Changes in Protein Composition of Saliva from Radiation-induced Xerostomia Patients and Its Effect on Growth of Oral Streptococci

Cowman, R.A.; Baron, S.S.; Glassman, Andrew H.; Davis, Mike; Strosberg, A.M.

doi:10.1177/00220345830620030601

Cited by 26 publications

(8 citation statements)

References 20 publications

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“…Patients have low tolerance for dental prostheses because of tissue friability and lack of lubrication. Oral microbial populations shift, resulting in a high risk of caries and frequent occurrence of oral candidiasis [8,12,19]. Patients may also have abnormal swallowing patterns, in which the movement of a bolus from mouth to pharynx is slowed [24].…”

Section: Clinical Coursementioning

confidence: 99%

Radiation-induced xerostomia: pathophysiology, clinical course and supportive treatment

Guchelaar

Vermes

1997

Supportive Care in Cancer

151

105

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Xerostomia, or oral dryness, is one of the most common complaints experienced by patients who have had radiotherapy of the oral cavity and neck region. The hallmarks of radiation-induced damage are acinar atrophy and chronic inflammation of the salivary glands. The early response, resulting in atrophy of the secretory cells without inflammation might be due to radiation-induced apoptosis. In contrast, the late response with inflammation could be a result of radiation-induced necrosis. The subjective complaint of a dry mouth appears to be poorly correlated with objective findings of salivary gland dysfunction. Xerostomia, with secondary symptoms of increased dental caries, difficulty in chewing, swallowing and speaking, and an increased incidence of oral candidiasis, can have a significant effect on the quality of life. At present there is no causal treatment for radiation-induced xerostomia. Temporary symptomatic relief can be offered by moistening agents and saliva substitutes, and is the only option for patients without residual salivary function. In patients with residual salivary function, oral administration of pilocarpine 5-10 mg three times a day is effective in increasing salivary flow and improving the symptoms of xerostomia, and this therapy should be considered as the treatment of choice. Effectiveness of sialogogue treatment requires residual salivary function, which emphasizes the potential benefit from sparing normal tissue during irradiation. The hypothesis concerning the existence of early apoptotic and late necrotic effects of irradiation on the salivary glands theoretically offers a way of achieving this goal.

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Section: Clinical Coursementioning

confidence: 99%

Radiation-induced xerostomia: pathophysiology, clinical course and supportive treatment

Guchelaar

Vermes

1997

Supportive Care in Cancer

151

105

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“…The reduction in salivary flow results in a loss of the protective properties of saliva, a decrease of the pH of saliva and a quantita tive and qualitative shift in oral microfiora. This shift in microfiora is accompanied by a change in the pat tern of food consumption to frequent, nondetergent, high-carbohydrate meals [Del Regato, 1939;Frank et al, 1965;Brown et al, 1975Brown et al, , 1976Shannon et al, 1977Shannon et al, , 1978Cowman et al, 1983].…”

mentioning

confidence: 99%

The Effect of X-Ray Irradiation on the Demineralization of Bovine Dental Enamel

et al. 1988

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In this study the effect of X-ray irradiation on demineralization of bovine dental enamel in vitro was investigated. Enamel specimens were irradiated with 72 Gy and subsequently demineralized (140 h) under reproducible constant composition conditions at pH = 5 in the presence of methylhydroxydiphosphonate (MHDP). Microhardness measurements after demineralization without MHDP showed significant differences (p < 0.001) between irradiated and nonirradiated enamel specimens; no significant differences were found in the presence of MHDP. Quantitative microradiography showed that both mineral loss and lesion depth were significantly lower (p < 0.001) for the irradiated enamel specimens compared with the nonirradiated ones. Surface layer formation was observed in irradiated enamel demineralized in a solution without MHDP. It was shown that X-ray irradiation decreased the enamel acid solubility in vitro.

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“…It is reasonable to believe that changes in salivary secretion and changes in protein composition promote the growth of microorganisms associated with the conditions most frequently found in the oral cavity (caries, gingivitis, mucosal infections) (10)(11)(12). Electrolytes are known to be secreted in the mouth by the salivary glands, although the exudation of serum from injured oral mucosa also contributes to electrolyte concentrations found in saliva.…”

Section: Discussionmentioning

confidence: 99%

Assessing the determination of salivary electrolytes and anti-Ro and anti-La antibodies for the diagnosis of Sjogren s syndrome (SS)

Busamia¹,

Gonzales-Moles²,

Mazzeo³

et al. 2010

Med Oral

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The aim of this study was to assess changes in salivary electrolyte flow and composition and the presence of anti-Ro/SSA and anti-La/SSB serum and saliva antibodies and their implications for the non-invasive diagnosis of SS. Study design: 73 patients were studied, divided into the following experimental groups: primary Sjögren syndrome (SSp) (n=15), secondary SS (SSs) (n=17), dry mouth, dry eye without Sjögren's syndrome (BO) (n=20) and healthy controls (C) (n=21). We conducted a baseline assessment of salivary flow and saliva sampling for the measurement of sodium, chlorine, potassium, calcium and phosphate electrolytes, and the determination of antiRo/SSA and La/SSB antibodies; a serum sampling was made to assess antibody positivity. Results: Salivary flow in SSp, SSs and BO was significantly lower (p<0.001) relative to C. The salivary composition of SS showed an increase of inorganic components. Anti-Ro/SSA and anti-La/SSB antibodies occurred more frequently in serum and saliva in SS patients compared with BO and C, with higher frequency of positivity in serum compared with saliva. Conclusion: Our results suggest new tools that could aid the non-traumatic diagnosis of the origin of hyposalivation.

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Changes in Protein Composition of Saliva from Radiation-induced Xerostomia Patients and Its Effect on Growth of Oral Streptococci

Cited by 26 publications

References 20 publications

Radiation-induced xerostomia: pathophysiology, clinical course and supportive treatment

Radiation-induced xerostomia: pathophysiology, clinical course and supportive treatment

The Effect of X-Ray Irradiation on the Demineralization of Bovine Dental Enamel

Assessing the determination of salivary electrolytes and anti-Ro and anti-La antibodies for the diagnosis of Sjogren s syndrome (SS)

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