Changes in non-fasting concentrations of blood lipids after a daily Chinese breakfast in overweight subjects without fasting hypertriglyceridemia

Tian, Feng; Xiang, Qunyan; Zhang, Mingyu; Chen, Yanqiao; Lin, Qiuzhen; Wen, Tie; Liu, Ling

doi:10.1016/j.cca.2019.01.004

Cited by 26 publications

(28 citation statements)

References 41 publications

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“…Recently, we observed more substantial reductions in LDL-C and non-HDL-C levels in Chinese subjects with CHD at 2 h and 4 h after a daily breakfast [13,16], appearing to be greater than those reported in large-scale clinical studies conducted in other countries [14,15,17,18],although the potential cause remains uncertain. Additionally, it was proposed that non-HDL-C level may be a better prognostic factor than LDL-C level to evaluate the risk of future cardiovascular events [19][20][21][22][23][24].…”

Section: Introductionmentioning

confidence: 66%

“…Indeed, it was found that the percent attainment of postprandial LDL-C or/and non-HDL-C was significantly higher than that of fasting values in the present study, suggesting that the fasting goals of LDL-C < 1.8 mmol/L and non-HDL-C < 2.6 mmol/L were indeed unsuitable for the evaluation of postprandial cholesterol control. ROC analysis has been used to identify the optimal cut-off point for the diagnosis of postprandial hypertriglyceridemia [16,28,29] but not for determining goals of LDL-C and non-HDL-C in the non-fasting state corresponding to the fasting goals. Because the non-fasting cut-off points acquired by ROC analysis corresponded to the fasting goals of LDL-C < 1.8 mmol/L and non-HDL-C < 2.6 mmol/L, the postprandial percent attainments were very similar to their respective fasting values.…”

Section: Discussionmentioning

confidence: 99%

“…Third, the diet structures of Chinese and western people are very different. For example, the Chinese people prefer carbohydrates[16]. It is not clear whether the high-carbohydrate diet will cause a more significant decline in cholesterol.…”

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confidence: 99%

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Optimal cut-off points after a daily meal corresponding to fasting goal levels of LDL-C and non-HDL-C in Chinese patients with coronary heart disease

Guo

Chen

Lin

et al. 2020

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Background: Although the detection of non-fasting blood lipids has been recommended in patients with coronary heart disease (CHD), the non-fasting cut-off points corresponding to the fasting goals of LDL-C < 1.8 mmol/Land non-HDL-C < 2.6 mmol/L, respectively, have not been explored. Methods: This study enrolled 397 inpatients with CHD. One hundred and ninety-seven patients took statins for < 1 month (m) or did not take any statin before admission (i.e. CHD1 group), while 204 patients took statins for ≥ 1 m before admission (i.e. CHD2 group). Blood lipid levels were measured at 0 h, 2 h, and 4 h after a daily breakfast. Results: Non-fasting low-density lipoprotein cholesterol (LDL-C) and non-high-density lipoprotein cholesterol (non-HDL-C) levels significantly decreased after a daily meal ( P < 0.05). Both fasting and non-fasting LDL-C or non-HDL-C levels were significantly lower in the CHD2 group. The percent attainment of LDL-C < 1.8 mmol/L at 2 h or 4 h after a daily breakfast was significantly higher than that of its fasting point ( P < 0.05), whereas that of non-HDL-C < 2.6 mmol/L was significantly higher only at 4 h ( P < 0.05). Analysis of c-statistic showed that non-fasting cut-off points for LDL-C and non-HDL-C were 1.5 mmol/L and 2.4 mmol/L, corresponding to their fasting goal levels of 1.8 mmol/L and 2.6 mmol/L, respectively. When postprandial LDL-C and non-HDL-C goal attainments were re-evaluated by non-fasting cut-off points, there were no significant differences in percent attainment between fasting and non-fasting states. Conclusions: Determination ofnon-fasting cut-off points is important to evaluate the efficacy of cholesterol-lowering therapy if blood lipids are detected after a daily meal.

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Section: Introductionmentioning

confidence: 66%

Section: Discussionmentioning

confidence: 99%

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Optimal cut-off points after a daily meal corresponding to fasting goal levels of LDL-C and non-HDL-C in Chinese patients with coronary heart disease

Guo

Chen

Lin

et al. 2020

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“…There is a drop in some nonfasting cholesterol parameters after a daily meal [10]. The maximal mean reduction in LDL-C or non-HDL-C 1-6 h after habitual food intake was only 0.2 mmol/L, which was considered insigni cant in a population from Copenhagen [11].…”

Section: Introductionmentioning

confidence: 92%

Comparison of the Reductions in LDL-C and Non-HDL-C Induced by the Red Yeast Rice Extract Xuezhikang Between Fasting and Nonfasting States in Patients With Coronary Heart Disease

