Retinal nerve fiber layer thickness in a healthy Turkish population measured by optical coherence tomography

Çubuk, Mehmet Özgür; Şahinoğlu-Keşkek, Nedime; Keşkek, Şakir Özgür

doi:10.5144/0256-4947.2016.409

Cited by 7 publications

(3 citation statements)

References 26 publications

(25 reference statements)

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“…In our research, a relationship between age of participants, AxL, and RNFL was detected, but it was not statistically significant. Compared to the investigation of M. Cubuk et al, no statistically significant correlations were also found between age and RNFL in ophthalmologically healthy adults [28]. In our study, we observed that FD% values in the C 1 , C 2.5 , and R 1.5 sectors were similar between the 3 × 3-mm and 6 × 6-mm scans.…”

Section: Discussioncontrasting

confidence: 84%

Determination of Referential Rates for Optical Coherence Tomography and Optical Coherence Tomography Angiography Flow Deficits in the Macular Choriocapillaris in Ophthalmologically Healthy Children

et al. 2020

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Background and Objectives: Despite the growing number of new research publications, normative references for children’s optical coherence tomography (OCT) parameters are still not completed. We chose to explore this topic because of the lack of normative parameters that is due to an improvement in different technologies and instruments. Our aim was to determine referential rates of retinal nerve fiber layer (RNFL) thickness and flow deficits (FD%) in the macular choriocapillaris (CC) in normal eyes of ophthalmologically healthy children. Materials and Methods: Ophthalmologically healthy 8- to 14-year-old individuals participated (n = 75) in this study. OCT images were taken using an swept-source-OCT (SS-OCT) instrument (DRI-OCT Triton, Topcon, Tokyo, Japan). The early treatment diabetic retinopathy study (EDTRS) grid (6 × 6 mm) divided the RNFL into the thickness maps. The FD% values of the CC were calculated on the 3 × 3-mm scans in a 1-mm circle (C1), 1.5-mm rim (R1.5), and the entire 2.5-mm circle (C2.5), and on the 6 x 6-mm scans in a 1-mm circle (C1), 1.5-mm rim (R1.5), the entire 2.5-mm circle (C2.5), 2.5-mm rim (R2.5), and 5-mm circle (C5). Results: Both scan quantifications of FD% in the C1, C2.5, and R1.5 sectors were similar, but the 6 × 6-mm scan measurements were statistically significantly smaller than the 3 × 3-mm ones. Significant moderate correlations were found between axial length (AxL) and FD% in the 6 × 6-mm scans, namely C1 (r = −0.347, p = 0.002), C2.5 (r = −0.337, p = 0.003), R1.5 (r = −0.328, p = 0.004), R2.5 (r = −0.306, p = 0.008), and C5 (r = −0.314, p = 0.006). Conclusions: The thinnest RNFL layers were on the temporal and nasal sides. FD% values in the C1, C2.5, and R1.5 sectors were similar between the 3 × 3-mm and 6 × 6-mm scans. The negative moderate correlations between AxL and FD% were found in all C1, C2.5, C5, R1.5, and R2.5 sectors of the 6 × 6-mm scans. Further prospective studies are needed to determine more accurate normative references for children’s OCT parameters.

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Section: Discussioncontrasting

confidence: 84%

Determination of Referential Rates for Optical Coherence Tomography and Optical Coherence Tomography Angiography Flow Deficits in the Macular Choriocapillaris in Ophthalmologically Healthy Children

et al. 2020

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“…It is known that structural damage be ahead of visual field loss detected by standard perimetry. So quantitative analysis of RNFL and ONH is more reliable way of glaucoma assessment [ 11 ]. Ishkawa et al measured macular sub layer thickness and showed that macular ganglion cell complex was thinner in eyes with perimetric glaucoma [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

Diagnostic performance of optical coherence tomography macular ganglion cell inner plexiform layer and retinal nerve fiber layer thickness in glaucoma suspect and early glaucoma patients at St. Paul’s hospital millennium medical college, Addis Ababa, Ethiopia

Abera

Gessesse

2023

PLoS ONE

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Purpose To evaluate glaucoma diagnostic performance of ganglion cell inner plexiform layer and retinal nerve fiber layer parameters measured with cirrus HD optical coherence tomography (OCT). Method Total of 188 eyes were included in our study. 49 eyes of healthy controls, 70 glaucoma suspect eyes and 69 early glaucomatous eyes. Complete ophthalmic examination was done including visual field test (with Humphrey field analyzer) and OCT scanning of ganglion cell inner plexiform layer (GCIPL) and retinal nerve fiber layer (RNFL) in different quadrants. Sensitivity, specificity and area under the receiver operating characteristic curve (AUROC) of each parameter was calculated to provide diagnostic ability between normal controls, glaucoma suspects or early glaucoma. Result GCIPL and RNFL parameters had strong power in discriminating early glaucoma from healthy controls with all having AUROC of above 0.76. Of all the GCIPL and RNFL parameters, the only variable that could discriminate between glaucoma suspect and healthy controls was the combined parameter by OR-logic approach. Of all the parameters, the average and nasal RNFL parameters had the strongest power in discriminating between the two with AUROC of 0.81. All parameters had an overall good diagnostic performance with excellent sensitivity but the specificity was relatively poor. The combined parameter had the best specificity (62.2%) with excellent sensitivity (93.5%). Conclusion Nasal RNFL parameters had the strongest power in discriminating between glaucoma suspect and healthy controls and the OR-logic combination of RNFL and GCIPL provides better diagnostic performance than single GCIPL, RNFL or ONH parameter.

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“…A normal OCT database is required for different subsets of the population, which can vary depending upon racial or ethnic differences. 19 However, no normal OCT database is commercially available for the Turkish population. Thus, we aimed to describe the normative database of PPAA in Caucasian Turkish population aged between 18 and 80 years.…”

Section: Discussionmentioning

confidence: 99%

Normative posterior pole asymmetry analysis data in healthy Caucasian population

Altan

Arman

Arici

et al. 2018

European Journal of Ophthalmology

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Retinal nerve fiber layer thickness in a healthy Turkish population measured by optical coherence tomography

Cited by 7 publications

References 26 publications

Determination of Referential Rates for Optical Coherence Tomography and Optical Coherence Tomography Angiography Flow Deficits in the Macular Choriocapillaris in Ophthalmologically Healthy Children

Determination of Referential Rates for Optical Coherence Tomography and Optical Coherence Tomography Angiography Flow Deficits in the Macular Choriocapillaris in Ophthalmologically Healthy Children

Diagnostic performance of optical coherence tomography macular ganglion cell inner plexiform layer and retinal nerve fiber layer thickness in glaucoma suspect and early glaucoma patients at St. Paul’s hospital millennium medical college, Addis Ababa, Ethiopia

Normative posterior pole asymmetry analysis data in healthy Caucasian population

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