Obesity is not a single disease, there are 300 different genes were linked to obesity, in addition to several environmental factors could be associate to obesity happening, while most considerations common indicted to the fact that obesity process is a result of an interaction of environmental factors with the genetic predisposition lead to fat accumulation and increased in the adipose tissues. Under normal conditions ROS and RNS are produced. This production balanced by number of acceptor electron molecules that synthesized cellular. An injured tissues caused by disorders in the balance between the production of reactive species of known as free radicals and antioxidants which is the defensive mechanism, through this status the raise in the oxidation processes will occur in contrast to the reduction in the synthesis of defense molecules. Subjects: 47patients (33.28 ±7.424 years with age range 34 years) and 24 healthy individuals (25.96 ± 3.983 years with age range 13 years) were enrolled in the present study. Patients with BMI more than 30 Kg/m 2 (45.179 ± 9.09 Kg/m 2 , and 38.7 Kg/m 2 as BMI range); haven't diabetes mellitus, they aren't subjected to obesity surgical operation before. Control group might at approximate age range with the patients group, with similar food style. Average BMI of no smoking, no alcohol drinking healthy group was 18.5 Kg/m 2 (22.829 ± 0.752 Kg/m 2). Results: Evaluation of the MDA concentrations revealed a significant increase (p < 0.05) in patients of obesity when compared with healthy individuals. From the statistical analysis of the obese patients group, a positive correlation between the serum MDA concentration with BMI raise (r = 86.925 % at p < 0.001). while highly significant differences (p < 0.05) were noticed at the two study's groups were compared together, when both of ceruloplasmin oxidase activity and concentration were examined. It has been monitoring the positive relations between BMI levels and both of the activity and concentration of ceruloplasmin oxidase enzyme in the sera samples of obese patients group, where the activity and concentration of ceruloplasmin oxidase rose in 76.112 % and 68.869 % (at p < 0.05) of the total cases of patients. The Person's correlation demonstrated significant positive relationship in those of obese patients (r = 0.828 at p < 0.005), But not in those of controls group. Conclusion: MDA levels is affected during the overweight gain; and they correlated directly to BMI. Cp acts as acute phase protein in response to weight gain, in addition to its an antioxidant role to accommodate the overflow of electrons (free radicals) formed during the process of obesity.
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