Changes in resting-state connectivity in pediatric temporal lobe epilepsy

Grassia, Fabio; Poliakov, Andrew; Poliachik, Sandra L.; Casimo, Kaitlyn; Friedman, Seth D.; Shurtleff, Hillary A.; Giussani, Carlo; Novotny, Edward J.; Ojemann, Jeffrey G.; Hauptman, Jason S.

doi:10.3171/2018.3.peds17701

Cited by 9 publications

(5 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Here we addressed the functional brain connectivity of adult animals with SE in the developing brain. Although connectivity in the default mode network is frequently reported as altered in epileptic patients as well as animal models with epilepsy induced in adulthood ( Centeno and Carmichael, 2014 ; Cui et al, 2018 ; Gill et al, 2017 ; Grassia et al, 2018 ; Haneef et al, 2014 ), our analysis did not show any significant change in the connectivity of these regions. The reason for this discrepancy might be the low number of subjects in the fMRI analysis, which involved only seven SE animals and seven controls due to the presence of the artefacts from the urethane sleep-like state transitions and motion-related artefacts that we were not able to subtract from the fMRI signal of the remaining animals.…”

Section: Discussioncontrasting

confidence: 80%

Infantile status epilepticus disrupts myelin development

Bencúrová¹,

Laakso²,

Salo³

et al. 2022

Neurobiology of Disease

View full text Add to dashboard Cite

Section: Discussioncontrasting

confidence: 80%

Infantile status epilepticus disrupts myelin development

Bencúrová¹,

Laakso²,

Salo³

et al. 2022

Neurobiology of Disease

View full text Add to dashboard Cite

“…The most commonly used method is the seed-based analysis, which estimates changes in BOLD signal of a particular region of interest to the whole-brain connectivity. Several pediatric studies have demonstrated evidence that patterns of RSN can change in various epileptic diseases, such as absence [113] and partial epilepsy [114], including temporal lobe epilepsy [115], showing mostly decreased connectivity compared to a group of healthy control subjects. The connectivity changes observed in such group analyses encouraged investigators to apply rs-fMRI in the clinical practice and report preliminary experiences in individual patients [116][117][118].…”

Section: Resting-state Fmrievaluation Of Brain Connectivitymentioning

confidence: 99%

Utility of MRI, PET, and ictal SPECT in presurgical evaluation of non-lesional pediatric epilepsy

Juhász

John

2020

Seizure

View full text Add to dashboard Cite

Children with epilepsy and normal structural MRI pose a particular challenge in localization of epileptic foci for surgical resection. Many of these patients have subtle structural lesions such as mild cortical dysplasia that can be missed by conventional MRI but may become detectable by optimized and advanced MRI acquisitions and post-processing. Specificity of objective analytic techniques such as voxel-based morphometry remains an issue. Combination of MRI with functional imaging approaches can improve the accuracy of detecting epileptogenic brain regions. Analysis of glucose positron emission tomography (PET) combined with high-resolution MRI can optimize detection of hypometabolic cortex associated with subtle cortical malformations and can also enhance presurgical evaluation in children with epileptic spasms. Additional PET tracers may detect subtle epileptogenic lesions and cortex with enhanced specificity in carefully selected subgroups with various etiologies; e.g., increased tryptophan uptake can identify epileptogenic cortical dysplasia in the interictal state. Subtraction ictal SPECT can be also useful to delineate ictal foci in those with non-localizing PET or after failed surgical resection. Presurgical delineation of language and motor cortex and the corresponding white matter tracts is increasingly reliable by functional MRI and DTI techniques; with careful preparation, these can be useful even in young and sedated children. While evidence-based pediatric guidelines are still lacking, the data accumulated in the last decade strongly indicate that multimodal imaging with combined analysis of MRI, PET, and/or ictal SPECT data can optimize the detection of subtle epileptogenic lesions and facilitate seizure-free outcome while minimizing the postsurgical functional deficit in children with normal conventional MRI.

show abstract

“…Despite our limited understanding of the network effects of epilepsy, the potential clinical utility is expanding. Direct applications are most apparent in surgical epilepsies where network approaches have already demonstrated utility in identifying the epileptogenic region for resection and predicting postoperative outcomes of both seizure freedom and functional deficits . Pertaining to the nonsurgical childhood epilepsies, an understanding of network effects has the potential to yield new biomarkers including, as already demonstrated in one study, the possibility of predicting medication refractoriness .…”

Section: Discussionmentioning

confidence: 99%

The epileptic network and cognition: What functional connectivity is teaching us about the childhood epilepsies

2019

View full text Add to dashboard Cite

Our objective was to summarize and evaluate the rapidly expanding body of literature studying functional connectivity in childhood epilepsy. In the self‐limited childhood epilepsies, awareness of cognitive comorbidities has been steadily increasing, and recent advances in our understanding of the network effects of these disorders promise insights into the underlying neurobiology. We reviewed publications addressing functional connectivity in children with epilepsy with an emphasis on studies of children with self‐limited childhood epilepsies. The majority of studies have been published in the past 10 years and predominantly examine childhood epilepsy with centrotemporal spikes and childhood absence epilepsy. Cognitive network alterations are commonly observed across the childhood epilepsies. Some of these effects appear to be nonspecific to epilepsy syndrome or even to category of neurological disorder. Other patterns, such as changes in the connectivity of cortical language areas in childhood epilepsy with centrotemporal spikes, provide clues to the underlying cognitive deficits seen in affected children. The literature to date is dominated by general observations of connectivity patterns without a priori hypotheses. These data‐driven studies build an important foundation for hypothesis generation and are already providing useful insights into the neuropathology of the childhood epilepsies. Future work should emphasize hypothesis‐driven approaches and rigorous clinical correlations to better understand how the knowledge of network alterations can be applied to guidance and treatment for the children in our clinics.

show abstract

Changes in resting-state connectivity in pediatric temporal lobe epilepsy

Cited by 9 publications

References 17 publications

Infantile status epilepticus disrupts myelin development

Infantile status epilepticus disrupts myelin development

Utility of MRI, PET, and ictal SPECT in presurgical evaluation of non-lesional pediatric epilepsy

The epileptic network and cognition: What functional connectivity is teaching us about the childhood epilepsies

Contact Info

Product

Resources

About