes regulated by these six miRNAs above had been predicted, and function enrichment analysis revealed these genes are mainly linked with some regulation functions of cancers. Ten hub-genes (PTGER3, ADCY2, APLN, CXCL5, GRM4, MCHR1, NPY5R, CXCR4, ACKR3, MTNR1B) have been screened from a PPI network. PTGER3, ADCY2, CXCL5, GRM4 and APLN were identified to have a significant effect on the overall survival time of patients with ccRCC. Furthermore, one compound (josamycin) and four kinds of drugs (capecitabine, hmgcoa reductase inhibitors, ace Inhibitors and bevacizumab) were confirmed as potential therapeutic options for ccRcc by cMap analysis and pharmacogenomics analysis. this study implies the potential pathogenesis of the regulatory network among circRnA/miRnA/mRnA and provides some potential therapeutic options for ccRcc. Renal cancer is common cancer, and the incidence rates in males and females are 5% and 3%, respectively 1. Clear cell renal cell carcinoma (ccRCC) accounts for 70-80% of renal cancer, which is the most representative

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Section: Discussionmentioning

confidence: 99%

Construct a circRNA/miRNA/mRNA regulatory network to explore potential pathogenesis and therapy options of clear cell renal cell carcinoma

Bai

Yan

et al. 2020

Sci Rep

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“…Additionally, the physical and psychosocial domains of HRQoL were negatively associated with female gender, which is consistent with previously published research. 42 Female gender is associated with worse HRQoL despite controlling for potential confounding factors, such as sociodemographic variables (e.g., age, income, and education, among others). 42 Illness duration was negatively associated with the physical domain, consistent with previously published studies that found a negative association between the duration of chronic health conditions and HRQoL scores.…”

Section: Discussionmentioning

confidence: 99%

“…42 Female gender is associated with worse HRQoL despite controlling for potential confounding factors, such as sociodemographic variables (e.g., age, income, and education, among others). 42 Illness duration was negatively associated with the physical domain, consistent with previously published studies that found a negative association between the duration of chronic health conditions and HRQoL scores. 43 Chronic health conditions, such as diabetes and arthritis, result in loss of HRQoL as time progresses.…”

Section: Discussionmentioning

confidence: 99%

<p>The Relationship Between Health-Related Quality of Life and Trust in Primary Care Physicians Among Patients with Diabetes</p>

AlRuthia

Sales

Almalag

et al. 2020

CLEP

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Background: Trust is pivotal for a productive relationship between patients and healthcare providers and is positively correlated with multiple clinical and humanistic outcomes. However, the impact of trust in healthcare providers on different domains of health-related quality of life (HRQoL) among diabetic patients has not been studied in detail. Purpose: The aim of this study was to examine the association between the physical, mental or psychological, social, and environmental domains of HRQoL with the patients' trust in their primary care physicians while controlling for several sociodemographic and clinical factors. The study was conducted among a sample of diabetic patients. Patients and Methods: This study had a prospective questionnaire-based, multi-center, crosssectional design. The patients were recruited from three public hospitals in Saudi Arabia. Patients' experiences and trust in their primary care physicians were assessed using the Health Care Relationship Trust (HCR-Trust) scale. HRQoL was assessed using the Arabic version of the World Health Organization Quality of Life-BREF (WHOQOL-BREF). Multiple linear regression was conducted to assess the relationship between HCR-Trust and the WHOQOL-BREF physical, psychological, social, and environmental domains controlling for age, Charlson Comorbidity Index (CCI) score, health literacy, sex, education, annual income, nationality, and illness duration. Results: Three hundred and sixty-four patients participated in the study. The scores in all four domains of WHOQOL-BREF were positively associated with HCR-Trust scores of the diabetic patients. Additionally, the scores in the physical (β = −10.26; 95% CI: −13.77 to −6.74; P < 0.0001) and psychological (β = −3.91; 95% CI: −7.44 to −0.38; P < 0.0001) domains were negatively associated with female gender. Furthermore, the physical domain score was negatively associated with the duration of illness (β = −0.26; 95% CI: −0.506 to −0.02; P = 0.032). The environmental domain score was positively associated with annual income (β = 2.31; 95% CI: 1.05 to 3.56; P = 0.030). Other patient characteristics, such as age and education, were not associated with the scores of any of the WHOQOL-BREF domains. Conclusion: Patient trust in healthcare providers is positively associated with different domains of HRQoL. Therefore, building and maintaining trust with patients is important to achieve favorable treatment outcomes.

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“…It also provides important information for improving HPV vaccine uptake in other jurisdictions, including the US and Canada, where programs are not meeting their targets. 22,23…”

Section: Introductionmentioning

confidence: 99%

Knowledge and awareness of Human Papillomavirus (HPV) and HPV vaccines among Caribbean youth: the case of the Bahamas

George

Roberts

Brennen

et al. 2019

Human Vaccines & Immunotherapeutics

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There is a high burden of cervical cancer in the Caribbean region, particularly in the Bahamas, yet there are few studies of Human Papillomavirus (HPV) and HPV vaccine in the region. The objective of this study was to assess the knowledge and awareness of HPV and the HPV vaccine among school-aged youth (15-18 years) living in the Bahamas. Cross-sectional data were obtained from the "Getting to Zero" HIV study in the Bahamas conducted in 2014/2015 (n = 1553). The questionnaire elicited information on knowledge of HPV and HPV vaccines, using previously validated scales. Data analysis included Chi-square tests and Mann Whitney U test. In this sample of school-aged youth, only 10.7% (146/1364) had ever heard of HPV. With respect to those who were sexually active (n = 685), only 10.7% had ever heard of HPV. For those who had heard of HPV, knowledge of HPV and HPV vaccines was assessed on an HPV Knowledge and HPV Vaccine Knowledge scale, respectively. There was no statistically significant difference in mean HPV knowledge score between males and females, or HPV vaccine knowledge scores, between males and females. There was a general lack of awareness of HPV and HPV vaccines among school-aged youth in the Bahamas. This is an important gap in the HPV vaccine strategy and cancer prevention, as this is the age at which most people acquire HPV. It emphasizes the importance of developing a careful implementation plan, with an evaluation of knowledge and attitudes, in order to have an effective HPV vaccine uptake.

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Imminent angiotensin-converting enzyme inhibitor from microbial source for cancer therapy

Cited by 9 publications

References 35 publications

Construct a circRNA/miRNA/mRNA regulatory network to explore potential pathogenesis and therapy options of clear cell renal cell carcinoma

Construct a circRNA/miRNA/mRNA regulatory network to explore potential pathogenesis and therapy options of clear cell renal cell carcinoma

<p>The Relationship Between Health-Related Quality of Life and Trust in Primary Care Physicians Among Patients with Diabetes</p>

Knowledge and awareness of Human Papillomavirus (HPV) and HPV vaccines among Caribbean youth: the case of the Bahamas

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