Changes in plasma volume, in transcapillary escape rate of albumin and in subcutaneous blood flow during hypoglycaemia in man

Abstract

Hypoglycaemia was induced by insulin injected intravenously (0.15 i.u./kg body weight) in seven healthy young males. Plasma volume was measured before and during hypoglycaemia by intravenous injection of 125I before hypoglycaemia and of 131I during hypoglycaemia. Plasma volume decreased and transcapillary escape rate increased significantly during hypoglycaemia. Skin temperature and local subcutaneous adipose tissue blood flow were measured in four different regions. Both tended to decrease during hypoglycaemia and decreased significantly 2 h after hypoglycaemia. There was no correlation between changes in the two measurements, suggesting that there is no simple relationship between subcutaneous blood flow and skin temperature during hypoglycaemia.

The Continuous Glucose Monitoring System During Pregnancy of Women with Type 1 Diabetes Mellitus: Accuracy Assessment

“…13 Furthermore, additional effects due to alterations in subcutaneous blood flow during hypoglycemia cannot be ruled out, although an increase and a decrease during hypoglycaemia have both been described. [15][16][17][18] Finally, it may also be argued that, because of measurement errors, home fingerstick capillary blood glucose levels are not always representative for plasma blood glucose levels. [19][20][21] Several reports have cast doubt on the accuracy of home monitoring devices in pregnant women with diabetes with glucose levels ranging up to 8.0 mmol/L.…”

Vascular disease and diabetes: is hypoglycaemia an aggravating factor?

“…Erythrocytes Experimental studies of acute hypoglycaemia have demonstrated a modest increase in the number of circulating erythrocytes in relation to the peak of plasma epinephrine concentration in response to the hypoglycaemic stimulus [80,81]. This apparent erythrocytosis is probably a manifestation of haemo-concentration and a rise in packed cell volume rather than the entry of red blood cells into the circulation from storage sites, as this response is preserved in people who have undergone previous splenectomy [82].…”

Glucagon‐like peptide‐1 elicits vasodilation in adipose tissue and skeletal muscle in healthy men

“…In a study by Hilsted et al. (), a decrease in subcutaneous ATBF was found during hypoglycemia (~2 mmol/L), induced by insulin injected intravenously. This vasoconstriction was probably due to stimulation of vascular α ‐receptors by increased circulating catecholamines.…”

“…Altogether, indicating that a significant activation of the sympathetic nervous system was probably not induced in this study by the transient decrease in blood glucose levels induced by GLP-1. In a study by Hilsted et al (1985), a decrease in subcutaneous ATBF was found during hypoglycemia (~2 mmol/L), induced by insulin injected intravenously. This vasoconstriction was probably due to stimulation of vascular a-receptors by increased circulating catecholamines.…”