Changes in platelet function, volume and count during labor and 24 hours postpartum

Abstract

Increased platelet activation has been reported during labor. We evaluated changes in platelet count, volume and function during labor and 24 hours postpartum. Platelet function during labor was not previously evaluated. Twenty-five healthy women in labor, subsequently having singleton spontaneous vaginal delivery following uncomplicated pregnancy at term were recruited for this prospective study. Blood was withdrawn during latent phase, active phase, second stage of labor, and 24 hours postpartum. Platelet function was assessed by hemoSTATUS2 test (Hepcon, Medtronic, USA). Twenty-five healthy non-pregnant volunteers served as controls. Platelet count and volume did not change significantly throughout labor and 24 hours postpartum. Platelet function was 120.8 +/- 26.9 %, 106.8 +/- 24.6 % (p = 0.06), 105.2 +/- 30.9 % (p < 0.05), and 117.6 +/- 21.5 % during latent phase, active phase, second stage of labor, and 24 hours postpartum, respectively. Platelet function was altered during labor while platelet count and volume did not change significantly. Platelet function remained increased when compared to non-pregnant controls.

Is there any relation between intrauterine growth restriction and platelet distribution width (PDW), platelet crit (PCT), mean platelet volume (MPV)? A prospective study

“…Akingbola et al reported that decreament in PDW values during pregnancy is an expected situation [21]. In contrast to this study, Lurie et al showed that platelet activation values such as PDW are higher in pregnant women than that of non-pregnant women (22). Karateke et al investigated PDW values in preeclamptic patients and they reported that PDW values were higher than normal pregnant women [11].…”

Antithrombotische Therapie in der Schwangerschaft

“…B. durch abnehmende Protein-S-Aktivität [7]. Die Thrombozytenzahl nimmt während der Schwangerschaft und peripartal ab, um wenige Tage nach der Geburt zusammen mit der Plättchenaggregabilität anzusteigen [10]. Hinzu treten in den spä- bis 4-6 h vor der Entbindung (I, C) Zu beachten ist zudem, dass wöchentliche Kontrollen der Antikoagulation während der gesamten Schwangerschaft erforderlich sind und die Dosen der VKA und der Heparine entsprechend angepasst werden müssen (aPTT ≥ 2-Fache der Norm, bei NMH: Ziel-Anti-Xa-Spiegel 4-6 h nach Gabe 0,8-1,2 U/ml).…”