Changes in nitric oxide level and superoxide dismutase activity during antimanic treatment

Gergerlioğlu, H. Serdar; Savaş, Haluk A.; Bülbül, Feridun; Selek, Salih; Uz, Efkan; Yumru, Mehmet

doi:10.1016/j.pnpbp.2006.12.020

Cited by 101 publications

(73 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although the current state of evidence is not yet mature enough to adopt this in clinical practice, findings of syndrome- (Reddy et al, 2003) and phase-specific profiles, and treatment-related normalization (Bilici et al, 2001;Dakhale et al, 2004;Frey et al, 2007;Gergerlioglu et al, 2007;Henneman and Altschule, 1951;Herken et al, 2007;Khanzode et al, 2003;Ozcan et al, 2004;Zhang et al, 2003) support this as a possible future application. Genetic polymorphisms of antioxidant enzymes, associated with psychiatric disorders (Akyol et al, 2005;Saadat et al, 2007;Tosic et al, 2006), may have potential in assisting the identification of at-risk individuals.…”

Section: Discussionmentioning

confidence: 99%

“…Indirect support for the pathophysiological role of oxidative stress in bipolar disorder comes from clinical studies that demonstrate normalisation of oxidative parameters over the course of treatment (Frey et al, 2007;Gergerlioglu et al, 2007;Henneman and Altschule, 1951;Ozcan et al, 2004). This has been elegantly illustrated by a case report of twins presenting with mania, where increased TBARS, SOD and DNA damage, and decreased CAT were observed in both patients prior to treatment.…”

Section: Clinical Studiesmentioning

confidence: 99%

See 1 more Smart Citation

Oxidative stress in psychiatric disorders: evidence base and therapeutic implications

Berk

Dean

et al. 2008

Int. J. Neuropsychopharm.

865

569

View full text Add to dashboard Cite

Oxidative stress has been implicated in the pathogenesis of diverse disease states, and may be a common pathogenic mechanism underlying many major psychiatric disorders, as the brain has comparatively greater vulnerability to oxidative damage. This review aims to examine the current evidence for the role of oxidative stress in psychiatric disorders, and its academic and clinical implications. A literature search was conducted using the Medline, Pubmed, PsycINFO, CINAHL PLUS, BIOSIS Previews, and Cochrane databases, with a time-frame extending to September 2007. The broadest data for oxidative stress mechanisms have been derived from studies conducted in schizophrenia, where evidence is available from different areas of oxidative research, including oxidative marker assays, psychopharmacology studies, and clinical trials of antioxidants. For bipolar disorder and depression, a solid foundation for oxidative stress hypotheses has been provided by biochemical, genetic, pharmacological, preclinical therapeutic studies and one clinical trial. Oxidative pathophysiology in anxiety disorders is strongly supported by animal models, and also by human biochemical data. Pilot studies have suggested efficacy of N-acetylcysteine in cocaine dependence, while early evidence is accumulating for oxidative mechanisms in autism and attention deficit hyperactivity disorder. In conclusion, multi-dimensional data support the role of oxidative stress in diverse psychiatric disorders. These data not only suggest that oxidative mechanisms may form unifying common pathogenic pathways in psychiatric disorders, but also introduce new targets for the development of therapeutic interventions.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Clinical Studiesmentioning

confidence: 99%

Oxidative stress in psychiatric disorders: evidence base and therapeutic implications

Berk

Dean

et al. 2008

Int. J. Neuropsychopharm.

