Changes in Oxidative Stress Biomarker and Gene Expression Levels in Workers Exposed to Volatile Organic Compounds

Assessment of Oxidative Stress and Antioxidant Status Among Petrol Stations’ Workers Exposed to Benzene in Zagazig City

“…These findings are in agreement with other studies (6,24) that observed significant correlation between the concentration of benzene in the blood and elevated levels of MDA, also these studies showed that the level of SOD was significantly decreased in the study group exposed to benzene compared to controls. Kim et al (29) also found significant association between the level of MDA and biomarkers for Benzene, toluene, ethylbenzene, and xylene (BTEX).…”

Dysregulation of markers of oxidative stress and DNA damage among nail technicians despite low exposure to volatile organic compounds

“…While interpreting these outcomes, it seems reasonable to assume that increased activities of antioxidant enzymes might be indicative of increased oxidative stress, possibly caused by an occupational exposure of nail technicians. Indeed, exacerbation of oxidative stress has already been implicated in mechanisms underlying the effects exerted by the low-level exposure to VOC in both the animal models (22,45) and human subjects (10,11,46). Notwithstanding, the above-mentioned lack of any significant changes in levels of TBARS and DNA strand breaks between nail technicians and control subjects seems to contradict this thesis.…”

“…Nevertheless, interest in the oxidative damage caused by these solvents' toxic effects have only is relatively new, and thus the amount of evidence concerning their possible genotoxic and carcinogenic potential is scarce and still under discussion. Even though these substances are considered to be neither carcinogenic nor genotoxic to humans (IARC class 3 carcinogens, ie, not classifiable as to their carcinogenicity to humans), there is a growing amount of evidence suggesting increased (i) levels of markers of oxidative stress (10)(11)(12), (ii) rate of chromosomal aberrations or sister chromatid exchange (12)(13)(14), and (iii) incidence of various cancers among workers occupationally exposed to toluene or xylene [even at occupational exposures far below the respective occupational limits (15)(16)(17)(18)(19)(20)(21)]. Although precise mechanisms underlying the effects of toluene and xylene remain unknown, the role of oxidative stress, oxidative DNA damage and dysregulated cellular antioxidant levels have been implicated (22)(23)(24).…”

Cocaine effects on generation of reactive oxygen species and DNA damage: formation of 8-hydroxydeoxyguanosine in active abusers

“…(Ece et al (2012)) and chronic hepatitis (Nishida et al (2013)) suggesting that a variety of diseases are characterized by an increased levels of oxidative damage of DNA. In the occupational exposure studies the increase of 8-OHdG was related to volatile organic compounds exposure (Kim et al (2011)), in foundry workers (Lin et al (2011)), in male electrical and electronic equipment dismantling workers exposed to high concentrations of polychlorinated dibenzo-p-dioxins and dibenzofurans, polybrominated diphenyl ethers, and polychlorinated biphenyls (Wen et al (2008)). A positive association between ROS and levels of 8-OHdG has been found in lifestyle changing such as alcohol, tobacco, and morphine exposure (Zhang et al (2004)).…”