Changes in Oxygen Consumption of Kidney during Maturation

Caldwell, T.; Solomon, Sidney

doi:10.1159/000240673

Cited by 7 publications

(3 citation statements)

References 18 publications

(26 reference statements)

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“…This difference could be due to the increase in aerobic metabolism of kidney tissue found in the rat between the age of 30 and 60 days (Caldwell & Solomon, 1975;Capek, Drahota, Jelinek & Kunei, 1976) and is also manifested by the increase of renal cytochrome oxidase activity found at this time.…”

Section: Discussionmentioning

confidence: 94%

Age-Dependent Difference of Kidney Response to Temporary Ischaemia in the Rat

et al. 1978

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1. The response to 60 min ischaemia was studied in male uninephrectomized 30-, 60-and 90day-old rats in regard to changes of renal cytochrome oxidase activity and the effect on systemic arterial blood pressure. Mortality due to renal failure, changes in plasma urea concentration and in kidney morphology were used as indicators of the renal response.2. Mortality was lowest in 30-day-old animals (13%) and highest in 60-day-old animals (77%). Renal cytochrome oxidase activity increased by 44% during the same period. The mortality decreased to 34% between the ages of 60 and 90 days without change in renal content of cytochrome oxidase; survival time after renal ischaemia was prolonged from 2 to 4 days.3. Fifty days after renal ischaemia plasma urea concentration correlated positively with kidney weight. Both variables were increased in rats exposed to ischaemia at the ages of 60 and 90 days. The kidneys of these rats exhibited lesions. No relation was found between the degree of renal damage and blood pressure. 4. It is concluded that (a) the kidney of immature rats is more resistant to temporary ischaemia due to immaturity of renal oxidative metabolism, (b) the ability to survive ischaemic renal damage in less-resistant mature rats increases with age and (c) the postischaemk impairment of renal function does not influence systemic arterial blood pressure.

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Section: Discussionmentioning

confidence: 94%

Age-Dependent Difference of Kidney Response to Temporary Ischaemia in the Rat

et al. 1978

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“…Other groups of workers also found no or only small differences in oxygen consump tion of slices in dependence on age [9,10,29,30]. In contrast, anaerobic glycolysis is better developed in newborn rat kidney cortex and medulla [10].…”

Section: Discussionmentioning

confidence: 94%

“…In general, kid neys from adult animals have been investi gated. In the newborn kidney only oxygen consumption, anaerobic glycolysis and gluconeogenesis have been studied [3,9,10,29].…”

Section: Introductionmentioning

confidence: 99%

Some Aspects of Renal Energy and Lipid Metabolism in Newborn Rats

Hohenegger¹,

Brezina²

1984

Neonatology

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Some aspects of renal energy and lipid metabolism were studied in the postnatal period of rats. Oxygen consumption, RQ values, stimulation of oxygen consumption by exogenous substrates (8 mM glucose, 8 mM acetate, 1 mM palmitate), and conversion of acetate or palmitate to CO₂ were measured in slices of cortex and inner medulla. The results obtained in 5-day-old rats are not essentially different from those observed in adults. On the other hand, the phenomenon of triacylglycerol storage in kidney cortex during starvation (well known in adult animals) is absent in the newborn rat. It can be demonstrated first in 30-day-old rats. At the same age renal arteriovenous concentration differences for total glycerol indicate a significant uptake during starvation and a release in the fed state.

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The Kidney During Development

Spitzer

Schwartz

1992

Comprehensive Physiology

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The sections in this article are: Historical Perspective Standards of Reference for Comparison of Renal Function Between Infants and Adults Morphogenesis of the Kidney Embryologic Origin of the Kidney Subsequent Development of the Kidney Glomerulus Renal Tubule Renal Blood Flow and its Control During Development Total Renal Blood Flow Intrarenal Distribution of Blood Flow Renal Microvasculature Control of Renal Circulation Glomerular Filtration Net Ultrafiltration Pressure Hydraulic Conductivity and Ultrafiltration Coefficient Glomerular Capillary Surface Area Factors That Affect GFR during Development Autoregulation of GFR Renal Energy Metabolism Development of Renal Cortical Metabolic Pathways Tubular Functions Renal Reabsorption of Sodium Reabsorption of Bicarbonate and Excretion of Hydrogen Ions Glucose Transport Transport of Amino Acids Transport of Organic Acids Phosphate Transport Control of Renal Transport during Development Calcium Transport Magnesium Transport Potassium Transport Concentration of Urine Developmental Renal Physiology as A Tool for Understanding the Emergence and Integration of Renal Transport Systems

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Changes in Oxygen Consumption of Kidney during Maturation

Cited by 7 publications

References 18 publications

Age-Dependent Difference of Kidney Response to Temporary Ischaemia in the Rat

Age-Dependent Difference of Kidney Response to Temporary Ischaemia in the Rat

Some Aspects of Renal Energy and Lipid Metabolism in Newborn Rats

The Kidney During Development

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