Zhu

Wen

Xiang

et al. 2020

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Background: Xuezhikang, an extract of red yeast rice, effectively lowers fasting blood lipid levels. However, the influence of Xuezhikang on nonfasting levels of low-density lipoprotein cholesterol (LDL-C) and non-high-density lipoprotein cholesterol (non-HDL-C) has not been explored in Chinese patients with coronary heart disease (CHD).Methods: Fifty CHD patients were enrolled and randomly divided into two groups (each n = 25) to receive 1200 mg/d Xuezhikang or not for six weeks as routine therapy. Blood lipids were measured repeatedly before and after six weeks of treatment at 0, 2, 4 and 6 hours (h) after a standard breakfast containing 800 kcal and 50 g fat.Result: Serum LDL-C levels significantly decreased, from a fasting level of 3.88 mmol/L to nonfasting levels of 2.99, 2.83 and 3.23 mmol/L at 2, 4 and 6 h, respectively, after breakfast (P<0.05), while there was no significant difference in total cholesterol (TC) levels between the fasting value and the values at any nonfasting time-points. The serum non-HDL-C level mildly increased from a fasting level of 4.29 mmol/L to nonfasting levels of 4.32, 4.38 and 4.34 mmol/L at 2, 4 and 6 h postprandially, respectively, and the difference reached statistical significance only at 4 and 6 h after breakfast (P < 0.05). There was no difference in fasting and nonfasting blood lipids between the two groups at baseline. After six weeks of Xuezhikang treatment, patients had significantly lower fasting and nonfasting serum levels of LDL-C and HDL-C (P < 0.05) than they did pretreatment. LDL-C levels were reduced by 27.8%, 28.1%, 26.2% and 25.3% at 0, 2, 4 and 6 h, respectively, and non-HDL-C levels were reduced by 27.6%, 28.7%, 29.0% and 28.0% at 0, 2, 4 and 6 h, respectively, after breakfast. There was no significant difference in the percent reductions in LDL-C and non-HDL-C levels among the four different time-points.Conclusions: A six-week Xuezhikang (1200 mg/d) treatment significantly decreased LDL-C and non-HDL-C levels, with similar percent reductions in fasting and nonfasting states in CHD patients. This may indicate that nonfasting blood lipids detected at the same time point after a standard meal could replace fasting blood lipids when evaluating the efficacy of cholesterol control in CHD patients who are unwilling or unable to fast.

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“…As we know that study about evaluating cardiovascular risk with non-fasting blood lipids for primary prevention in China is rare [21], especially about the comparison of fasting and non-fasting blood lipids in the same patients within a same day [22]. Furthermore, there was no study to compare the roles of two different risk assessment tools in risk strati cation in Chinese general subjects via fasting or non-fasting blood lipids after a daily meal in a same day.…”

Section: Introductionmentioning

confidence: 99%

Fasting and non-fasting lipid profile for cardiovascular risk assessments using China ASCVD risk estimator and Europe SCORE risk charts in Chinese participants

Zhang

et al. 2020

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Background Previous studies have shown that non-fasting lipids have similar values in cardiovascular risk estimation as fasting, but it is not clear whether this could also be applicable to Chinese participants.Methods A total of 127 (76 men, 51 women) participants without atherosclerotic cardiovascular diseases (ASCVD) were enrolled in the study. Serum levels of blood lipids were monitored at 0 h, 2 h and 4 h after a daily breakfast. Ten-year cardiovascular disease (CVD) risk was estimated with China ASCVD risk estimator and Europe SCORE risk charts. Kappa statistic was used to determine agreement among estimators.Results there was substantial agreement between China ASCVD risk estimator based on fasting and non-fasting lipid profiles (Kappa = 0.731 or 0.718, P < 0.001), but poorly agreement between China ASCVD risk estimator and SCORE low- or high-risk chart (Kappa = 0.339 or 0.300, P < 0.001).Conclusions Promoting use of non-fasting blood lipids in diagnosis, evaluation, and prediction of CVD are feasible. Furthermore, non-fasting blood lipids could be used in China ASCVD risk estimator to evaluate assess 10-year risk of ASCVD among Chinese general participants.

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Changes in non-fasting concentrations of blood lipids after a daily Chinese breakfast in overweight subjects without fasting hypertriglyceridemia

Cited by 26 publications

References 41 publications

Optimal cut-off points after a daily meal corresponding to fasting goal levels of LDL-C and non-HDL-C in Chinese patients with coronary heart disease

Optimal cut-off points after a daily meal corresponding to fasting goal levels of LDL-C and non-HDL-C in Chinese patients with coronary heart disease

Comparison of the Reductions in LDL-C and Non-HDL-C Induced by the Red Yeast Rice Extract Xuezhikang Between Fasting and Nonfasting States in Patients With Coronary Heart Disease

Fasting and non-fasting lipid profile for cardiovascular risk assessments using China ASCVD risk estimator and Europe SCORE risk charts in Chinese participants

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