Changes in non-oscillatory features of the cortical sensorimotor rhythm in Parkinson's disease across age

Abstract

Parkinson's disease (PD) is associated with changes in neural activity in the sensorimotor alpha and beta bands. Using magnetoencephalography (MEG), we investigated the role of spontaneous neuronal activity within the somatosensory cortex in a large cohort of early- to mid-stage PD patients (N = 78) and age- and sex matched healthy controls (N = 60) using source reconstructed resting-state MEG. We quantified features of the time series data in terms of oscillatory alpha power, beta power, and 1/f broadband characteristics using power spectral density, and also characterised transient beta burst events in the time-domain signals. We examined the relationship between these signal features and the patients’ disease state, symptom severity, age, sex, and cortical thickness.PD patients and healthy controls differed on PSD broadband characteristics, with PD patients showing a steeper 1/f exponential slope and higher 1/f offset. PD patients further showed a steeper age-related decrease in the burst rate. Out of all the signal features of the sensorimotor activity, only burst rate was associated with increased severity of bradykinesia. Our study shows that general non-oscillatory features (broadband PSD slope and offset) of the sensorimotor signals are related to disease state and oscillatory burst rate scales with symptom severity in PD.

Fractal cycles of sleep: a new aperiodic activity-based definition of sleep cycles

“…As opposed to the oscillatory component, the fractal component is usually treated as a unity and, therefore, is filtered in the broadband frequency range (Donoghue et al, 2020; Bódizs et al, 2021; Gerster et al, 2022). Nevertheless, different studies defined (slightly) differing bands, e.g., 30 – 50Hz (Gao et al, 2017; Lendner et al, 2020), 3 – 55Hz (Waschke et al, 2021), 0.5 – 35Hz (Miskovic et al, 2019), 1 – 40Hz, 1 – 20Hz and 20 – 40Hz (Colombo et al, 2019), 1 – 45Hz (Helson et al, 2023), 0.5 – 40Hz (Vinding et al, 2023), 3 – 45Hz and 30 – 45Hz (Höhn et al, 2022) and 2 – 48Hz (Bódizs et al, 2021; Schneider et al, 2022).…”

Resting EEG Periodic and Aperiodic Components Predict Cognitive Decline Over 10 Years

“…However, many disease stages, such as Parkinson's Disease, are characterized by an excess of inhibitory activity, and previous studies have emphasized that excessive inhibitory activity reduces behavioral flexibility (Song et al, 2021;Vinding et al, 2022;McKeown et al, 2023). These results hint at the importance of considering excitatory:inhibitory balance within an individual differences context, as what is optimal may differ based on a variety of neuroanatomical and physiological parameters.…”