Changes in oxidative stress indices, zinc and copper concentrations in blood in canine demodicosis

Dimri, Umesh; Ranjan, Rakesh; Kumar, Nishant; Sharma, Mahesh; Swarup, D.; Sharma, Bhaskar; Kataria, Meena

doi:10.1016/j.vetpar.2008.03.001

Cited by 46 publications

(38 citation statements)

References 19 publications

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“…Increase in SOD activity might be attributed to up-regulation in its synthesis to counteract free radicals. The increase in SOD level in the present study was in agreement with the findings of Sathya et al (2007) in dystocia affected buffalo and Dimri et al (2008a) in canine demodicosis. On day 0, the erythrocytes' CAT level was significantly (P B0.05) lower in all the dogs with HQW as compared to the healthy control.…”

Section: Resultssupporting

confidence: 92%

“…MDA assay has been found to be one of the better predictors of oxidative damage and often shows excellent correlation with other markers, such as isoprostanes, which are considered to be the most reliable markers of LPO (Morrow 2000). Similar findings of increased levels of LPO were reported in various disorders like inflammation (Lykkesfeldt 2002), canine demodicosis (Dimri et al 2008a), caprine scabies (De and Dey 2010), sarcoptes in dogs (Camkerten et al 2009), buffalo (Dimri et al 2008b) and camel (Saleh et al 2011). After treatment began, a continuous significant (P B0.05) decrease in LPO in all of the treated groups suggested a decrease in excess free radicals.…”

Section: Resultsmentioning

confidence: 61%

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Effect of therapeutic ultrasound and diathermy on oxidant–antioxidant balance in dogs suffering from hind quarter weakness

Zama

Ansari

Dimri

et al. 2013

Journal of Applied Animal Research

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The present study was conducted to evaluate the erythrocytic oxidantÁantioxidant balance in dogs suffering from hind quarter weakness (HQW) and treated with conventional drug therapy (CDT, n 08) alone and in combination with therapeutic ultrasound (US, n 08) and shortwave diathermy (SWD, n 08). A further eight healthy dogs were used as controls. For oxidant level, Lipid Peroxidation (LPO) and antioxidant levels Reduced Glutathione (GSH), Superoxide Dismutase (SOD) and Catalase (CAT) were evaluated in erythrocyte before (day 0) and after 3, 7, 14 and 28 days of therapy. In dogs with HQW, LPO in terms of Malondialdehyde (MDA) production, was found significantly (P B0.05) increased compared to a healthy control on day 0. Thereafter, a significant (PB0.05) decrease in the level of LPO was noticed. Amongst antioxidant enzymes, activities of GSH and CAT decreased significantly (PB0.05) whereas, the level of SOD increased significantly (PB0.05) until day 28 post treatment. Studies revealed that SWD and therapeutic ultrasound in conjunction with CDT can be used to counter free radical-mediated oxidative cell injury, induced by HQW in dogs. However, SWD proved to be better in minimizing excess free radicals production and activating antioxidant defense system as compared to therapeutic ultrasound.

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Section: Resultssupporting

confidence: 92%

Section: Resultsmentioning

confidence: 61%

Effect of therapeutic ultrasound and diathermy on oxidant–antioxidant balance in dogs suffering from hind quarter weakness

Zama

Ansari

Dimri

et al. 2013

Journal of Applied Animal Research

View full text Add to dashboard Cite

show abstract

“…Recent ones include selamectin (Schnabl et al, 2010). Also use of amitraz collars, closantel, deltamethrin, vitamin and Se, PUFAs (Behera et al, 2011;Singh et al, 2011), herbal and homeopathic preparations (Dimri et al, 2008), muramyl dipeptide and phoxime has been recommended in skin affections (Mueller, 2004;Gorte, 2006).…”

Section: Discussionmentioning

confidence: 99%

Advances in Therapeutic Management of Complicated Demodicosis in Canines

Yatoo¹

2014

J. adv. parasitol.

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“…According to authors who observed decreased levels of endogenous antioxidants (e.g., glutathione peroxidase, CAT, copper, and zinc) in dogs with localized and generalized demodicosis, the disease is related to the occurrence of oxidative stress, suggesting supplementation with antioxidants as part of the diet (DIMRI et al, 2008). In another study, the presence of oxidative stress in the eyeball of dogs with cataracts after phacoemulsification was compared between a group with intraocular lens implant and a group without lens implant.…”

Section: Biomarkers Of Oxidative Stressmentioning

confidence: 99%

Oxidative stress in dogs

Russo

Bracarense

2016

SCA

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Reactive oxygen species (ROS), also known as free radicals, are generated during cellular respiration. Under normal conditions, the body has the ability to neutralize the effects of free radicals by using its antioxidant defenses. In the case of an imbalance between oxidants and antioxidants, free radical production exceeds the capacity of organic combustion, resulting in oxidative stress. Of all the cellular components compromised by the harmful effects of ROS, the cell membrane is the most severely affected owing to lipid peroxidation, which invariably leads to changes in the membrane structure and permeability. With lipid peroxidation of the cell membrane, some by-products can be detected and measured in tissues, blood, and other bodily fluids. The measurement of biomarkers of oxidative stress is commonly used to quantify lipid peroxidation of the cell membrane in humans, a species in which ROS can be considered as a cause or consequence of oxidative stress-related diseases. In dogs, few studies have demonstrated this correlation. The present review aims to identify current literature knowledge relating to oxidative stress diseases and their detection in dogs. Key words: Oxidative stress. Lipid peroxidation. Free radicals. Dogs. ResumoNos processos decorrentes da respiração celular, são gerados produtos denominados espécimes reativos de oxigênio (EROS), conhecidos também como radicais livres. Em condições normais, o organismo possui capacidade de neutralizar os efeitos dos radicais livres utilizando suas defesas antioxidantes. Em situações de desequilíbrio entre agentes oxidantes e antioxidantes, a produção de radicais livres excede a capacidade orgânica de neutralização, resultando na condição conhecida como estresse oxidativo. Dentre todos os componentes celulares atingidos pelos efeitos nocivos dos EROS, as membranas celulares são as estruturas mais severamente acometidas, devido à peroxidação lipídica, que leva, invariavelmente, a alterações estruturais e também na sua permeabilidade. Na peroxidação lipídica da membrana celular, alguns subprodutos podem ser detectados e mensurados nos tecidos, sangue e outros fluidos corpóreos. A mensuração de biomarcadores de estresse oxidativo é habitualmente utilizada para quantificar a lipoperoxidação da membrana celular em humanos, espécie onde as EROS podem ser consideradas como causa ou consequência de doenças relacionadas ao estresse oxidativo. Nos cães, alguns poucos estudos demonstram essa correlação. A presente revisão tem como principal objetivo verificar na literatura, onde se encontra atualmente o conhecimento relacionando o estresse oxidativo às doenças em cães bem como as possíveis formas de detecção de biomarcadores na espécie canina. Palavras-chave: Estresse oxidativo. Lipoperoxidação. Radicais livres. Cães.

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Changes in oxidative stress indices, zinc and copper concentrations in blood in canine demodicosis

Cited by 46 publications

References 19 publications

Effect of therapeutic ultrasound and diathermy on oxidant–antioxidant balance in dogs suffering from hind quarter weakness

Effect of therapeutic ultrasound and diathermy on oxidant–antioxidant balance in dogs suffering from hind quarter weakness

Advances in Therapeutic Management of Complicated Demodicosis in Canines

Oxidative stress in dogs

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