Changes in nitric oxide metabolism in co-morbidity of chronic obstructive pulmonary disease and chronic cerebral ischemia

Abstract

Changes in nitric oxide metabolism in co morbidity of chronic obstructive pulmonary disease and chronic cerebral ischemia SummaryThe study was aimed at investigation of nitric oxide (NO) metabolism including total and separate concentrations of stable NO metabolites (nitrate anions and nitrite anions) and 3 nitrotirosine concentration in stable chronic obstructive pulmonary disease (COPD) and in COPD with concomi tant chronic cerebral ischemia (CCI). The study involved 55 patients aged 51 to 67 years divided into 2 groups: 28 patients with COPD II-III stage (the 1 st group) and 27 patients with COPD II-III stage and concomitant CCI II-III stage (the 2 nd group). The control group included 25 healthy non smoking volunteers. A significant increase in nitrate anion concentration and in the total nitrite and nitrate concentration was found in the blood of patients of both groups compared to the controls. A statistically significant inverse relationship was found between the blood nitrite anion concentration and FEV1 (r = -0.77; p < 0.05) in COPD patients. These results demonstrate that changes in NO metabolism related to nitrous stress could emerge even in stable COPD. In co existing COPD and CCI, changes in these biomarkers could be also related to functional particularities of nitrite reductase apart from the nitrous stress.

Scientific research of the Federal Pulmonology Research Institute and its role for improvement of respiratory care quality in Russia

“…При ХОБЛ и сочетании ХОБЛ с хронической ишемией головного мозга в сравнении с контролем выявлено достоверное увеличение содержания в кро ви как нитрат анионов, так и Σ NO2 -/ NO3 - [82]. При исследовании содержания нитрит анионов за регистрировано их достоверное повышение только при ХОБЛ в сравнении с группой контроля.…”

“…Полученные данные свидетель ствуют о том, что даже в стадии ремиссии при ХОБЛ наблюдаются изменения метаболизма NO, отражаю щие развитие нитрозивного стресса. При сочетании ХОБЛ с хронической ишемией головного мозга изменения исследованных показателей, помимо нитрозивного стресса, очевидно, связаны с особен ностями функционирования нитрит редуктазных систем [82].…”

The State of the Nitric Oxide Cycle in Respiratory Tract Diseases

“…Therefore, we have proposed an extension of the concept of a nitric oxide cycle. It includes the NO-synthase and NO-synthase-independent component of its synthesis and the accompanying redox cascade, in varying degrees of reversible reactions [ 26 – 28 ] ( Figure 1 ).…”

The functional status of neutrophils in patients with bronchial asthma, chronic obstructive pulmonary disease, bronchial asthma with chronic obstructive pulmonary disease, and community-acquired pneumonia

“…22 Active oxygen forms can irrevocably damage DNA, RNA, proteins, and lipids, which leads to biomembrane damage and dysfunction, and the destruction of various cells and tissues. 23 Oxidant and antioxidant imbalance in patients with COPD creates oxidative stress, which is one of the pathogenetic mechanisms of COPD. 24 The respiratory burst produced by alveolar macrophages may be reduced in patients with BA, which worsens the phagocytic activity of macrophages, disrupts antimicrobial defense, 25 leads to airway hypersensitivity and increased bronchial smooth muscle contractility, and increases mucus secretion.…”