Spatial modes of light can potentially carry a vast amount of information, making them promising candidates for both classical and quantum communication. However, the distribution of such modes over large distances remains difficult. Intermodal coupling complicates their use with common fibers, whereas free-space transmission is thought to be strongly influenced by atmospheric turbulence. Here, we show the transmission of orbital angular momentum modes of light over a distance of 143 km between two Canary Islands, which is 50× greater than the maximum distance achieved previously. As a demonstration of the transmission quality, we use superpositions of these modes to encode a short message. At the receiver, an artificial neural network is used for distinguishing between the different twisted light superpositions. The algorithm is able to identify different mode superpositions with an accuracy of more than 80% up to the third mode order and decode the transmitted message with an error rate of 8.33%. Using our data, we estimate that the distribution of orbital angular momentum entanglement over more than 100 km of free space is feasible. Moreover, the quality of our free-space link can be further improved by the use of state-of-the-art adaptive optics systems.high-dimensional states | long-distance communication | orbital angular momentum | atmospheric turbulence T he transverse spatial modes of light offer an additional degree of freedom for encoding information in both classical and quantum communication. In classical communication, such modes can be used for multiplexing information and for increasing the achievable data rate per frequency and polarization channel (1-4); for recent reviews, see refs. 5 and 6. In quantum information science they are a physical realization of a high-dimensional quantum state (7-12). Such states allow one to encode more than 1 bit of information per photon. The large state space can increase the channel capacity and improve robustness to eavesdropping and noise (13,14) in quantum communication schemes (15)(16)(17)(18). The distribution of photons carrying different spatial modes over macroscopic distances is thus essential for both quantum and classical applications, as well as for fundamental tests of quantum mechanics. Whereas significant progress has been made in fiber-based solutions (19,20), these methods are still in their infancy. Here we focus on a different way to distribute such modes, namely long-distance transmission through free space. This is relevant in situations where fibers are not applicable, such as for long-distance quantum communication and communication with satellites.Atmospheric turbulence plays a significant role in the freespace transmission of spatial modes. These effects of the atmosphere have been investigated in many recent theoretical studies (21-27) and laboratory-scale simulations (28-33). Although these investigations clearly show that transmitting spatial modes of light over large distances is very challenging, recently several experimental inve...