Instrumentation of curved root canals is still a challenge even for skilled and experienced operators. During shaping of these canals, canal transportation, straightening, or canal deviation may occur. This paper describes different preparation outcomes as possible results of canal transportation, and the action of different root canal instruments when used in curved canals, and provides an overview of current in vitro and in vivo studies assessing canal transportation. In the second part of this paper, the clinical consequences of canal transportation such as insufficient cleaning and over‐reduction of radicular dentin are addressed. Finally, based on currently available evidence, the impact of canal transportation on the clinical outcome of root canal treatment is discussed.