Changes in Prevalence of Asthma and Allergies Among Children and Adolescents in Italy: 1994–2002

Galassi, Claudia; Sario, Manuela De; Biggeri, Annibale; Bisanti, Luigi; Chellini, Elisabetta; Ciccone, Giovannino; Petronio, Maria Grazia; Piffer, Silvano; Sestini, Piersante; Rusconi, Franca; Viegi, Giovanni; Forastiére, Francesco

doi:10.1542/peds.2004-2709

Cited by 156 publications

(148 citation statements)

References 23 publications

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“…Often, it is found that rhinitis prevalence increases faster than asthma prevalence, which was also found to decrease in some countries (904,947,948,1896,(1917)(1918)(1919)(1920)(1921)(1922). It appears that in regions of highest prevalence, the proportion of subjects suffering from asthma or rhinitis may be reaching a plateau (1919).…”

Section: Epidemiologic Links Between Rhinitis and Asthmamentioning

confidence: 99%

Allergic Rhinitis and its Impact on Asthma (ARIA) 2008*

Bousquet¹,

Khaltaev²,

Cruz³

et al. 2008

Allergy

3,754

1,761

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Section: Epidemiologic Links Between Rhinitis and Asthmamentioning

confidence: 99%

Allergic Rhinitis and its Impact on Asthma (ARIA) 2008*

Bousquet¹,

Khaltaev²,

Cruz³

et al. 2008

Allergy

3,754

1,761

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“…Vergleichbare Prävalenzen ärztlicher Allergiediagnosen hatten andere europäische Länder für 6-bis 7-Jährige verzeichnet, z. B. Spanien für Asthma bronchiale mit 6 % [12], Österreich für Asthma bronchiale mit 5 % und für Neurodermitis mit 14 % [13] sowie Italien für Heuschnupfen mit 9 % [14]. In der bislang größten internationalen Studie zu allergischen Erkrankungen bei Kindern und Jugendlichen, der International Study of Asthma and Allergy in Childhood (ISAAC), lag Deutschlandbezogen auf 13-bis 14-Jährige -bei der Häufigkeit von Symptomen innerhalb des letzten Jahres für Asthma bronchiale im oberen Drittel, für Heuschnupfen und Neurodermitis im Mittelfeld der untersuchten Länder [15].…”

unclassified

Verbreitung häufiger Allergien bei Kindern und Jugendlichen in Deutschland

Schmitz

Thamm

Ellert

et al. 2014

Bundesgesundheitsbl.

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“…Allergic rhinitis (AR) is a very common disease that affects up to 40% of children (1)(2)(3) and, particularly in moderate to severe cases, is associated with a significant reduction in the patients' quality of life, sleep disorders, emotional problems, and impaired school productivity and social functioning. Moreover, the chronic inflammatory process caused by AR favors the development of comorbidities, increases the incidence of ear problems such as acute otitis media (AOM) and otitis media with effusion (OME), and aggravates physiological adenoid and tonsil hypertrophy in the first years of life.…”

mentioning

confidence: 99%

Hypertonic Saline is More Effective Than Normal Saline in Seasonal Allergic Rhinitis in Children

Marchisio

Varricchio

Baggi

et al. 2012

Int J Immunopathol Pharmacol

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Allergic rhinitis (AR) is a very common childhood disease that is associated with a significant reduction in the patients' quality of life. Its treatment combines educating the patients and their parents, immunotherapy and drug administration. However, even the best approach does not relieve the symptoms of a number of patients. Alternative therapies are particularly needed for children because the fear of adverse events frequently reduces parental compliance to the prescribed drugs, and immunotherapy is less easy to administer than in adults. In this prospective investigator-blinded study we evaluated whether children, with a documented history of seasonal grass pollen-related AR, benefit from nasal irrigation by assessing the effects on nasal signs and symptoms, on middle ear effusion and on adenoidal hypertrophy. We randomized children aged 5 to 9 years (median age 82 months) to normal saline or hypertonic saline (a 2.7% sodium chloride solution), administered twice-daily using a disposable 20 ml syringe, or no treatment. Nasal symptoms (rhinorrhea, itching, sneezing, nasal obstruction), swelling of turbinates, adenoid hypertrophy or middle ear effusion were assessed at baseline and after 4 weeks of treatment. Two hundred and twenty children (normal saline: 80; hypertonic saline: 80; no treatment: 60) completed the study. After four weeks, all the considered items were significantly reduced in the group receiving hypertonic saline (P <0.0001), whereas in the group receiving normal saline only rhinorrhea (P = 0.0002) and sneezing (P = 0.002) were significantly reduced. There was no significant change in any of the items in the control group. The duration of oral antihistamines was significantly lower in the children receiving hypertonic saline than in those treated with normal saline or in controls. No adverse events were reported and parental satisfaction and compliance with the procedure were globally very good, regardless of the solution used. Using our procedure, hypertonic saline is effective, inexpensive, safe, well tolerated and easily accepted by children with seasonal grass pollen-related AR and their parents. Our data suggest that nasal irrigation with hypertonic saline might be included in the wide spectrum of therapies recommended for grass-pollen AR.

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Changes in Prevalence of Asthma and Allergies Among Children and Adolescents in Italy: 1994–2002

Abstract: The results indicate that the epidemiologic features of asthma and allergies in Italy are changing rapidly, although the causes are still uncertain.

Cited by 156 publications

References 23 publications

Allergic Rhinitis and its Impact on Asthma (ARIA) 2008*

Allergic Rhinitis and its Impact on Asthma (ARIA) 2008*

Verbreitung häufiger Allergien bei Kindern und Jugendlichen in Deutschland

Hypertonic Saline is More Effective Than Normal Saline in Seasonal Allergic Rhinitis in Children

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