Elevated plasma norepinephrine level and sick sinus syndrome in patients with lone atrial fibrillation

Abstract

An increase in plasma NE level was observed in patients with AF and SSS. Although this implies a pathophysiological link between clinical manifestation of SSS and the autonomic nervous dysfunction, further studies are needed to clarify the mechanisms for this novel finding.

Score Using Measurements of Plasma Midregional Pro–Atrial Natriuretic Peptide to Estimate the Duration of Atrial Fibrillation

“…The MR-proANP concentrations in patients presenting with recent-onset AF were lower than in patients presenting with more prolonged AF, in agreement with previous studies (14,15,24). This finding is consistent with the mechanism of prolonged elevation of atrial pressure and wall stretch promoting the production of MR-proANP (14).…”

Autonomic nervous system modulation and clinical outcome after pulmonary vein isolation using the second‐generation cryoballoon

“…As well as the prior studies, 5,6,[8][9][10] we interpreted that the changes in the HR and blood pressure were derived from the impact of the ablation on the ANS; however, these changes might not reflect the change in the autonomic activity in patients with subclinical sinus node dysfunction, which is likely concomitant with AF. 21 Indeed, the presence of autonomic remodeling was shown in animal models in a prior study. 22 The -blocker administration might have influenced the HR analysis in a part of the patients.…”

Underrecognized entity of the transient rise in the atrial capture threshold early after dual‐chamber pacemaker implantation

“…If inflammation plays a key role in TRACT, phase 4 block should also transiently occur. A previous study reported that the plasma norepinephrine level was higher in patients with SSS and AF than in patients with AF alone . The ability of catecholamine to induce phase 4 depolarization and the strong relation observed between TRACT and SSS may also support phase 4 depolarization or block as a possible mechanism of TRACT in this retrospective series although bradycardia dependency was not evaluated.…”