Changes in respiration, heart rate, and systolic blood pressure in human sleep

Snyder, Frederick; Hobson, J. Allan; Morrison, Donald F.; Goldfrank, Frederick

doi:10.1152/jappl.1964.19.3.417

Cited by 481 publications

(125 citation statements)

References 0 publications

Supporting

Mentioning

111

Contrasting

Unclassified

Order By: Relevance

“…Like in previous studies (Khatri and Freis 1966;Snyder et al 1964;Somers et al 1993), subjects showed various MAP time courses during REM sleep, the averaged levels being either increased, decreased or unchanged. A true representation of the variations of ABP cannot be obtained by calculating mean levels, because of the large swings of ABP during REM sleep.…”

Section: Discussionsupporting

confidence: 69%

“…The ABP also displays notable variations according to sleep stages. Previous studies have reported averaged blood pressure levels during the di erent sleep stages and found that NREM sleep is characterized by low ABP levels (A5 to A15 mmHg compared with waking levels), in contrast to REM sleep during which mean ABP values reach those recorded during awakening (Bristow et al 1969;Khatri and Freis 1966;Snyder et al 1964;Somers et al 1993). The low variability of ABP during SWS was opposed to the marked and irregular¯uctuations during REM sleep in most of these studies.…”

Section: Discussionmentioning

confidence: 84%

“…These ®ndings suggest that common central mechanisms, possibly involving the serotoninergic system (Rittenhouse et al 1992; Van de Kar et al 1981, 1987, control both the alternation of the sleep stages and renin release from the juxtaglomerular cells. However, previous studies have reported a reduction in averaged blood pressure levels during NREM sleep and a high variability with a slight enhancement during REM sleep (Khatri and Freis 1966;Snyder et al 1964). In rats, sleep-stage associated blood pressure variations have been reported together with opposing PRA changes (Obal et al 1994;Obal and Krueger 1999).…”

Section: Introductionmentioning

confidence: 97%

See 2 more Smart Citations

Time‐courses in renin and blood pressure during sleep in humans

Charloux¹,

Piquard²,

Ehrhart³

et al. 2002

Journal of Sleep Research

View full text Add to dashboard Cite

SUMMARY We previously described a strong concordance between nocturnal oscillations in plasma renin activity (PRA) and the rapid eye movement (REM) and non-REM (NREM) sleep cycles, but the mechanisms inducing PRA oscillations remain to be identi®ed. This study was designed to examine whether they are linked to sleep stage-related changes in arterial blood pressure (ABP). Analysis of sleep electroencephalographic (EEG) activity in the delta frequency band, intra-arterial pressure, and PRA measured every 10 min was performed in eight healthy subjects. Simultaneously, the ratio of low frequency power to low frequency power + high frequency power [LF/(LF + HF)] was calculated using spectral analysis of R±R intervals. The cascade of physiological events that led to increased renin release during NREM sleep could be characterized. First, the LF/(LF + HF) ratio signi®cantly (P < 10 A4 ) decreased, indicating a reduction in sympathetic tone, concomitantly to a signi®cant (P < 10 A3 ) decrease in mean arterial pressure (MAP). Delta wave activity increased (P < 10 A4 ) 10±20 min later and was associated with a lag of 0±10 min with a signi®cant rise in PRA (P < 10 A4 ). Rapid eye movement sleep was characterized by a signi®cant increase (P < 10 A4 ) in the LF/(LF + HF) ratio and a decrease (P < 10 A4 ) in delta wave activity and PRA, whereas MAP levels were highly variable. Overnight cross-correlation analysis revealed that MAP was inversely correlated with delta wave activity and with PRA (P < 0.01 in all subjects but one). These results suggest that pressure-dependent mechanisms elicit the nocturnal PRA oscillations rather than common central processes controlling both the generation of slow waves and the release of renin from the kidney.

