Changes in Presentation of Celiac Disease in Ireland From the 1960s to 2015

Castro, Patricia Domínguez; Harkin, Grace; Hussey, Mary; Christopher, Brian; Kiat, Clifford; Chin, Jun Liong; Trimble, Valerie; McNamara, Deirdre; MacMathúna, Padraic; Egan, Brian; Ryan, Barbara; Kevans, David; Farrell, Richard J.; Byrnes, Valerie; Mahmud, Nasir; McManus, Ross

doi:10.1016/j.cgh.2016.11.018

Cited by 27 publications

(20 citation statements)

References 49 publications

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“…The increase was from 35 to 51 years in men and from 36 to 46 years in women. A similar increasing trend in the mean age at diagnosis has also been observed in recent decades in adult coeliac disease, both in Finland and elsewhere [ 28 , 29 , 30 ]. One explanation for this trend may be changes in dietary habits, such as the consumption of wheat, which in Sweden has changed the appearance of childhood coeliac disease [ 31 ].…”

Section: Gender and Age At Onsetsupporting

confidence: 73%

Dermatitis Herpetiformis: A Common Extraintestinal Manifestation of Coeliac Disease

et al. 2018

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Dermatitis herpetiformis (DH) is a common extraintestinal manifestation of coeliac disease presenting with itchy papules and vesicles on the elbows, knees, and buttocks. Overt gastrointestinal symptoms are rare. Diagnosis of DH is easily confirmed by immunofluorescence biopsy showing pathognomonic granular immunoglobulin A (IgA) deposits in the papillary dermis. A valid hypothesis for the immunopathogenesis of DH is that it starts from latent or manifest coeliac disease in the gut and evolves into an immune complex deposition of high avidity IgA epidermal transglutaminase (TG3) antibodies, together with the TG3 enzyme, in the papillary dermis. The mean age at DH diagnosis has increased significantly in recent decades and presently is 40–50 years. The DH to coeliac disease prevalence ratio is 1:8 in Finland and the United Kingdom (U.K.). The annual DH incidence rate, currently 2.7 per 100,000 in Finland and 0.8 per 100,000 in the U.K., is decreasing, whereas the reverse is true for coeliac disease. The long-term prognosis of DH patients on a gluten-free diet is excellent, with the mortality rate being even lower than for the general population.

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Section: Gender and Age At Onsetsupporting

confidence: 73%

Dermatitis Herpetiformis: A Common Extraintestinal Manifestation of Coeliac Disease

et al. 2018

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“…Initially, it was identified in up to 80% of the patients with CD, from which 1 out of 4 patients continues to present diarrheic stools after the start of a gluten-free diet, even if of lower severity (21). More recently, when less common CD clinical features were recognized or population CD screening was performed, the atypical presentation of CD was more frequently recognized, whereas a decrease in the prevalence of chronic diarrhea was noted (22).…”

Section: Cd: Celiac Diseasementioning

confidence: 99%

Physicians’ attitude and perception regarding celiac disease: A questionnaire-based study

Jinga

Popp

Balaban

et al. 2018

Turk J Gastroenterol

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“…Most studies in the literature have shown that CD patients (at diagnosis) have a lower BMI than the general population [10][11][12]; therefore, weight gain from a GFD may have positive effects on these patients. However, it has been clearly demonstrated that nowadays, an increasing number of CD patients present with a normal or high BMI at the time of diagnosis [3][4][5][6][7][8][9].…”

Section: Discussionmentioning

confidence: 99%

“…Historically, at the time of diagnosis, patents with CD had a reduced body mass index (BMI) compared to the general population [3]. In the last few decades, increasing numbers of CD patients with a normal or high BMI at the time of diagnosis was reported [4][5][6][7][8][9]. This could be due to the fact that early diagnosis has become more frequent in recent years (late diagnoses were more common in the past), allowing for a reduction in the rate of both intestinal mucosal atrophy and related malabsorption [9].…”

Section: Introductionmentioning

confidence: 99%

Celiac Disease, Gluten-Free Diet, and Metabolic and Liver Disorders

et al. 2020

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Celiac disease (CD) is a chronic autoimmune enteropathy triggered by the ingestion of gluten in genetically predisposed individuals. At the time of diagnosis, the frequency of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis in individuals with CD appears to be similar to that of the general population, although a lower body mass index and a lower rate of hypercholesterolemia and type 2 diabetes mellitus are observed at diagnosis in CD patients. The effect of a gluten-free diet (GFD) in individuals with these liver and metabolic disorders is still a matter of debate. The aim of this study was to investigate the links between a GFD and metabolic/liver disorders in CD patients. A systematic electronic search of the literature from January 2009 to December 2019 was performed using Medline, Web of Science, Scopus, and the Cochrane Library. Only papers written in English concerning metabolic and liver disorders in adult patients with CD were included. Out of 1195 citations, 14 eligible studies were identified. Increases in the frequency of NAFLD, weight gain, and alterations of the lipid profile suggest that important changes happen in celiac patients on a GFD, though the physiopathology of these conditions is unclear. Although a GFD is the only effective treatment available for CD, liver function, body weight, and metabolic and nutritional profiles should be monitored in patients on a GFD.

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Changes in Presentation of Celiac Disease in Ireland From the 1960s to 2015

Cited by 27 publications

References 49 publications

Dermatitis Herpetiformis: A Common Extraintestinal Manifestation of Coeliac Disease

Dermatitis Herpetiformis: A Common Extraintestinal Manifestation of Coeliac Disease

Physicians’ attitude and perception regarding celiac disease: A questionnaire-based study

Celiac Disease, Gluten-Free Diet, and Metabolic and Liver Disorders

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