Changes in Regional Homogeneity of Medication-Free Major Depressive Disorder Patients With Different Onset Ages

Zhang, Zijian; Chen, Ya-Yun; Wei, Wei; Yang, Xiao; Meng, Yajing; Yu, Hua; Guo, Wanjun; Wang, Qiang; Deng, Wei; Li, Tao; Ma, Xiaoyan

doi:10.3389/fpsyt.2021.713614

Cited by 9 publications

(8 citation statements)

References 71 publications

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“…Decreased ReHo values were observed in the left precentral gyrus and were positively correlated with EPQ-N scores and negatively correlated with EPQ-L scores in the patients. Reduced ReHo values of the left precentral gyrus in patients with MDD have been found in the published literature (Zhang et al, 2021;Song et al, 2022). Previous studies have shown that patients with MDD who attempted suicide had fewer hemodynamic responses in the left precentral gyrus than patients with MDD without suicidal ideation and HCs (Tsujii et al, 2017).…”

Section: Discussionmentioning

confidence: 85%

Multiple examinations indicated associations between abnormal regional homogeneity and cognitive dysfunction in major depressive disorder

Wang

Li²,

Yan³

et al. 2023

Front. Psychol.

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BackgroundThis study aimed to investigate the relationships between regional neural activity and multiple related indicators in patients with major depressive disorder (MDD).MethodsForty-two patients and 42 healthy controls (HCs) were enrolled. Pearson/Spearman correlation analyses were applied to examine the associations between abnormal regional homogeneity (ReHo) and different indicators in the patients.ResultsCompared with HCs, patients with MDD had increased ReHo in the left inferior temporal gyrus (ITG) and decreased ReHo values in the left putamen, anterior cingulate cortex (ACC), and precentral gyrus. The ReHo of the left putamen was positively correlated with the PR interval, Repeatable Battery for the Assessment of Neuropsychological Status 4A, and Discriminant analysis (D), and negatively correlated with Ae (block) and Ae (total) in the patients. The ReHo value of the left ACC was positively correlated with the severity of depression, Stroop Color Word Test of C − 2B + 100 in reaction time, and negatively correlated with Ce (Missay) and Perseverative Responses in the patients. The ReHo of the left ITG was positively correlated with the Neuroticism scores and negatively correlated with the Lie scores in the patients.ConclusionThese results suggested that the decreased ReHo of the salience network might be the underpinning of cognitive impairments in patients with MDD.

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Section: Discussionmentioning

confidence: 85%

Multiple examinations indicated associations between abnormal regional homogeneity and cognitive dysfunction in major depressive disorder

Wang

Li²,

Yan³

et al. 2023

Front. Psychol.

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“…In this study, POPP patients also had greater ALFF values in the right triangular inferior frontal gyrus. Previous studies had shown that early onset depression had more abnormal prefrontal ReHo values than late-onset depression, and the neuropathological mechanism of recurrent depressive episode was more complex than that of first depressive episode, but both of them were dominated by abnormalities of the right inferior frontal gyrus (triangular part) [33,34]. This suggested that the right triangular inferior frontal gyrus was involved in the process of depression.…”

Section: Discussionmentioning

confidence: 96%

Association between aberrant brain activity and pain in patients with primary osteoporotic pain: a resting-state fMRI study

