“…Mechanistically, biopsy-proven episodic glomerular hemorrhage could play a role. Although renal function seems to be differentially affected by DE and warfarin, the efficacy and safety of DE(33), as well as other novel anticoagulants(34), in preventing stroke were better or similar compared with warfarin.Furthermore, previous impaired renal function is associated with reoccurrence of AF(35). Thus, changing the quality of AF by renal function also could have had an effect on outcomes.CENTRAL ILLUSTRATION Vascular Calcification, Arterial Damage, and Decline in Renal Function May Be Triggered by the Inhibition of the Vitamin K-Dependent Protein Matrix Gammacarboxyglutamic Acid (Gla/MGP) by Vitamin K Antagonists Böhm, M. et al J Am Coll Cardiol.…”