Changes in retinal nerve fiber layer and optic disc algorithms by optical coherence tomography in glaucomatous Arab subjects

Abstract

PurposeTo assess the difference in retinal nerve fiber layer (RNFL) and optic disc algorithms between glaucomatous and normal Arab subjects using optical coherence tomography (OCT).MethodsRNFL thickness and optic disc parameters were obtained in 65 patients aged 50.1 ± 7.7 years. Percentage differences in all parameters were calculated and analyzed between groups.ResultsThe mean RNFL thickness around the disc and at all quadrants was significantly thinner in glaucomatous eyes than in normal eyes (P < 0.01). The greatest decrease in RNFL thickness was observed at the inferior (39.5%) and superior (39.3%) quadrants and at 1 o’clock (43%) and 5 o’clock (40%) hour sectors. Significant differences were observed between glaucomatous and control eyes in all disc parameters (P < 0.005) assessed. The disc area, cup area, mean cup/disc ratio, and vertical and horizontal cup/disc ratios were significantly larger (P < 0.01), whereas the vertical integrated rim area, horizontal integrated rim width, and rim area were significantly smaller (P < 0.001) in glaucomatous eyes than in normal eyes.ConclusionStratus OCT is still a valuable tool in the diagnosis of early glaucoma changes and, as such, its use should be encouraged in glaucoma clinics in Saudi Arabia. The best OCT parameters for detecting early glaucoma change were RNFL thickness in the inferior, superior, and 1 o’clock hour sector; the cup area; and the vertical integrated rim area of the optic disc.

Retinal nerve fiber layer thickness in a healthy Turkish population measured by optical coherence tomography

“…In the studies by Repka and Quigly, Nilforoushan and Ahadi, and Pakravan et al, no significant correlations were observed between age and RNFL thickness. 20 – 23 In the current study, there was no significant difference in average RNFL thickness between male and female subjects, which is compatible with other reports. 5 , 13 , 14 , 20 , 24 Wong et al 25 reported significantly thicker RNFL values in men, and suggested that this finding was because of men’s higher body mass index.…”

Reliability and Recommended Settings for Pediatric Circumpapillary Retinal Nerve Fiber Layer Imaging Using Hand-Held Optical Coherence Tomography

“…Acquiring a scan of the entire optic nerve region is more difficult in children and automatic segmentation is not widely available. The advantage of volumetric imaging of the optic nerve region over single B-scan analysis, however, is that it captures arcuate retinal nerve fiber bundles in the superior and inferior quadrants, 12 , 13 often most susceptible to damage in optic nerve pathologies. It is not clear how feasible and reliable acquisition and analysis of the entire cpRNFL is in awake children.…”