Changes in serum inflammatory factors in acute gouty arthritis patients treated using ultrashort wave combined with loxoprofen sodium

Abstract

Objectives: To study the effect of ultrashort wave combined with loxoprofen sodium on serum inflammatory factors in patients with acute gouty arthritis.
 Methods: Records of patients with acute gouty arthritis who were treated in The Fourth Hospital of Changsha from May 2018 to September 2020, were reviewed. Of them, 77 cases were selected and divided into two groups based on the received treatment. The control group (n=39) was treated with loxoprofen sodium, and the treatment group (n=38) was treated with an ultrashort wave combined with loxoprofen sodium, for 10 continuous days. The clinical efficacy of the treatment in two groups was analyzed.
 Results: After treatment, the quality of life of patients in both groups was improved (P < 0.05), but there was no significant difference in the degree of improvement between the two groups (P > 0.05). After treatment, the VAS score of the treatment group was lower than that of the control group (P < 0.05), the improvement of symptoms and signs of the treatment group was better than that of the control group (P < 0.05). Serum CRP and ESR levels in the treatment group were lower than those in the control group (P < 0.05), and the serum IL-1 β, IL-8, TNF-a and MMP-3 levels of the treatment group were lower than those of the control group (P < 0.05). The total effective rate of the treatment group (94.87%) was slightly higher than that of the control group (89.47%), but the difference was not statistically significant (P>0.05). No adverse reactions occurred in all patients during the treatment.
 Conclusion: An ultrashort wave combined with loxoprofen sodium in the treatment of acute gouty arthritis can reduce the inflammatory reaction, improve the degree of joint pain and swelling, improve the curative effect, and do not increase the adverse reactions. The results may be related to the regulation of IL-1 β, IL-8, TNF-a and MMP-3.
 doi: https://doi.org/10.12669/pjms.37.7.4765
 How to cite this:Wu Y, Wang Y, Yuan W, Xiao X, Cheng G. Changes in serum inflammatory factors in acute gouty arthritis patients treated using ultrashort wave combined with loxoprofen sodium. Pak J Med Sci. 2021;37(7):---------. doi: https://doi.org/10.12669/pjms.37.7.4765
 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

LncRNA HOTTIP promotes inflammatory response in acute gouty arthritis via miR‐101‐3p/BRD4 axis

“…According to statistics, about 3.9% of people worldwide suffer from gout, of which the annual incidence of AGA is 1.1% 2 . The prevalence of hyperuricemia in mainland China is 13.3%, and the prevalence of gout is as high as 6% 3 . AGA is characterized by rapid onset, severe disease, and poor prognosis, so treatment focuses on rapid control of the acute inflammatory response and reduction of joint pain 2 .…”

“…lncRNA HOXA distal transcript antisense RNA (HOTTIP) is located on chromosome 7p15.2. It has been reported to be associated with inflammatory responses, oral submucosal fibrosis, 3 diabetic nephropathy, 8 and ovarian cancer 9 . HOTTIP inhibits cartilage differentiation, leads to cartilage degradation, and promotes the development of osteoarthritis 10 .…”