Changes in Plasma Concentration Of Serotonin In Response To Spinal Stabilisation Exercises In Chronic Low Back Pain Patient

A Randomized Controlled Trial (Rct) on the Effects of Frequency Of Application Of Spinal Stabilisation Exercises On Plasma Serotonin Levels In Participants With Chronic Low Back Pain

“…A model of stabilization exercise programme presented in this study began with audio visual information related to the spine and how the spine and local stability muscles work together to protect the spine was provided to aid mental imagery of correct performance prior to carrying out proper stabilization exercise protocol. Stabilization exercise protocols used in this study were similar to the one used in the previously reported studies 2,3,5 Control Group Participants allocated to the control group received no exercise treatment during the time the study was carried out.…”

“…It is generally accepted that serotonin is involved in the mechanism of exercises induced analgesia 4 . Recent preliminary studies suggested an increase in the plasma level of serotonin produced with the use of stabilization exercises as one of the main facilitation techniques behind the efficacy of stabilization exercises 3,5 . However the question of what is an appropriate dosage of treatment that can be expected to achieve a desired outcome in terms of plasma serotonin levels were not addressed in Sokunbi et al's studies 3,5 .…”

“…Recent preliminary studies suggested an increase in the plasma level of serotonin produced with the use of stabilization exercises as one of the main facilitation techniques behind the efficacy of stabilization exercises 3,5 . However the question of what is an appropriate dosage of treatment that can be expected to achieve a desired outcome in terms of plasma serotonin levels were not addressed in Sokunbi et al's studies 3,5 . Also, there is dearth need for a large randomized controlled trials with more participants with low back pain in order to make the study more generalizable to population of patients that suffer with low back pain.…”

“…Sample size estimation for the present RCT was based on the results of our preliminary study 5 whereby participants showed at least 18% increase in plasma serotonin level in response to a similar exercises. To yield a power of 80% with a significant level of 0.05, a sample size of at least 15 subjects in each group was required (sample size estimation was determined by power analysis sample size software).…”

“…The blood was then centrifuged at 1600xg for 15 minutes. Extraction of peptides and assaying for the level of plasma serotonin was carried out according to the instruction of the manufacturer and in a similar way as described by Sokunbi et al 3,5 . After the initial blood taking participants in the exercise groups were asked to rest for another 5 minutes to observe for any changes in the cardiovascular parameters prior to commencing any further physical activities.…”