Changes in nitric oxide production in the rat kidney due to CaOx nephrolithiasis

Huang, Huey W.; Chieh, Ming; Chen, Chau Fong

doi:10.1002/nau.20152

Cited by 16 publications

(23 citation statements)

References 19 publications

(27 reference statements)

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“…These findings indicate that rats supplemented with spirulina for the last three weeks were mostly recovered from nephrolithiasis and completely from hepatotoxicity induced by ethylene glycol at the first three weeks. Nephrolithiasis and hepatotoxicity induction by ethylene glycol was established in many researches (Christina et al, 2002;Atmani et al, 2003;Huang et al, 2006;Karadi et al, 2006;Celik and Suzek, 2007;Hadjzadeh et al, 2007;Hadjzadeh et al, 2008;Verma et al, 2009;Divaka et al, 2010). The mechanism underlying the effect of spirulina on nephrolithiasis induced by ethylene glycol is still unknown, but is apparently related to increased diuresis and lowering of urinary concentrations of stone forming constituents.…”

Section: Discussionmentioning

confidence: 99%

Antilithiatic Influence of Spirulina on Ethylene Glycol-Induced Nephrolithiasis in Male Rats

Al-Attar¹

2010

American Journal of Biochemistry and Biotechnology

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Problem statement: Nephrolithiasis or renal stone disease remains a significant health problem in the adult population. Nephrolithiasis is a recurrent disorder prominent in males. It is significant medical and surgical problem because of incidence, recurrence and severe consequences. The present day medical management of nephrolithiasis is either costly or not without side effects. Invasive procedures for the treatment of nephrolithiasis may cause serious complications and they also impose a great load of costs to the healthcare system. Hence the search for antilithiatic drugs from natural sources has assumed greater importance. Approach: The aim of the present study was to evaluate the antilithiatic activity of spirulina supplementation on ethylene glycol induced nephrolithiasis in male rats. Healthy male Wistar rats were used in the present study and were divided randomly into 4 groups. Rats of 1st group were served as normal control. Rats of 2nd group were received 0.75% ethylene glycol in drinking water for three weeks and drinking tap water for the next three weeks. Rats of 3rd group were received 0.75% ethylene glycol in drinking water for three weeks and fed with spirulina solution (20 mg kg −1 body weight) for the next three weeks. Animals of 4th group were treated as 1st group for the first three weeks and fed with spirulina solution ate the same dose given to 3rd group for the last three weeks. After six weeks, serum levels of sodium, chloride, potassium, calcium, phosphorus, Blood Urea Nitrogen (BUN), uric acid, creatinine, Alanine aminotransferase (ALT), Aspartate aminotransferase (AST) were measured. Results: Statistically increases in the levels of sodium, chloride, BUN and ALT and a decrease in the level of calcium were noted in rats treated with ethylene glycol. Supplementation of spirulina for the last three weeks mostly recovered the rats from nephrolithiasis and completely from hepatotoxicity induced by ethylene glycol. Conclusion:This study suggested that spirulina is a safety and promising agent as a functional food for the management of nephrolithiasis induced by ethylene glycol and may be also by other chemical factors.

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Section: Discussionmentioning

confidence: 99%

Antilithiatic Influence of Spirulina on Ethylene Glycol-Induced Nephrolithiasis in Male Rats

Al-Attar¹

2010

American Journal of Biochemistry and Biotechnology

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“…The activity of lactate dehydrogenase (LDH) was determined using a commercial kit (Roche, Tokyo, Japan) as described previously (Bucciarelli et al, 2006). Stable metabolites of NO in the coronary effluent, such as nitrite and nitrate, were examined using a commercial kit according to the manufacturer's instructions (Cayman, Ann Arbor, MI, USA), as described previously (Huang et al, 2006). Quantitative immunoassays were performed to determine the intra-cardiac level of EPO (Biomerica, Newport Beach, CA) in accordance with the manufacturer's protocol.…”

Section: Biochemical Assaysmentioning

confidence: 99%

Erythropoietin alleviates post-ischemic injury of rat hearts by attenuating nitrosative stress

Lu¹,

Chen

Huang

et al. 2012

Life Sciences

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“…In fact, a few markers of chronic inflammation and oxidative stress have been detected in patients with renal stones at early stage (6)(7)(8). In addition, markers of oxidative and nitrosative stress such as enzymes involved in lipid peroxidation, peroxynitrite and 3-nitrotyrosine (3NT), have all been detected in the rat kidney due to nephrolithiasis (9,10). Khan (7) has also pointed out from his study that inflammation from renal injury plays a significant role in stone formation, and the stone crystal will further lead to the development of oxidative stress.…”

Section: Introductionmentioning

confidence: 99%

Multiple risk markers for atherogenesis associated with chronic inflammation are detectable in patients with renal stones

Tsao

Sun

et al. 2007

Clinical Laboratory Analysis

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Patients with renal stones are known to be at risk of clinical complications such as cardiovascular disease (CVD), nephropathy, and cancer. Recently, it has been realized that almost all risk markers for CVD, nephropathy, etc. are all markers associated with the sequence of reactions of chronic inflammation. It has been reported that chronic inflammation is involved not only in the pathogenesis of nephrolithiasis but also contributes to the development of clinical complications in this condition; therefore, we decided to find out whether these multiple markers are detectable in patients with renal stones so that they can be used to predict the risk of clinical complications in these patients. There were 33 patients with nephrolithiasis included in this study. We found that almost all major markers of chronic inflammation were elevated in patients with renal stones, including proinflammatory cytokine, acute inflammation markers, adhesion molecules, urinary microalbumin (uMA), myeloperoxidase (MPO), 8-hydroxydeoxyguanosine (8-OHdG), 3-nitrotyrosine (3NT), and monocyte chemoattractant protein. It appears that it is possible to assess the risk of clinical complications by monitoring these markers in patients with renal stones.

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Changes in nitric oxide production in the rat kidney due to CaOx nephrolithiasis

Cited by 16 publications

References 19 publications

Antilithiatic Influence of Spirulina on Ethylene Glycol-Induced Nephrolithiasis in Male Rats

Antilithiatic Influence of Spirulina on Ethylene Glycol-Induced Nephrolithiasis in Male Rats

Erythropoietin alleviates post-ischemic injury of rat hearts by attenuating nitrosative stress

Multiple risk markers for atherogenesis associated with chronic inflammation are detectable in patients with renal stones

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