Changes in spinal cord met-enkephalin levels and mechanical threshold values of pain after pulsed radio frequency in a spared nerve injury rat model

Wu, Baishan; Ni, Jiaxiang; Zhang, Chunlei; Fu, Paul; Yue, Jianning; Yang, Liqiang

doi:10.1179/1743132812y.0000000026

Cited by 15 publications

(16 citation statements)

References 37 publications

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“…Main features of in vivo studies are shown in Table , divided by the type of stimulation in PRF stimulation group and EFS group . In all in vivo studies, SD rats weighing from 149 to 350 g were used.…”

Section: Resultsmentioning

confidence: 99%

“…Only one of these studies used female rats . Within the PRF group, four out of six studies used SNL model to induce neuropathic pain , one study used spared nerve injury (SNI) model and one used chronic constriction injury (CCI) model . In the EFS group one study used tibial nerve injury (TNI) model to induce neuropathic pain and one used acute noxious stimulation of hind paw .…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Electrical Stimulation of Dorsal Root Ganglion in the Context of Pain: A Systematic Review of In Vitro and In Vivo Animal Model Studies

Vuka

Vučić

Repić

et al. 2018

Neuromodulation: Technology at the Neural Interface

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Electrical Stimulation of Dorsal Root Ganglion in the Context of Pain: A Systematic Review of In Vitro and In Vivo Animal Model Studies

Vuka

Vučić

Repić

et al. 2018

Neuromodulation: Technology at the Neural Interface

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“…13 Preclinical studies also suggest that enhancement of descending noradrenergic, serotonergic, and opioid inhibitory pathways, alterations in gene expression, and temporary suppression of excitatory neurotransmission may play a role in antinociception. 13,25,38,54,59 Numerous preclinical 3,44,53 and several placebo-controlled studies 34,41,57 have demonstrated the efficacy of PRF for neuropathic pain. For ON, several uncontrolled studies have reported benefit, 12,31,51,55,56 with one study suggesting that pulsed RF might provide longer term benefit than steroid injections.…”

Section: Introductionmentioning

confidence: 99%

Randomized, double-blind, comparative-effectiveness study comparing pulsed radiofrequency to steroid injections for occipital neuralgia or migraine with occipital nerve tenderness

Cohen

Peterlin

Fulton

et al. 2015

Pain

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Occipital neuralgia (ON) is characterized by lancinating pain and tenderness overlying the occipital nerves. Both steroid injections and pulsed radiofrequency (PRF) are used to treat ON, but few clinical trials have evaluated efficacy, and no study has compared treatments. We performed a multicenter, randomized, double-blind, comparative-effectiveness study in 81 participants with ON or migraine with occipital nerve tenderness whose aim was to determine which treatment is superior. Forty-two participants were randomized to receive local anesthetic and saline, and three 120 second cycles of PRF per targeted nerve, and 39 were randomized to receive local anesthetic mixed with deposteroid and 3 rounds of sham PRF. Patients, treating physicians, and evaluators were blinded to interventions. The PRF group experienced a greater reduction in the primary outcome measure, average occipital pain at 6 weeks (mean change from baseline −2.743 ± 2.487 vs −1.377 ± 1.970; P <0.001), than the steroid group, which persisted through the 6-month follow-up. Comparable benefits favoring PRF were obtained for worst occipital pain through 3 months (mean change from baseline−1.925 ± 3.204 vs−0.541 ± 2.644; P = 0.043), and average overall headache pain through 6 weeks (mean change from baseline −2.738 ± 2.753 vs −1.120 ± 2.1; P = 0.037). Adverse events were similar between groups, and few significant differences were noted for nonpain outcomes. We conclude that although PRF can provide greater pain relief for ON and migraine with occipital nerve tenderness than steroid injections, the superior analgesia may not be accompanied by comparable improvement on other outcome measures.

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“…Various experimental neuropathic pain models show the pain-relieving effect of PRF on mechanical hypersensitivity, and sometimes on thermal allodynia [79][80][81][82][83][84] (Table 1). …”

Section: Behavioral Studiesmentioning

confidence: 99%

“…82,84 Additionally, the level of Met-enkephalin in the dorsal horn was significantly increased in the spinal cord in the first 24 hours after PRF application, suggesting a possible role for endogenous opioids. 83 Pulsed radiofrequency effects on thermal allodynia have been shown to be attenuated through not only the intrathecal administration of an α2-adrenoceptor antagonist, but also application of a selective 5-HT3 serotonin receptor antagonist and a nonselective serotonin receptor antagonist. These observations suggest that the analgesic effect of PRF may involve descending noradrenergic and serotonergic inhibitory pathways.…”

Section: Behavioral Studiesmentioning

confidence: 99%

Pulsed Radiofrequency

Boxem

Huntoon

Zundert

et al. 2014

Regional Anesthesia and Pain Medicine

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Radicular pain is an important health care problem, with only limited evidence-based treatments available. Treatment selection should ideally target documented pathophysiological pathways. In herniated discs, a sequence in the inflammatory cascade can be observed that initiates and maintains increased nociceptive signal input. Inflammatory mediators including tumor necrosis factor α are released from the nucleus pulposus and the degenerating peripheral nerve, which, in turn, induces production of neurotrophins like nerve growth factor and brain-derived neurotrophic factor. Neurotrophins interfere not only with the generation of ectopic firing of nociceptive neurons in the dorsal root ganglion but also with the excitability and sensitization of neuronal transmission in the dorsal spinal horn. Radicular pain is further characterized by the electrophysiological spreading of the afferent nociceptive input over different spinal nerve roots. Both the complex pathophysiological pathways involved and the spreading of the nociceptive signal make radicular pain difficult to treat. Pulsed radiofrequency (PRF) is considered an option in treatment of radicular pain. To understand and increase the efficiency of PRF interventional treatments in radicular pain, both in vitro and in vivo studies aiming at elucidating part of the mechanism of action of PRF are described. Potential factors that may improve the efficacy of PRF treatment in radicular pain are discussed.

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Changes in spinal cord met-enkephalin levels and mechanical threshold values of pain after pulsed radio frequency in a spared nerve injury rat model

Cited by 15 publications

References 37 publications

Electrical Stimulation of Dorsal Root Ganglion in the Context of Pain: A Systematic Review of In Vitro and In Vivo Animal Model Studies

Electrical Stimulation of Dorsal Root Ganglion in the Context of Pain: A Systematic Review of In Vitro and In Vivo Animal Model Studies

Randomized, double-blind, comparative-effectiveness study comparing pulsed radiofrequency to steroid injections for occipital neuralgia or migraine with occipital nerve tenderness

Pulsed Radiofrequency

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