Changes in the biochemical constituents and morphologic appearance of the human cervical stroma during pregnancy

Myers, Kristin M.; Socrate, Simona; Tzeranis, Dimitrios S.; House, Michael

doi:10.1016/j.ejogrb.2009.02.008

Cited by 124 publications

(114 citation statements)

References 31 publications

(68 reference statements)

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“…In both species, the glycosaminoglycan composition is altered over the course of pregnancy and likely modulates matrix organization (Maillot & Zimmermann 1976, Osmers et al 1993, Myers et al 2009, Akgul et al 2012. This includes increased concentration of HA in the stroma and mucus that ranges from high to low molecular weight and increased transcription of hyaluronidase 2 (Akgul et al 2012).…”

Section: Relevance To Cervical Remodeling In Womenmentioning

confidence: 99%

Cervical remodeling in term and preterm birth: insights from an animal model

Mahendroo¹

2012

Reproduction

170

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Proper cervical function is essential for a normal pregnancy and birth to occur. Understanding the mechanisms that take place in normal pregnancy will allow a better comprehension of the complications involved in premature cervical remodeling and lead to better methods of diagnostics and prevention for preterm birth. Unfortunately, human samples are not easily available, and samples that are collected are often confounded by variations in timing and region of cervix from which sample is collected. Animal models, specifically the mouse, have facilitated a great deal of exploration into the mechanisms of cervical function and pathways of preterm birth. This review highlights some of the groundbreaking discoveries that have arisen from murine research including 1) the identification of early pregnancy changes in collagen fibril processing and assembly that result in progressive modifications to collagen architecture with subsequent loss of tissue stiffness during pregnancy, 2) the determination that immune cells are not key to cervical ripening at term but have diverse phenotypes and functions in postpartum repair, and 3) the finding that the process of preterm cervical ripening can differ from term ripening and is dependent on the etiology of prematurity. These findings, which are relevant to human cervical biology, provide new insights that will allow targeted studies on the human cervix as well as identify potential biomarkers for early detection of premature cervical ripening and development of improved therapies to prevent premature ripening of the cervix and subsequent preterm birth.

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Section: Relevance To Cervical Remodeling In Womenmentioning

confidence: 99%

Cervical remodeling in term and preterm birth: insights from an animal model

Mahendroo¹

2012

Reproduction

170

146

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“…In samples obtained from parous patients, the thermal transition of collagen was lower in comparison with the samples from nulliparous patients. This finding requires future study and might be correlated with changes in collagen tissue after pregnancy reported by other authors, but not in peritoneal tissue [49][50][51][52][53][54][55][56][57][58][59][60][61].…”

Section: Discussionmentioning

confidence: 84%

“…Therefore, we decided to extend our analysis to other parameters that might suggest changes in the status of collagen within the peritoneum. The structure of connective tissue in pregnancy might be altered [49][50][51]. Collagen fiber disruption and a decrease in collagen cross-linking may be associated with softening of the uterine cervix [52][53][54].…”

Section: Discussionmentioning

confidence: 99%

Stability of peritoneal tissue evaluated by the means of DSC in obese patients undergoing laparoscopic cholecystectomy

Torres

Trębacz

Pietrzyk

et al. 2017

J Therm Anal Calorim

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Obesity is considered to be the leading metabolic disease in the world. The coincidence of postoperative complications is higher in obese individuals; thus, laparoscopic techniques due to their minimally invasive character became a standard in the surgical treatment of obesity. The proper function of peritoneal tissue is essential for the response to surgical trauma. Therefore, understanding the alterations of peritoneal tissue of obese individuals might explain the increased number of postoperative complications observed in obese patients. The study aimed to assess whether the stability of peritoneum is altered in obese patients and whether it corresponds to early postoperative complications in obese patients. Samples of parietal peritoneal tissue were collected at the beginning of the laparoscopic cholecystectomy from 80 patients. Differential scanning calorimetry was performed on samples defrosted at room temperature. Patients were divided into three groups according to the BMI value. For statistical analysis, ANOVA, Chi-square, Student's t test, and correlations with Pearson test were used. Significantly lower DH and higher T m were in patients in whom intraperitoneal adhesions were reported. Lower DH was reported in samples obtained from patients with temperature above 37°C in the first 24 h postoperatively. Enthalpy of thermal transition (DH) in peritoneum obtained from parous was significantly lower in comparison with the samples from nullipara. It can be concluded that DSC parameters correlated with parameters related to the early postoperative period. Occurrence of adhesions was reported more frequently in the group of obese and overweight individuals and correlated with lower change in enthalpy of collagen denaturation.

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“…This can result in interand intra-subject variability of SWS estimates. Given that tissue strength depends upon the degree of collagen crosslinking, [30,31] this complicated structure is expected to disrupt close to term to allow the cervix to soften. Thus, we hypothesize that the reduction in variance close to term could be explained by disruption of collagen crosslinks and the consequent structural homogenization.…”

Section: Discussionmentioning

confidence: 99%

Changes in cervical stiffness during pregnancy: Preliminary assessment with shear wave elasticity imaging in the rhesus macaque

Rosado‐Mendez

Guerrero

Drehfal

et al. 2016

AIP Conference Proceedings

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Changes in the biochemical constituents and morphologic appearance of the human cervical stroma during pregnancy

Abstract: Significant changes were seen in the concentration and organization of cervical ECM constituents during normal pregnancy.

Cited by 124 publications

References 31 publications

Cervical remodeling in term and preterm birth: insights from an animal model

Cervical remodeling in term and preterm birth: insights from an animal model

Stability of peritoneal tissue evaluated by the means of DSC in obese patients undergoing laparoscopic cholecystectomy

Changes in cervical stiffness during pregnancy: Preliminary assessment with shear wave elasticity imaging in the rhesus macaque

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