Guo

Yang

et al. 2023

Preprint

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Introduction: Primary osteoporotic pain (POPP) seriously affects the life of patients. Although chronic pain is associated with altered central nervous activity, the central pathological mechanism of POPP is still unclear. This study aimed to explore the differences of brain activity between POPP patients and healthy controls (HCs), as well as the correlations between altered brain regions and pain. Method: Magnetic resonance imaging data (MRI) and visual analogue scale (VAS) scores of subjects were collected. MRI data were preprocessed and then regional homogeneity (ReHo) and amplitude of low-frequency fluctuation (ALFF) values of brain regions were calculated. ReHo and ALFF values were compared between groups. Result: (1) Compared with HCs, reduced ReHo values were found in the left medial superior frontal gyrus, middle frontal gyrus, opercular part of inferior frontal gyrus and right dorsolateral superior frontal gyrus of POPP patients. (2) Reduced ALFF values were identified in the left dorsolateral superior frontal gyrus, medial superior frontal gyrus, orbital part of middle frontal gyrus, opercular part of inferior frontal gyrus and right dorsolateral superior frontal gyrus. (3) Negative correlations were identified between ReHo values of the left middle frontal gyrus and VAS scores in the patient group. Conclusion：The prefrontal dysfunction may be related to the occurrence of POPP. In addition, the left middle frontal gyrus can be used as an indicator to evaluate the severity of pain in patients with POPP. These findings help us to further understand the pathogenesis of POPP from the perspective of neuroimaging.

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“…Further, it was also associated with the early-onset depression (EOD) and late -onset depression (LOD). Zhang et al ( 40 ) found the EOD patients exhibited increased activation in the right triangular IFG compared with the LOD patients. They indicated that the specific brain alterations of EOD and LOD patients could be associated with different clinical symptoms.…”

Section: Discussionmentioning

confidence: 99%

Abnormal brain spontaneous activity in major depressive disorder adolescents with non-suicidal self injury and its changes after sertraline therapy

Dai

Zhang

et al. 2023

Front. Psychiatry

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BackgroundNon-suicidal self-injury (NSSI) commonly occurs among adolescents with major depressive disorder (MDD), causing adverse effects on the physical and mental health of the patients. However, the underlying neurobiological mechanism of NSSI in adolescents with MDD (nsMDDs) remains unclear, and there are still challenges in the treatment. Studies have suggested that sertraline administration could be an effective way for treatment.MethodsTo verify the effectiveness and to explore the neurobiological processes, we treated a group of adolescents with nsMDDs with sertraline in this study. The brain spontaneous activity alteration was then investigated in fifteen unmedicated first-episode adolescent nsMDDs versus twenty-two healthy controls through the resting-state functional magnetic resonance imaging. Besides the baseline scanning for all participants, the nsMDDs group was scanned again after eight weeks of sertraline therapy to examine the changes after treatment.ResultsAt pre-treatment, whole brain analysis of mean amplitude of low-frequency fluctuation (mALFF) was performed to examine the neuronal spontaneous activity alteration, and increased mALFF was found in the superior occipital extending to lingual gyrus in adolescent nsMDDs compared with controls. Meanwhile, decreased mALFF was found in the medial superior frontal in adolescent nsMDDs compared with controls. Compared with the pre-treatment, the nsMDDs group was found to have a trend of, respectively, decreased and increased functional neuronal activity at the two brain areas after treatment through the region of interest analysis. Further, whole brain comparison of mALFF at pre-treatment and post-treatment showed significantly decreased spontaneous activity in the orbital middle frontal and lingual gyrus in adolescent nsMDDs after treatment. Also, depression severity was significantly decreased after treatment.ConclusionThe abnormal functional neuronal activity found at frontal and occipital cortex implied cognitive and affective disturbances in adolescent nsMDDs. The trend of upregulation of frontal neuronal activity and downregulation of occipital neuronal activity after sertraline treatment indicated that the therapy could be effective in regulating the abnormality. Notably, the significantly decreased neuronal activity in the decision related orbital middle frontal and anxiety-depression related lingual gyrus could be suggestive of reduced NSSI in adolescent MDD after therapy.

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Changes in Regional Homogeneity of Medication-Free Major Depressive Disorder Patients With Different Onset Ages

Cited by 9 publications

References 71 publications

Multiple examinations indicated associations between abnormal regional homogeneity and cognitive dysfunction in major depressive disorder

Multiple examinations indicated associations between abnormal regional homogeneity and cognitive dysfunction in major depressive disorder

Association between aberrant brain activity and pain in patients with primary osteoporotic pain: a resting-state fMRI study

Abnormal brain spontaneous activity in major depressive disorder adolescents with non-suicidal self injury and its changes after sertraline therapy

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