Multiple examinations indicated associations between abnormal regional homogeneity and cognitive dysfunction in major depressive disorder

Abstract

BackgroundThis study aimed to investigate the relationships between regional neural activity and multiple related indicators in patients with major depressive disorder (MDD).MethodsForty-two patients and 42 healthy controls (HCs) were enrolled. Pearson/Spearman correlation analyses were applied to examine the associations between abnormal regional homogeneity (ReHo) and different indicators in the patients.ResultsCompared with HCs, patients with MDD had increased ReHo in the left inferior temporal gyrus (ITG) and decreased ReHo values in the left putamen, anterior cingulate cortex (ACC), and precentral gyrus. The ReHo of the left putamen was positively correlated with the PR interval, Repeatable Battery for the Assessment of Neuropsychological Status 4A, and Discriminant analysis (D), and negatively correlated with Ae (block) and Ae (total) in the patients. The ReHo value of the left ACC was positively correlated with the severity of depression, Stroop Color Word Test of C − 2B + 100 in reaction time, and negatively correlated with Ce (Missay) and Perseverative Responses in the patients. The ReHo of the left ITG was positively correlated with the Neuroticism scores and negatively correlated with the Lie scores in the patients.ConclusionThese results suggested that the decreased ReHo of the salience network might be the underpinning of cognitive impairments in patients with MDD.

Neural Functioning in Late-Life Depression: An Activation Likelihood Estimation Meta-Analysis

“…The neural functioning of the left putamen has also been implicated in the risk of bipolar disorder onset, suggesting a potential marker of vulnerability [ 99 ], as well as suicidality in bipolar II disorder [ 100 ]. Our results are consistent with decreased putamen regional homogeneity reported in adult patients with MDD [ 101 , 102 ], and with a recent SPECT study that showed negative correlation between levels of depression, anxiety, anhedonia and psychomotor retardation and DAT availability in the left putamen [ 103 ]. The same study showed lower left putamen DAT availability in seriously depressed patients and in patients with significant psychomotor retardation [ 103 ].…”