Changes in Stromal and Luminal Areas of the Choroid in Pachychoroid Diseases: Insights Into the Pathophysiology of Pachychoroid Diseases

Lee, Minsub; Lee, Hyungwoo; Kim, Hyung Chan; Chung, Hyewon

doi:10.1167/iovs.18-25018

Cited by 39 publications

(40 citation statements)

References 41 publications

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“…This important finding could be of interest for the interpretation of pathological features. 57 The choroidal VI has been suggested to be a potential marker of pathology in uveitis, where it has been shown to be increased in the acute stages of MEWDS disease, 58 and in CSC, where it has been suggested to be decreased in the chronic neovascularized forms of the disease. 59 …”

Section: Discussionmentioning

confidence: 99%

Topographic Variations of Choroidal Thickness in Healthy Eyes on Swept-Source Optical Coherence Tomography

Touhami

Philippakis

Mrejen

et al. 2020

Invest. Ophthalmol. Vis. Sci.

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To assess topographic variations of choroidal thickness (CT) in the fovea and beyond in healthy eyes. METHODS. This cross-sectional study included healthy subjects ≤ 55 years of age with axial lengths (22-26 mm) and refractive error margins (-4D, +4D) in normal ranges. Images were acquired using swept-source optical coherence tomography angiography (OCT-A). Corneal thickness (CT) maps from 12 × 12-mm radial scans and 9 × 9-mm OCT-A B-scans were analyzed. RESULTS. The study included 64 eyes of 33 subjects (mean age, 37 years). Mean CT was >300 μm in all locations except the nasal outer macula. The subfoveal CT was >395 μm in 30% of cases; in 38.7% of cases, >50% of the CT map was thicker than 395 μm. The mean thickest choroidal point was 395.2 μm (range, 164-548 μm), located superior and temporal to the macula in 72.2% of cases and subfoveally in 1.8% of cases. The CT pattern was symmetrical (58%) or asymmetrical (42%) along a horizontal axis correlating with choroidal vein distribution. Half of the asymmetrical patterns were thicker in the inferior quadrants, with an oblique temporal watershed of venous drainage, and the other half were thicker superiorly. The mean vascularity index was ∼75% regardless of the mean CT. CONCLUSIONS. One-third of healthy eyes of patients younger than age 55 had a thick choroid (>395 μm). In these normal eyes, the thickest choroidal point was not subfoveal, CT symmetry above and below the fovea depended on choroidal vein distribution, and choroidal vascularity index was independent from CT. No patients demonstrated fundus autofluorescence abnormalities, and the choriocapillaris remained visible even in thick choroids. These features could be interesting when differentiating normal versus pathological states.

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Section: Discussionmentioning

confidence: 99%

Topographic Variations of Choroidal Thickness in Healthy Eyes on Swept-Source Optical Coherence Tomography

Touhami

Philippakis

Mrejen

et al. 2020

Invest. Ophthalmol. Vis. Sci.

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“…The remaining area is dubbed the 'stromal' area, accounting for nonvascular tissue. In comparison to controls, patients with cCSC were found to have a higher CVI and a reduced stromal area to choroidal area ratio (Lee et al 2018). The authors postulate that the reduced stromal: choroidal area ratio is indicative of stromal atrophy resulting from a low-grade inflammation.…”

Section: Choroidal Dysfunctionmentioning

confidence: 96%

Central serous chorioretinopathy: An update on risk factors, pathophysiology and imaging modalities

Kaye

Chandra

Sheth

et al. 2020

Progress in Retinal and Eye Research

158

216

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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“…CVI and lumen/choroid ratio have been described as ratios to assess the luminal area versus total choroidal area [22][23][24][25].…”

Section: Introductionmentioning

confidence: 99%

Prospective evaluation of changes in choroidal vascularity index after half-dose photodynamic therapy versus micropulse laser treatment in chronic central serous chorioretinopathy

Rijssen

Singh

Dijk

et al. 2020

Graefes Arch Clin Exp Ophthalmol

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Purpose To assess whether treatment of chronic central serous chorioretinopathy (cCSC) with photodynamic therapy (PDT) and high-density subthreshold micropulse laser (HSML) results in choroidal vascularity index (CVI) changes that may account for the treatment effect. Methods Patients with cCSC were prospectively included and analyzed. Patients received either half-dose PDT or HSML treatment. CVI of the affected and unaffected eye was obtained before treatment, 6 to 8 weeks after treatment, and 7 to 8 months after treatment. Results At baseline, 29 eyes (29 patients) were included both in the PDT and in the HSML group. The mean (± standard deviation) CVI change in the HSML group between before PDT and 6 to 8 weeks after PDT was − 0.009 ± 0.032 (p = 0.127), whereas this was 0.0025 ± 0.037 (p = 0.723) between the visit before PDT and final visit. The patients in the PDT group had a CVI change of − 0.0025 ± 0.037 (p = 0.723) between the visit before PDT and first visit after PDT, and a mean CVI change of − 0.013 ± 0.038 (p = 0.080) between the visit before PDT and final visit. There was no significant correlation between CVI and BCVA at the measured time points, in both the HSML group (p = 0.885), and in the PDT group (p = 0.904). Moreover, no significant changes in CVI occurred in the unaffected eye at any time point. Conclusions PDT and HSML do not significantly affect CVI, and therefore a CVI change may not be primarily responsible for the treatment effect. The positive treatment effect of both interventions may rely on other mechanisms, such as an effect on choriocapillaris and/or retinal pigment epithelium function.

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Changes in Stromal and Luminal Areas of the Choroid in Pachychoroid Diseases: Insights Into the Pathophysiology of Pachychoroid Diseases

Cited by 39 publications

References 41 publications

Topographic Variations of Choroidal Thickness in Healthy Eyes on Swept-Source Optical Coherence Tomography

Topographic Variations of Choroidal Thickness in Healthy Eyes on Swept-Source Optical Coherence Tomography

Central serous chorioretinopathy: An update on risk factors, pathophysiology and imaging modalities

Prospective evaluation of changes in choroidal vascularity index after half-dose photodynamic therapy versus micropulse laser treatment in chronic central serous chorioretinopathy

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