Glucagon‐like peptide‐1 elicits vasodilation in adipose tissue and skeletal muscle in healthy men

Abstract

In healthy subjects, we recently demonstrated that during acute administration of GLP‐1, cardiac output increased significantly, whereas renal blood flow remained constant. We therefore hypothesize that GLP‐1 induces vasodilation in other organs, for example, adipose tissue, skeletal muscle, and/or splanchnic tissues. Nine healthy men were examined twice in random order during a 2‐hour infusion of either GLP‐1 (1.5 pmol kg−1 min−1) or saline. Cardiac output was continuously estimated noninvasively concomitantly with measurement of intra‐arterial blood pressure. Subcutaneous, abdominal adipose tissue blood flow (ATBF) was measured by the 133Xenon clearance technique. Leg and splanchnic blood flow were measured by Fick's Principle, using indocyanine green as indicator. In the GLP‐1 study, cardiac output increased significantly together with a significant increase in arterial pulse pressure and heart rate compared with the saline study. Subcutaneous, abdominal ATBF and leg blood flow increased significantly during the GLP‐1 infusion compared with saline, whereas splanchnic blood flow response did not differ between the studies. We conclude that in healthy subjects, GLP‐1 increases cardiac output acutely due to a GLP‐1‐induced vasodilation in adipose tissue and skeletal muscle together with an increase in cardiac work.

Co-ingestion of whey protein hydrolysate with milk minerals rich in calcium potently stimulates glucagon-like peptide-1 secretion: an RCT in healthy adults

“…Regarding the second possibility, GLP-1 concentrations are higher in arterial, compared to venous blood [34,35], presumably due to tissue uptake or binding with GLP-1 receptors. Therefore, as with glycaemia [22], it may be recommended to sample from arterial or arterialized blood when systemic postprandial gut hormone concentrations require accurate quantification.…”

Effects of Acute GLP-1 Infusion on Pulmonary and Systemic Hemodynamics in Patients With Heart Failure: A Pilot Study

“…One explanation may be that differential tissue blood flow occurs after GLP-1 infusion. 20 Redistribution of blood through a more metabolically active, higheoxygenextracting tissue with a relatively small percentage of total cardiac output (4%e5%) (eg, the heart), could reduce mixed oxygen saturation while having minimal effect on global cardiac output. Augmentation of coronary blood flow after GLP-1 could mitigate postischemic stunning and LV dysfunction by this mechanism, via the Gregg effect.…”

Venous blood provides lower glucagon‐like peptide‐1 concentrations than arterialized blood in the postprandial but not the fasted state: Consequences of sampling methods

“…Moreover, if differences between venous and arterialized blood are not consistent, then comparisons between studies using different blood sampling methods would be problematic. Indeed, blood sampling methods for GLP-1 measurement commonly vary between studies, with samples from capillary, arterial, arterialized or venous blood (Asmar et al, 2017;Gonzalez et al, 2015;Green, Gonzalez, Thomas, Stevenson, & Rumbold, 2014), albeit arterial blood is much less frequently sampled owing to the greater technical challenge.…”

“…Moreover, if differences between venous and arterialized blood are not consistent, then comparisons between studies using different blood sampling methods would be problematic. Indeed, blood sampling methods for GLP‐1 measurement commonly vary between studies, with samples from capillary, arterial, arterialized or venous blood (Asmar et al., ; Gonzalez & Stevenson, ; Gonzalez et al., ; Green, Gonzalez, Thomas, Stevenson, & Rumbold, ), albeit arterial blood is much less frequently sampled owing to the greater technical challenge. However, to date, no study has ever examined whether postprandial GLP‐1 concentrations differ in venous compared with arterialized blood, and thus whether the method of blood sampling has implications for determining the relationship between GLP‐1 and insulinemia (i.e.…”