865

569

View full text Add to dashboard Cite

show abstract

“…125 In addition, in several prospective studies, reductions in oxidative stress markers corresponded with improvement in psychiatric symptoms. [126][127][128][129] Levels of thiobarbituric acid reactive substances and nitric oxide activity may be especially increased in patients with BD. 119,129 Taken together, findings from these studies lend support to the hypothesis that oxidative damage may be involved in the pathophysiology of MDD and BD among adults.…”

Section: Oxidative Stressmentioning

confidence: 99%

Major Depressive Disorder and Bipolar Disorder Predispose Youth to Accelerated Atherosclerosis and Early Cardiovascular Disease

Goldstein¹,

Carnethon²,

Matthews³

et al. 2015

Circulation

404

290

View full text Add to dashboard Cite

Abstract-In the 2011 "Expert Panel on Integrated Guidelines for Cardiovascular Health and Risk Reduction in Children andAdolescents," several medical conditions among youth were identified that predispose to accelerated atherosclerosis and early cardiovascular disease (CVD), and risk stratification and management strategies for youth with these conditions were elaborated. Major depressive disorder (MDD) and bipolar disorder (BD) among youth satisfy the criteria set for, and therefore merit inclusion among, Expert Panel tier II moderate-risk conditions. The combined prevalence of MDD and BD among adolescents in the United States is ≈10%, at least 10 times greater than the prevalence of the existing moderate-risk conditions combined. The high prevalence of MDD and BD underscores the importance of positioning these diseases alongside other pediatric diseases previously identified as moderate risk for CVD. The overall objective of this statement is to increase awareness and recognition of MDD and BD among youth as moderate-risk conditions for early CVD. To achieve this objective, the primary specific aims of this statement are to (1) summarize evidence that MDD and BD are tier II moderate-risk conditions associated with accelerated atherosclerosis and early CVD and (2)

show abstract

“…These studies have found a disruption of the oxidative balance in psychiatric disorders. It was reported that this imbalance is sustained in some psychiatric disorders even during remission while some studies reported recovery in oxidative imbalance after treatment [2,[12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Oxidative metabolism may be associated with negative symptoms in schizophrenia

Güneş

Altındağ

Bulut

et al. 2017

Psychiatry and Clinical Psychopharmacology

View full text Add to dashboard Cite

Objective: In the present study, we aimed to examine the relationship between the oxidative metabolism with disease severity, sociodemographic, and clinical characteristics in the patients with schizophrenia. Methods: Seventy-one patients with schizophrenia and 76 healthy volunteers were included in the study. Plasma total antioxidant level (TAL) and total oxidant level (TOL) were analyzed, and oxidative stress index (OSI) was calculated.Results: There was a statistically significant increase in TOL and OSI and decrease in TAL in the patients with schizophrenia compared to the controls (p < .05). There were positive, mild, statistically significant correlations between TOL, OSI, and Positive and Negative Syndrome Scale-Total scores (p = .01, p = .01, respectively), Positive and Negative Syndrome ScaleNegative scores (p = .002, p = .001, respectively), Positive and Negative Syndrome Scale Global Psychopathology scores (p = .03, p = .03, respectively), and Clinical Global ImpressionSeverity Scale scores (p = .008, p = .009 respectively). OSI levels were significantly lower in the patients who were on treatment with atypical antipsychotics (AAP) compared to the patients who were on typical antipsychotics (TAP) and combined antipsychotic (CAP) agents (p = .032). Conclusions: Oxidative stress was higher in schizophrenia patients. The increased severity of negative symptoms was in line with the disruption in oxidative balance. Oxidative stress is quite lower in AAP users compared to the TAP and CAP users. One of the mechanisms underlying the fact that AAPs are more effective on negative symptoms than typical agents may be the positive effect on the oxidative stress.ARTICLE HISTORY

show abstract

Changes in nitric oxide level and superoxide dismutase activity during antimanic treatment

Cited by 101 publications

References 49 publications

Oxidative stress in psychiatric disorders: evidence base and therapeutic implications

Oxidative stress in psychiatric disorders: evidence base and therapeutic implications

Major Depressive Disorder and Bipolar Disorder Predispose Youth to Accelerated Atherosclerosis and Early Cardiovascular Disease

Oxidative metabolism may be associated with negative symptoms in schizophrenia

Contact Info

Product

Resources

About