2008
DOI: 10.1002/gps.1980
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Changes in regional cerebral blood flow following antidepressant treatment in late‐life depression

Abstract: Remarkable improvements in rCBF in the left dorsolateral PFC to precentral regions are consistent with the hypothesis that neuronetworks including the left frontal cortex may be functionally and reversibly involved in late-life unipolar major depression (state-dependent). In contrast, neural circuits including bilateral medial, dorsolateral, and parietal areas may reflect underlying and continuous pathognomonic brain dysfunction of depression (trait-dependent).

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Cited by 58 publications
(34 citation statements)
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“…Both disorders result in cognitive impairment. Similar cortical networks and neurotransmitter by these fi ndings, the interactions between antidepressant treatment and tinnitus may relate to antidepressant-induced modulation of frontal cortex networks (Ishizaki et al 2008), and altered top-down control of activity in the central auditory pathways.…”
Section: Synopsismentioning
confidence: 98%
“…Both disorders result in cognitive impairment. Similar cortical networks and neurotransmitter by these fi ndings, the interactions between antidepressant treatment and tinnitus may relate to antidepressant-induced modulation of frontal cortex networks (Ishizaki et al 2008), and altered top-down control of activity in the central auditory pathways.…”
Section: Synopsismentioning
confidence: 98%
“…75,76 Increasing brain perfusion might therefore benefit depression. Two forms of vitamin B 3 (ie, niacin and niacinamide) have therapeutic potential as antidepressants based on the 2 theories presented above.…”
Section: Depressionmentioning
confidence: 99%
“…Each of these are represented, in one form or another, in the accepted diagnostic criteria for major depression [29]. All of these brain regions receive serotonergic, noradrenergic, and/or dopaminergic projections [30], and results of neuroimaging studies indicate that depression-associated abnormalities in several of these regions may resolve following treatment with 5-HT and/or NE potentiating antidepressants [31][32][33][34]. An obvious limitation of this model is that it alone cannot explain suboptimal response to antidepressant treatment.…”
Section: Neurotransmitter Hypothesis Of Major Depression and Antideprmentioning
confidence: 99%