Changes in progressive ratio responding for intravenous cocaine throughout the reproductive process in female rats

Hecht, Gerald S.; Spear, Norman E.; Spear, Linda P.

doi:10.1002/(sici)1098-2302(199909)35:2<136::aid-dev6>3.0.co;2-k

Cited by 82 publications

(38 citation statements)

References 41 publications

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“…Secondly, our data suggest that the differential neurobiological responses to AMPH in SN and PB males may underlie group differences in AMPH-induced behavior. Similarly, lactating rats showed a suppression of activity within the mesocorticolimbic DA system in response to cocaine (as opposed to the increase in activity noted in virgin females) (Ferris et al, 2005) and a reduction in cocaine self-administration (Hecht et al, 1999), further supporting the notion that physiological changes associated with social experience may attenuate the rewarding properties of drugs of abuse.…”

Section: Discussionmentioning

confidence: 69%

Social Bonding Decreases the Rewarding Properties of Amphetamine through a Dopamine D1 Receptor-Mediated Mechanism

Liu¹,

Young²,

Curtis³

et al. 2011

J. Neurosci.

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Although the protective effects of social bonds on drug use/abuse have been well documented, we know little about the underlying neural mechanisms. Using the prairie vole (Microtus ochrogaster)—a socially monogamous rodent that forms long-term pair bonds after mating—we demonstrate that amphetamine (AMPH) conditioning induced a conditioned place preference (CPP) in sexually naïve (SN), but not pair-bonded (PB), males. Although AMPH treatment induced a similar magnitude of DA release in the nucleus accumbens (NAcc) of SN and PB males, it had differential effects on NAcc D1 receptor (D1R) binding. Specifically, AMPH treatment increased D1R binding in SN, but decreased D1R binding in PB males. NAcc D1R, but not D2R, antagonism blocked AMPH-induced CPP in SN males and NAcc D1R activation prior to AMPH conditioning enabled AMPH-induced CPP in PB males. Together, our data demonstrate that pair bonding experience decreases the rewarding properties of AMPH through a D1R mediated mechanism.

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Section: Discussionmentioning

confidence: 69%

Social Bonding Decreases the Rewarding Properties of Amphetamine through a Dopamine D1 Receptor-Mediated Mechanism

Liu¹,

Young²,

Curtis³

et al. 2011

J. Neurosci.

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show abstract

“…Unfortunately, similar data are not available for men. A provocative animal study showing that cocaine self-administration diminished dramatically in pregnant rodents, only to resume after pregnancy, suggests biological factors contribute to decreased consumption by women during pregnancy (Hecht, Spear, & Spear, 1999). However, mixed data on consumption of alcohol by high-drinking rat and mouse strains during pregnancy has been published with some studies showing no change and some studies showing decreases (Brady, Allan, & Caldwell, 2012; Kleiber, Wright, & Singh, 2011; Wolfe, Means, & McMillen, 2000).…”

Section: Emergence Of Sex/gender Differences In Drug Taking: Summamentioning

confidence: 99%

Emergence of sex differences in the development of substance use and abuse during adolescence

Kuhn

2015

Pharmacology & Therapeutics

140

106

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Substance use and abuse begins during adolescence. Male and female adolescent humans initiate use at comparable rates, but males increase use faster. In adulthood, more men than women use and abuse addictive drugs. However, some women progress more rapidly from initiation of use to entry into treatment. In animal models, adolescent males and females consume addictive drugs similarly. However, reproductively mature females acquire self-administration faster, and in some models, escalate use more. Sex/gender differences exist in neurobiologic factors mediating both reinforcement (dopamine, opioids) and aversiveness (CRF, dynorphin), as well as intrinsic factors (personality, psychiatric co-morbidities) and extrinsic factors (history of abuse, environment especially peers and family) which influence the progression from initial use to abuse., Many of these important differences emerge during adolescence, and are moderated by sexual differentiation of the brain. Estradiol effects which enhance both dopaminergic and CRF-mediated processes contribute to the female vulnerability to substance use and abuse. Testosterone enhances impulsivity and sensation seeking in both males and females. Several protective factors in females also influence initiation and progression of substance use including hormonal changes of pregnancy as well as greater capacity for self-regulation and lower peak levels of impulsivity/sensation seeking. Same sex peers represent a risk factor more for males than females during adolescence, while romantic partners increase risk for women during this developmental epoch. In summary, biologic factors, psychiatric co-morbidities as well as personality and environment present sex/gender-specific risks as adolescents begin to initiate substance use.

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“…Similar effects have recently been reported following treatment with allopregnanolone for both cocaine self-administration and for subsequent cocaine-seeking behavior (Anker & Carroll, 2010; Anker, Holtz, Zlebnik, & Carroll, 2009; Anker et al, 2007; Carroll & Anker, 2010). Further support for the idea that progesterone protects females is provided by results showing that during pregnancy, wherein progesterone levels progressively increase until a few days preceding birth, rats show a progressive decline in motivation for cocaine which rebounds in the few days preceding birth (Hecht, Spear, & Spear, 1999). …”

Section: Neurobiological Functions Of Progesteronementioning

confidence: 99%

Role of progesterone in nicotine addiction: Evidence from initiation to relapse.

Lynch

Sofuoglu

2010

Experimental and Clinical Psychopharmacology

139

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Nicotine addiction continues to be the main cause of preventable death in developed countries. Women and teen girls appear to be more vulnerable on certain aspects of nicotine addiction compared with men and boys. While the mechanism of gender differences in nicotine addiction is not yet clear, evidence suggests that while estrogen may underlie enhanced vulnerability in females, progesterone may protect females. Thus, progesterone may have therapeutic use for tobacco addiction, especially in female smokers. A greater understanding of the role of progesterone in nicotine addiction is important not only from a treatment standpoint, but also from a prevention standpoint: hormone transition phases, such as those that occur at adolescence, and during pregnancy and following birth, as well as following hormonal manipulation (e.g., using methods of hormonal birth control), may all contribute to changes in vulnerability to nicotine addiction. In this review, we summarize recent evidence from clinical and preclinical studies examining the role of progesterone in nicotine addiction focusing on its role during initiation of use and during later phases of the addiction process as a potential relapse prevention treatment. We conclude with future directions including further examination of progesterone as a potential intervention and treatment of nicotine addiction.

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Changes in progressive ratio responding for intravenous cocaine throughout the reproductive process in female rats

Cited by 82 publications

References 41 publications

Social Bonding Decreases the Rewarding Properties of Amphetamine through a Dopamine D1 Receptor-Mediated Mechanism

Social Bonding Decreases the Rewarding Properties of Amphetamine through a Dopamine D1 Receptor-Mediated Mechanism

Emergence of sex differences in the development of substance use and abuse during adolescence

Role of progesterone in nicotine addiction: Evidence from initiation to relapse.

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