Infantile status epilepticus disrupts myelin development

Bencúrová, Petra; Laakso, Hanne; Salo, Raimo A.; Paasonen, Ekaterina; Manninen, Eppu; Paasonen, Jaakko; Michaeli, Shalom; Mangia, Silvia; Bareš, Martin; Brázdil, Milan; Kubová, Hana; Gröhn, Olli

doi:10.1016/j.nbd.2021.105566

Cited by 4 publications

(1 citation statement)

References 78 publications

(118 reference statements)

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“…Zebrafish and Xenopus have myelinated axons and are used as models for demyelination [ 70 , 71 , 72 , 73 , 74 , 75 ]. Aquatic freshwater vertebrate models of demyelination are particularly useful given that children with epilepsy have abnormal myelin development [ 76 , 77 ] and patients with demyelinating disease also suffer from seizures [ 78 ]. Lastly, zebrafish and Xenopus use gamma-aminobutyric acid (GABA) and glutamate receptors to control CNS activity including signaling required for movement [ 79 , 80 , 81 , 82 , 83 ].…”

Section: Aquatic Freshwater Vertebrate Animal Model Advantagesmentioning

confidence: 99%

Aquatic Freshwater Vertebrate Models of Epilepsy Pathology: Past Discoveries and Future Directions for Therapeutic Discovery

Williams¹,

Mruk²

2022

IJMS

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Epilepsy is an international public health concern that greatly affects patients’ health and lifestyle. About 30% of patients do not respond to available therapies, making new research models important for further drug discovery. Aquatic vertebrates present a promising avenue for improved seizure drug screening and discovery. Zebrafish (Danio rerio) and African clawed frogs (Xenopus laevis and tropicalis) are increasing in popularity for seizure research due to their cost-effective housing and rearing, similar genome to humans, ease of genetic manipulation, and simplicity of drug dosing. These organisms have demonstrated utility in a variety of seizure-induction models including chemical and genetic methods. Past studies with these methods have produced promising data and generated questions for further applications of these models to promote discovery of drug-resistant seizure pathology and lead to effective treatments for these patients.

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