show abstract

Section: Discussionsupporting

confidence: 69%

Section: Discussionmentioning

confidence: 84%

Section: Introductionmentioning

confidence: 97%

See 1 more Smart Citation

Time‐courses in renin and blood pressure during sleep in humans

Charloux¹,

Piquard²,

Ehrhart³

et al. 2002

Journal of Sleep Research

View full text Add to dashboard Cite

show abstract

“…Based on the percentage difference between daytime and night-time SBP, the study population was divided into 'dippers' and 'nondippers' (respectively X or o10%). [17][18][19] Arterial hypertension was diagnosed following the Joint National Committee VII cutoff values (systolic and/or diastolic OBPX140/90 mmHg; systolic and/or diastolic daytime ABPMX135/85 mmHg). 20 …”

Section: Methodsmentioning

confidence: 99%

Isolated ambulatory hypertension is common in outpatients referred to a hypertension centre

et al. 2004

View full text Add to dashboard Cite

The present investigation was aimed at determining the prevalence and the blood pressure (BP) profile of isolated ambulatory hypertension, defined as an elevated ambulatory BP with normal office blood pressure, in a series of 1488 consecutive outpatients referred for routine clinical evaluation of suspected or established arterial hypertension. All patients underwent both office BP (OBP) measurement by a physician and 24-h ambulatory blood pressure monitoring (ABPM). Using OBP values (cutoff for diagnosis of hypertension X140/ 90 mmHg) and daytime ABPM (cutoff for diagnosis of hypertension X135/85 mmHg), patients were classified into eight subgroups. In the whole series we found that, independent of treatment status, the prevalence of isolated ambulatory hypertension exceeded 10%. More importantly, 45.3% of individuals who presented with normal OBP values, showed elevated BP at ABPM. Night-time BP, 24-h pulse pressure, and BP variability were significantly higher in isolated ambulatory hypertensives than in normotensive or in white-coat hypertensive individuals. Therefore, isolated ambulatory hypertension is characterized by a blood pressure profile that is similar to that observed in sustained hypertension. These findings suggest that isolated ambulatory hypertension is very common and probably the indications for ABPM should be more extensive in outpatients referred to hypertensive centre.

show abstract

“…It was also observed that: (1) the peak was reached in early evening; (2) the influence of age on blood pressure values was undefined (Richardson et ul., 1964), and a correlation between encephalographic evidence of depth of sleep and the magnitude of blood pressure decrease was present (Richardson et al, 1964;Snyder et al, 1964).…”

Section: Introductionmentioning

confidence: 99%

Detection of a diurnal rhythm in arterial blood pressure in the evaluation of 24‐hour antihypertensive therapy

Germanò¹,

Ciavarella²,

Appolloni³

et al. 1984

Clinical Cardiology

View full text Add to dashboard Cite

Summary:Uncertainty in defining hypertensive disease makes a prolonged study of blood pressure pattern necessary, using continuous or semicontinuous blood pressure recordings. Its pathophysiological meaning involves data sufficiently indicative of blood pressure profile with reference to the continuous stimulations of different intensity and duration, which are met by subjects both in their daily activities and in the passage from an active life to sleep. Such a parameter is, in fact, an indispensable premise for a correct course of therapy. The aim of our work was at first the detection of a diurnal rhythm in blood pressure, using data obtained in a 24-h ambulatory monitoring away from the conditioning of different activities and daily routine. We have employed three groups of 34 males each. The first group consisted of hypertensive outpatients, while hospitalized subjects comprised the second group. Thethird group was composed of normal subjects. Furthermore, after finding this system productive, we started studying whether this rhythm of blood pressure could be modified under the influence of a single administered drug dose, and whether information obtained could be easily interpreted. We studied 12 male patients with essential hypertension, which had been untreated. Each patient underwent three 24-h blood pressure ambulatory monitorings. Two different doses of nifedipine (10 and 20 mg) were randomly administered to each of the patients at the beginning of the second and third readings. We observed a significant fall in systolic blood pressure and a minor decrease in diastolic blood pressure after administration of a single 10 mg nifedipine tablet.

show abstract

Changes in respiration, heart rate, and systolic blood pressure in human sleep

Cited by 481 publications

References 0 publications

Time‐courses in renin and blood pressure during sleep in humans

Time‐courses in renin and blood pressure during sleep in humans

Isolated ambulatory hypertension is common in outpatients referred to a hypertension centre

Detection of a diurnal rhythm in arterial blood pressure in the evaluation of 24‐hour antihypertensive therapy

Contact Info

Product

Resources

About