Changes in staphylococcal cassette chromosome type and antibiotic resistance profile in methicillin-resistant Staphylococcus aureus isolates from a French hospital over an 11 year period

Abstract

During the course of the study, the spectrum of antibiotic resistance in MRSA isolates decreased. This occurred due to the emergence of strains with SCC type IV or IVA, which are susceptible to more antibiotics than type I or IA strains. The greater prevalence of such isolates could not be linked conclusively to the presence of SCC type IV or IVA, or to one particular PFGE cluster.

Methicillin Resistant Staphylococcus aureus (MRSA): A Review

“…Transboundary transmission of MRSA strain is reported between countries like North America and Middle East, Asia and South America (Stefani et al, 2012). The spread of CA-MRSA has extended to healthcare centres in USA and France (Donnio et al, 2004). Outbreaks of CA-MRSA is mostly seen from populations such as sports teams (Collins and Oꞌcon-nell, 2012), prisons (Palavecino, 2004), day care centers (Simmonds et al, 2008), military quarters (Marchese et al, 2000) homeless people (Yano et al, 2000), and intravenous drug users (Torres-Tortosa et al, 1994).…”

Emergence of SCCmec Type IV as the Most Common Type of Methicillin-Resistant Staphylococcus aureus in a University Hospital

“…Up to six main types of SCCmec and many variants, especially of type IV are known [1,5,6]. Type IV is present in many more genetic backgrounds than other types suggesting an enhanced mobility [7][8][9]. In contrast to HA-MRSA, community-associated MRSA (CA-MRSA) strains are commonly susceptible to the majority of non-b-lactam antibiotics, frequently expressing genes encoding for PVL and are predominantly of the SCCmec types IV and V, and present multiple patterns by pulsedfield gel electrophoresis [10,11].…”

Increasing Incidence of Sterile-Site Infections Due to Non-Multidrug-Resistant, Oxacillin-Resistant Staphylococcus aureus Among Hospitalized Patients

“…However, trials increase in ssis due to oxacillin-resistant s. aureus 97 that have performed molecular typing of non-multidrug resistant, oxacillin-resistant S. aureus isolates have found the strains to be predominately SCCmec type IV. 7,[11][12][13][14] Consequently, an antimicrobial profile with susceptibility to multiple non-b-lactam antibiotics could be used as a phenotypic marker for community-type strains and the possibility that the organism produces potentially lethal toxins. 2,3,15 Despite these limitations of our study, the larger point is to reinforce the evidence that incidence of CA-MRSA SSIs that require hospitalization is increasing, as well as to recognize that there are HC-MRSA isolates that are susceptible to multiple non-b-lactam antibiotics.…”