Dermatitis Herpetiformis: A Common Extraintestinal Manifestation of Coeliac Disease

Reunala, Timo; Salmi, Teea; Hervonen, Kaisa; Kaukinen, Katri; Collin, Pekka

doi:10.3390/nu10050602

Cited by 75 publications

(84 citation statements)

References 64 publications

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“…Interestingly, other autoantibodies may also be involved, especially in extraintestinal manifestations, such as anti-ganglioside, anti-synapsin I and anti-actin antibodies [ 18 ]. Patients with CD present either typical or atypical symptoms [ 19 ] and CD is believed to perpetuate other maladies and often presents simultaneously with other autoimmune diseases [ 20 , 21 , 22 , 23 ]. Despite the great progress in CD research, new key emerging findings suggest previously unknown features of CD pathogenesis, for example at the transcriptome level of immune cells [ 24 ].…”

Section: Gluten-related Disorders and Celiac Diseasementioning

confidence: 99%

The Effect of Gluten-Free Diet on Health and the Gut Microbiota Cannot Be Extrapolated from One Population to Others

2018

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Gluten-related disorders (GRD) affect millions of people worldwide and have been related to the composition and metabolism of the gut microbiota. These disorders present differently in each patient and the only treatment available is a strict life-long gluten-free diet (GFD). Several studies have investigated the effect of a GFD on the gut microbiota of patients afflicted with GRD as well as healthy people. The purpose of this review is to persuade the biomedical community to think that, while useful, the results from the effect of GFD on health and the gut microbiota cannot be extrapolated from one population to others. This argument is primarily based on the highly individualized pattern of gut microbial composition and metabolic activity in each person, the variability of the gut microbiota over time and the plethora of factors associated with this variation. In addition, there is wide variation in the composition, economic viability, and possible deleterious effects to health among different GFD, both within and among countries. Overall, this paper encourages the conception of more collaborative efforts to study local populations in an effort to reach biologically and medically useful conclusions that truly contribute to improve health in patients afflicted with GRD.

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Section: Gluten-related Disorders and Celiac Diseasementioning

confidence: 99%

The Effect of Gluten-Free Diet on Health and the Gut Microbiota Cannot Be Extrapolated from One Population to Others

2018

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“…Long-term prognosis is excellent with consumption of a gluten-free diet, although clinical response is slow and most patients require dapsone initially to control rash-related symptoms. 39 Iodine ingestion may cause flares of the disease and should be discouraged.…”

Section: Clinical Featuresmentioning

confidence: 99%

Celiac Disease

Oxentenko

Rubio–Tapia

2019

Mayo Clinic Proceedings

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“…Recent studies have shown that the incidence of dermatitis herpetiformis is decreasing in contrast to CD, which is increasing. 120 Arthralgia and non-erosive arthritis can be seen in children with CD, although is not generally appreciated in clinical practice. The incidence is reported to be around 5-10%, with knee joint being the most commonly affected, followed by hip and ankle joints.…”

Section: Groups At Increased Genetic Risk Of Coeliac Diseasementioning

confidence: 99%

Coeliac disease in childhood: An overview

Bishop

Ravikumara

2020

J Paediatrics Child Health

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Coeliac disease (CD) is an autoimmune condition, characterised by an immunological response to ingestion of gluten in genetically susceptible individuals, affecting about 1% of the population in many regions of the world. Increased knowledge regarding the pathogenesis, improved diagnostic techniques and increased awareness over the years have transformed our understanding of CD such that it is no longer a rare enteropathy, but rather a common multisystem disorder which affects individuals of all ages and results in wide‐ranging clinical manifestations. Only a minority of children now present with the classical clinical picture of profound diarrhoea and malnutrition. An increasing number of children with CD present with either mild, non‐specific gastrointestinal symptoms or extra‐intestinal manifestations or even be asymptomatic, as in many screening‐detected children. Knowledge about these diverse manifestations and a high index of suspicion is essential so that appropriate investigations can be undertaken, diagnosis established and treatment initiated. Although traditionally small bowel biopsy is considered essential for the diagnosis, recent guidelines from various professional bodies have paved the way to a biopsy‐free diagnosis in a subset of symptomatic children. Life long, strict gluten‐free diet still remains the only effective treatment at present, although several novel therapeutic agents are in various phases of clinical trials.

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Dermatitis Herpetiformis: A Common Extraintestinal Manifestation of Coeliac Disease

Cited by 75 publications

References 64 publications

The Effect of Gluten-Free Diet on Health and the Gut Microbiota Cannot Be Extrapolated from One Population to Others

The Effect of Gluten-Free Diet on Health and the Gut Microbiota Cannot Be Extrapolated from One Population to Others

Celiac Disease

Coeliac disease in childhood: An overview

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