Changes in plasma concentrations of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D during pregnancy: a Brazilian cohort

Figueiredo, Amanda Faria de; Cocate, Paula Guedes; Adegboye, Amanda Rodrigues Amorim; Franco‐Sena, Ana Beatriz; Farias, Dayana Rodrigues; Castro, Maria Beatriz Trindade de; Brito, Alex; Allen, Lindsay H.; Mokhtar, Rana; Holick, Michael F.; Kac, Gilberto

doi:10.1007/s00394-017-1389-z

Cited by 31 publications

(36 citation statements)

References 59 publications

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“…A high prevalence of vitamin D insufficiency according to the ESPG was previously reported in this cohort (47) , which is similar to results found for pregnant women in other studies using this threshold (48,49) . Schneuer et al (48) observed that 80•4 % of 5109 pregnant women from Australia had vitamin D insufficiency in the first trimester.…”

supporting

confidence: 91%

Longitudinal association of 25-hydroxyvitamin D with adipokines and markers of glucose metabolism among Brazilian pregnant women

Benaim

Cocate

Barros³

et al. 2018

Br J Nutr

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This study aimed to evaluate the longitudinal association of vitamin D status with glycaemia, insulin, homoeostatic model assessment of insulin resistance, adiponectin and leptin. A prospective cohort with 181 healthy, pregnant Brazilian women was followed at the 5th–13th, 20th–26th and 30th–36th gestational weeks. In this cohort, 25-hydroxyvitamin D (25(OH)D) plasma concentrations were analysed using liquid chromatography–tandem MS. Vitamin D status was categorised as sufficient or insufficient using the Endocrine Society Practice Guidelines (≥75/<75 nmol/l) and the Institute of Medicine (≥50/<50 nmol/l) thresholds. Linear mixed-effect regression models were employed to evaluate the association between vitamin D status and each outcome, considering interaction terms between vitamin D status and gestational age (P<0·1). At baseline, 70·7 % of pregnant women had 25(OH)D levels <75 nmol/l and 16 % had levels <50 nmol/l. Women with sufficient vitamin D status at baseline, using both thresholds, presented lower glycaemia than those with insufficient 25(OH)D. Pregnant women with 25(OH)D concentrations <75 nmol/l showed lower insulin (β=−0·12; 95 % CI −0·251, 0·009;P=0·069) and adiponectin (β=−0·070; 95 % CI −0·150, 0·010;P=0·085) concentrations throughout pregnancy than those with 25(OH)D levels ≥75 nmol/l. Pregnant women with 25(OH)D <50 nmol/l at baseline presented significantly higher leptin concentrations than those with 25(OH)D levels ≥50 nmol/l (β=−0·253; 95 % CI −0·044, 0·550;P=0·095). The baseline status of vitamin D influences the biomarkers involved in glucose metabolism. Vitamin D-sufficient women at baseline had higher increases in insulin and adiponectin changes throughout gestation than those who were insufficient.

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supporting

confidence: 91%

Longitudinal association of 25-hydroxyvitamin D with adipokines and markers of glucose metabolism among Brazilian pregnant women

Benaim

Cocate

Barros³

et al. 2018

Br J Nutr

Self Cite

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“…In Brazilian pregnant women, the more common complications are hypertensive disorders and infections (urinary tract infection and vaginosis) [22]. The related nutritional condition has an association between overweight/obesity and micronutrient deficiency, especially for iron and vitamins A and D [23, 24]. Infant feeding practices are different too.…”

Section: Discussionmentioning

confidence: 99%

Body Mass Index and Cardiovascular Risk Factors in Children and Adolescents with High Birth Weight

et al. 2018

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Background/Aims: This study aimed to identify a possible association among high birth weight with overweight/obesity, high arterial blood pressure, dyslipidemia, and insulin resistance in children and adolescents. Methods: This is a cross-sectional study with 719 children and adolescents (6–12 years) stratified according to birth weight (low birth weight [LBW] <2,500 g, adequate birth weight [ABW] 2,500–3,999 g, and high birth weight [HBW] ≥4,000 g). Data collected were anthropometric data, arterial blood pressure levels, lipid profile, and insulin resistance (fasting glucose and insulin, used to calculate homeostatic model assessment-IR). Results: The mean age of schoolchildren was 9.5 ± 2.0 years and 371 (51.6%) were male. LBW and HBW were observed in 79 of 719 (10.9%) and 40 of 719 (55.6%) children/adolescents, respectively. There was no increased risk of overweight (OR 0.9; 95% CI 0.4–2.1; p = 0.964) and obesity (OR 1.4; 95% CI 0.6–3.5; p = 0.588) in HBW group compared to LBW and ABW groups. HBW was not associated with high blood pressure, dyslipidemia, and insulin resistance. The LBW group was independently associated with higher values of systolic (OR 1.07; 95% CI 1.05–1.10; p < 0.01) and diastolic blood pressure (OR 1.04; 95% CI 1.00–1.07; p = 0.044). Conclusion: There was no association between HBW with overweight/obesity and classic cardiovascular risk factors in this group of children/adolescents. Only LBW was related to higher blood pressure levels.

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“…Multivariate linear regression analyses of the association between 25-hydroxyvitamin D 3 (25(OH)D 3 ) concentration (nmol/l) and gestational age at birth in weeks among a random sample of infants born at term (weeks[37][38][39][40][41][42][43][44] in the years between 1981 and 2002 in Denmark (n 2686)* (Coefficients with their standard errors and 95 % confidence intervals)…”

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confidence: 99%

Concentration of 25-hydroxyvitamin D from neonatal dried blood spots and the relation to gestational age, birth weight and Ponderal Index: the D-tect study

et al. 2018

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Studies have suggested that vitamin D status at birth may be associated with a range of neonatal outcomes. The aim of this study was to assess the association between neonatal 25-hydroxyvitamin D3 (25(OH)D3) concentration and gestational age, birth weight, Ponderal Index and size for gestational age. Neonatal capillary blood stored as dried blood spots was used to assess 25(OH)D3 concentrations among 2686 subjects selected from a random population sub-sample of individuals, born in Denmark from 1 May 1981 to 31 December 2002. There was an inverse association between 25(OH)D3 concentration and gestational age at birth of -0·006 (95 % CI -0·009, -0·003, P<0·001) weeks of gestation per 1 nmol/l increase in 25(OH)D3 concentration. An inverted U-shaped association between 25(OH)D3 and birth weight and Ponderal Index (P=0·04) was found, but no association with size for gestational age was shown. This study suggests that neonatal 25(OH)D3 concentration is associated with anthropometric measures at birth known to be correlated with many subsequent health outcomes such as obesity and type 2 diabetes.

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Changes in plasma concentrations of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D during pregnancy: a Brazilian cohort

Cited by 31 publications

References 59 publications

Longitudinal association of 25-hydroxyvitamin D with adipokines and markers of glucose metabolism among Brazilian pregnant women

Longitudinal association of 25-hydroxyvitamin D with adipokines and markers of glucose metabolism among Brazilian pregnant women

Body Mass Index and Cardiovascular Risk Factors in Children and Adolescents with High Birth Weight

Concentration of 25-hydroxyvitamin D from neonatal dried blood spots and the relation to gestational age, birth weight and Ponderal Index: the D-tect study

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