Changes in serum ceruloplasmin levels with commonly used methods of contraception

Sontakke, Alka N.; More, Umesh

doi:10.1007/bf02872401

Cited by 8 publications

(8 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In contract to female subgroup, male patients group failed to exhibit a significant differences between patients and healthy males in the levels of serum ceruloplasmin oxidase activity, where ceruloplasmin oxidase activity results of obese male were interfered with the results of healthy men subgroup (Figures 7 (B)). With the same opinions, the levels of serum ceruloplasmin oxidase concentrations of the obese men were asymptotical to the levels of the same parameter in serum of control men subgroup, as demonstrated in Figures 8 (B).The current work findings came compatible with the scientific facts that indicated estrogens mainly responsible for the increased level of serum ceruloplasmin, when they act as an inducer for synthesis of ceruloplasmin RNA templates causing subsequent increase in synthesis of the protein; while progesterone causes a less drastic rise (56) .…”

Section: Fig6 Correlation Of Bmi and Serum Cp Concentration In (A):psupporting

confidence: 89%

Assessment of Concurrent Cellular Oxidative Stress with the Body Weight Gain in Serum of Obese Patients Undergoing to Surgical / Non-Surgical Strategies for Reducing an Excess Weight

Lefta¹,

Jasim²

2016

International Journal of Advanced Research in Chemical Science

View full text Add to dashboard Cite

Obesity is not a single disease, there are 300 different genes were linked to obesity, in addition to several environmental factors could be associate to obesity happening, while most considerations common indicted to the fact that obesity process is a result of an interaction of environmental factors with the genetic predisposition lead to fat accumulation and increased in the adipose tissues. Under normal conditions ROS and RNS are produced. This production balanced by number of acceptor electron molecules that synthesized cellular. An injured tissues caused by disorders in the balance between the production of reactive species of known as free radicals and antioxidants which is the defensive mechanism, through this status the raise in the oxidation processes will occur in contrast to the reduction in the synthesis of defense molecules. Subjects: 47patients (33.28 ±7.424 years with age range 34 years) and 24 healthy individuals (25.96 ± 3.983 years with age range 13 years) were enrolled in the present study. Patients with BMI more than 30 Kg/m 2 (45.179 ± 9.09 Kg/m 2 , and 38.7 Kg/m 2 as BMI range); haven't diabetes mellitus, they aren't subjected to obesity surgical operation before. Control group might at approximate age range with the patients group, with similar food style. Average BMI of no smoking, no alcohol drinking healthy group was 18.5 Kg/m 2 (22.829 ± 0.752 Kg/m 2). Results: Evaluation of the MDA concentrations revealed a significant increase (p < 0.05) in patients of obesity when compared with healthy individuals. From the statistical analysis of the obese patients group, a positive correlation between the serum MDA concentration with BMI raise (r = 86.925 % at p < 0.001). while highly significant differences (p < 0.05) were noticed at the two study's groups were compared together, when both of ceruloplasmin oxidase activity and concentration were examined. It has been monitoring the positive relations between BMI levels and both of the activity and concentration of ceruloplasmin oxidase enzyme in the sera samples of obese patients group, where the activity and concentration of ceruloplasmin oxidase rose in 76.112 % and 68.869 % (at p < 0.05) of the total cases of patients. The Person's correlation demonstrated significant positive relationship in those of obese patients (r = 0.828 at p < 0.005), But not in those of controls group. Conclusion: MDA levels is affected during the overweight gain; and they correlated directly to BMI. Cp acts as acute phase protein in response to weight gain, in addition to its an antioxidant role to accommodate the overflow of electrons (free radicals) formed during the process of obesity.

show abstract

Section: Fig6 Correlation Of Bmi and Serum Cp Concentration In (A):psupporting

confidence: 89%

Assessment of Concurrent Cellular Oxidative Stress with the Body Weight Gain in Serum of Obese Patients Undergoing to Surgical / Non-Surgical Strategies for Reducing an Excess Weight

Lefta¹,

Jasim²

2016

International Journal of Advanced Research in Chemical Science

View full text Add to dashboard Cite

show abstract

“…3.059 , t crit 2.064, probability for a two-tail test was 0.005 ). Data reported by Lyngbye and Kroll [19] for a normal population (280 patients, 149 males and 111 females) also indicate significantly higher concentrations of Cp in female patients which are known to be caused by use of oral contraceptives [20].…”

Section: Ceruloplasmin Levels In Sera Frommentioning

confidence: 79%

Ceruloplasmin levels in human sera from various diseases and their correlation with patient’s age and gender

