2018
DOI: 10.1016/j.jmpt.2018.01.002
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Immediate Effects of Core Stabilization Exercise on β-Endorphin and Cortisol Levels Among Patients With Chronic Nonspecific Low Back Pain: A Randomized Crossover Design

Abstract: The findings of this study indicate that LCSE could possibly influence PB but not PC level among patients with chronic nonspecific low back pain. The mechanism of action of the pain-relieving effect of LCSE might be related to an endogenous opioid mechanism as part of its effects and might not be involved with a stress-induced analgesia mechanism.

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Cited by 33 publications
(31 citation statements)
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“…Furthermore, the core exercise alone group also demonstrated a reduction in pain, PPT, and LBP-related disability. Indeed, several studies that investigated the effect of core exercise on pain and sensory and motor function support our results [19,31,32]. Core exercise may influence the β-endorphin level in patients with chronic nonspecific LBP, and the mechanism of action of the pain-relieving effect of core exercise might be related to an endogenous opioid mechanism [32].…”
Section: Discussionsupporting
confidence: 82%
“…Furthermore, the core exercise alone group also demonstrated a reduction in pain, PPT, and LBP-related disability. Indeed, several studies that investigated the effect of core exercise on pain and sensory and motor function support our results [19,31,32]. Core exercise may influence the β-endorphin level in patients with chronic nonspecific LBP, and the mechanism of action of the pain-relieving effect of core exercise might be related to an endogenous opioid mechanism [32].…”
Section: Discussionsupporting
confidence: 82%
“…10 Thus, high intensity or duration of exercise may lead with the release of beta-endorphins, producing changes in pain sensitivity. 29,30 This explanation could also partially justify our results that indicated a reduction in bodily, lumbar and sciatic pain, and pain disability, with higher overall PF during pregnancy. These results could also be explained through increasing tissue oxygenation as a result of aerobic physical activity that may diminish peripheral and central sensitization, thus reducing pain intensity.…”
Section: Discussionsupporting
confidence: 58%
“…The exact mechanisms to explain hypoalgesia are still unclear, although one of them is the activation of the endogenous opioid system . Thus, high intensity or duration of exercise may lead with the release of beta‐endorphins, producing changes in pain sensitivity . This explanation could also partially justify our results that indicated a reduction in bodily, lumbar and sciatic pain, and pain disability, with higher overall PF during pregnancy.…”
Section: Discussionmentioning
confidence: 71%
“…( 25 ) In addition, LPST was reported to cause a significant release of plasma endorphin that resulted in pain reduction among participants with CLBP. ( 26 ) Therefore, it is possible that a combination therapy of massage with LPST may produce pain modulation as a therapeutic benefit through pain gate theory and endogenous opioids-induced analgesic effects in low back pain.…”
Section: Discussionmentioning
confidence: 99%