Changes in plasma lipoproteins in acute malaria

Abstract

Plasma lipid and lipoprotein concentrations were monitored in 16 patients with acute malaria. Plasma high density lipoprotein (HDL) levels decreased dramatically during the first 3 d after diagnosis to around 0.2 mmol l-1 (reference range 0.8-1.6 mmol l-1). The low HDL levels were related to parasitaemia, and rapidly recovered after successful therapy. Plasma triglyceride concentrations were moderately increased and plasma low density lipoprotein (LDL) cholesterol concentrations decreased during the course of infection. The mechanisms underlying the selective and pronounced decline in HDL cholesterol concentration remain obscure, but the reproducible phenomenon may be useful as an additional diagnostic tool in suspected malaria infection.

Serum Lipoproteins Promote Efficient Presentation of the Malaria Virulence Protein PfEMP1 at the Erythrocyte Surface

“…A number of studies have reported an altered lipid composition in lipoproteins from patients with P. falciparum infections (3,21,44,45,59). However, the extent and nature of the changes differ between different studies, and it is difficult to predict the effects of these changes on the efficiency of presentation of PfEMP1 in infected RBCs in vivo.…”

Effect of Severity Disease on the Pharmacokinetics of Cefuroxime in Children with Multiple Organ System Failure

“…Analytical Method Concentrations of CXM in plasma were determined by a modified high pressure liquid chromatography method (HPLC) previously described by Nilsson-Ehle I, 12) which modifies the ratio of the mobile phase consisting of acetic acid/water/methanol (1 : 69 : 30 by vol). To 0.5 ml of plasma, 1 ml of dimethylformamide was added and then the mixture stirred rapidly on a vortex-type mixer before being heated for 1 min in a water bath set at 60°C.…”

Malaria parasitemia and its association with lipid and hematological parameters among malaria-infected patients attending at Metema Hospital, Northwest Ethiopia

“…This finding is in contrast to data reported in other studies that showed elevated levels of lipoproteins in patients suffering from malaria infection. [37][38][39][40] On the contrary, a study reported that hyperlipidemia is one of the indicators of malaria infection; the hypothesis for the changes is basically due to increased VLDL production and increased mobilization of free fatty acids from adipose tissue in response to stress. 41 However, the evidence of higher concentrations of serum lipids in the infected group might be due to adipose tissue lipolysis, impairment in lipoprotein lipase system, increases in de novo hepatic fatty acid synthesis, and suppression of fatty acid oxidation in severe infection.…”