Lopez-Avila¹,

Robinson²,

Lokits³

2009

Health

View full text Add to dashboard Cite

Ceruloplasmin (Cp), a copper metalloprotein in human serum has been a valuable diagnostic marker in Wilson's disease where Cp levels tend to be low while high levels in serum were associated with myocardial infarction, neoplastic and inflammatory conditions. There is no standardized reference method for Cp and current immunologic and bichromatic assays have a number of drawbacks. The method described here uses immunoaffinity chromatography to remove six of the most abundant proteins from a serum sample and high-pressure liquid chromatography (HPLC) with a size-exclusion column to separate Cp from other serum proteins and any free Cu prior to analysis of 63 Cu and 65 Cu by inductively-coupled plasma mass spectrometry (ICPMS). Identification of Cp is based on retention time match of the unknown protein in the serum sample with the Cp external standard and the presence of 63 Cu and 65 Cu at a ratio of 2.2 ± 0.1. The method accuracy, as established independently by two of the authors with a reference serum certified for Cp, is 98 to 101% and the coefficient of variation is 6.4% and 5.4%, respectively. The assay was used to analyze a total of 167 human sera for Cp from patients with myocardial infarction (MI), pulmonary embolism (PE), rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), other forms of arthritis, and a set of healthy patients as normal controls (NC). Our data show that Cp concentrations tend to be higher in MI, RA, and SLE patients, higher in female as compared to male patients, and we did not observe a correlation between Cp concentration and patient's age for the set of 70 patients for which we had gender and age information.

show abstract

“… Patients on drugs like anticonvulsants[ 7 ] (carbamazepine, phenobarbital, phenytoin, valproic acid), oral contraceptive pills[ 8 ] Pregnant women Patients with previously diagnosed Wilson's disease. …”

Section: Methodsmentioning

confidence: 99%

“…Patients on drugs like anticonvulsants[ 7 ] (carbamazepine, phenobarbital, phenytoin, valproic acid), oral contraceptive pills[ 8 ]…”

Section: Methodsmentioning

confidence: 99%

Use of pleural fluid ceruloplasmin in the differentiation of exudative and transudative pleural effusion

Shanthaveeranna

Thykadavil

2015

Lung India

View full text Add to dashboard Cite

Background:Differentiating into transudate or exudate is the first step in the evaluation of effusions. Light's criteria is the standard but a significant number of transudates may not be differentiated based on these criteria. Acute phase proteins (APP) are present in plasma, which increase or decrease by about 25% during an acute inflammatory response. Ceruloplasmin (CP) is a positive APP. Hence, this study was done to know the diagnostic value of pleural fluid (pf) CP and pf to serum ceruloplasmin ratio (CPr) to differentiate the pleural effusion (PE) into exudate and transudate as compared to Light's criteria.Materials and Methods:Setting: Medical wards of St John's Medical College Hospital, Bangalore.Design:Cross-sectional descriptive study. Patients with PE were divided into exudate and transudate by definitive diagnosis. pfCP, CPr and Light's criteria were compared with definitive diagnosis for the differentiation of pf into exudate and transudate.Results:The mean value of the pfCP and CPr was found to be significantly different between exudates and transudates. Sensitivity and specificity of pfCP at ≥ 13.34 mg/dl is 89.7% and 83.3%, CPr at ≥ 0.37 is 91.4% and 83.3%, Light's criteria 94.82% and 83.3%, respectively. Light's criteria, pfCP and CPr have similar PPV (98%) with Light's criteria having higher NPV (62.5%) than pfCP (45%) and CPr (50%), respectively. CPr has higher NPV than pfCP.Conclusions:pfCP and CPr can differentiate pf into exudate and transudate with comparable PPV to Light's criteria.

show abstract

Changes in serum ceruloplasmin levels with commonly used methods of contraception

Cited by 8 publications

References 10 publications

Assessment of Concurrent Cellular Oxidative Stress with the Body Weight Gain in Serum of Obese Patients Undergoing to Surgical / Non-Surgical Strategies for Reducing an Excess Weight

Assessment of Concurrent Cellular Oxidative Stress with the Body Weight Gain in Serum of Obese Patients Undergoing to Surgical / Non-Surgical Strategies for Reducing an Excess Weight

Ceruloplasmin levels in human sera from various diseases and their correlation with patient’s age and gender

Use of pleural fluid ceruloplasmin in the differentiation of exudative and transudative pleural effusion

Contact Info

Product

Resources

About