Changes in starch structure during manufacturing of starch microspheres for use in parenteral drug formulations: Effects of temperature treatment

Elfstrand, Lidia; Eliasson, Ann‐Charlotte; Wahlgren, Marie

doi:10.1016/j.carbpol.2008.07.018

Cited by 14 publications

(5 citation statements)

References 28 publications

(34 reference statements)

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“…Furthermore, the values of Δ H obtained for the dry microspheres were generally lower than for their wet counterparts. This demonstrated the destructive effect of freeze‐drying on the crystalline structure, as previously discussed by Elfstrand et al25…”

Section: Resultssupporting

confidence: 78%

The Effect of Starch Material, Encapsulated Protein and Production Conditions on the Protein Release from Starch Microspheres

Elfstrand

Eliasson

Wahlgren

2009

Journal of Pharmaceutical Sciences

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Section: Resultssupporting

confidence: 78%

The Effect of Starch Material, Encapsulated Protein and Production Conditions on the Protein Release from Starch Microspheres

Elfstrand

Eliasson

Wahlgren

2009

Journal of Pharmaceutical Sciences

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“…The SF/chitosan blended microparticles have been prepared by the coacervation/cross-linking method [14]. Starch is a non-toxic, biodegradable, biocompatible, edible and relative inexpensive material that has been widely studied in the entrapment of food ingredients [15,16] and drugs [17][18][19]. Almost all starch microparticles have been prepared by an emulsification-cross-linking reaction [17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Morphology and thermal stability of silk fibroin/starch blended microparticles

Baimark¹,

Srisa-ard²,

Srihanam³

2010

Express Polym. Lett.

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Abstract. In the present study biodegradable microparticles of silk fibroin (SF)/starch blends were prepared by a simple water-in-oil emulsion solvent diffusion technique. SF/starch blended solution and ethyl acetate were used as water and oil phases, respectively. The influence of SF/starch ratios on characteristics of the blended microparticles was investigated. The SF conformation of microparticle matrices from FTIR analysis was changed from random coil to β-sheet form by blending with starch. The blended microparticles had lower dissolution in water than those of SF and starch microparticles. The 1/3 (w/w) SF/starch blended microparticles exhibited the lowest dissolution. The SF and starch microparticles showed irregular and deflated shapes, respectively. The blended microparticles were nearly spherical in shapes and smaller sizes. Thermal stability of the blended microparticles slightly increased with the starch blended ratio. The results suggested that SF conformational transition, thermal stability, morphology and dissolution of the blended microparticles can be adjusted by varying the blended ratio.

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“…Starch microspheres (SMs) are micron-sized spherical particles consisting of starch chains/starch derivatives which have been widely used as drug delivery systems, embolizing agents and hemostatic agents (Chen et al, 2017;Orlacchio et al, 2020;Puncha-Arnon et al, 2020;Ee et al, 2020). SMs can be prepared by precipitation, solvent evaporation, spray-drying and emulsion techniques (Elfstrand et al, 2009;Li et al, 2009;Ma et al, 2011). The emulsion technique is one of the classic methods to obtain starch-based microparticles (Li et al, 2009;Seki et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Quinoa starch microspheres for drug delivery: preparation and their characteristics

LUO

Fu-tai

GUO³

et al. 2022

Food Sci. Technol

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Quinoa starch microparticles (QSMs) fabricated with unhydrolyzed quinoa starch (QS) by inverse microemulsion technology could be used as medicine delivery and cosmetic accessories. The size distribution of QSMs was uniform at 28.5 μM, and the adsorption capacity of methylene blue was 0.82 mg/ g. The optimum preparation process was as follows: a QS mass fraction of 9%, an epoxy chloropropane content of 1%, an amount of oil phase of 100 mL, a span 80 of 3 mg/mL, and a stirring speed of 400 r/min for 3 h at room temperature and pressure. The QSMs were spherical, ellipsoidal in shape with the specific surface area of 1.676 m 2 /g. The crystallinity of the QSMs increased from 1.24% to 16.8% after crosslinking. The maximum thermal degradation temperature of the QSMs rose slightly than QS. It will be a promising material for application as a drug carrier and in cosmetics.

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Changes in starch structure during manufacturing of starch microspheres for use in parenteral drug formulations: Effects of temperature treatment

Cited by 14 publications

References 28 publications

The Effect of Starch Material, Encapsulated Protein and Production Conditions on the Protein Release from Starch Microspheres

The Effect of Starch Material, Encapsulated Protein and Production Conditions on the Protein Release from Starch Microspheres

Morphology and thermal stability of silk fibroin/starch blended microparticles

Quinoa starch microspheres for drug delivery: preparation and their characteristics

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