Changes in neurons of certain regions of the brain under the influence of nivaline

Treating disorders across the lifespan by modulating cholinergic signaling with galantamine

“…Galantamine (also known as galanthamine) is a plant alkaloid with a long history of being explored in the treatment of cognitive impairment and many other conditions (Plaitakis & Duvoisin, 1983). As elegantly articulated before, this history appears to have started in ancient Greece.…”

“…As elegantly articulated before, this history appears to have started in ancient Greece. In his epic poems Homer describes the mysterious plant ‘Moly’, which is given to Odysseus by Hermes to help his crew to fight against the amnesic effects of Circe's poison—allegedly a centrally acting anticholinergic drug (Plaitakis & Duvoisin, 1983). Based on empirical evidence it has been suggested that ‘Moly’ might have been the common snowdrop ( Galanthus nivalis ), a plant native of the Balkan Peninsula, and a major natural source of galantamine—a centrally acting cholinergic compound (Plaitakis & Duvoisin, 1983).…”

“…In his epic poems Homer describes the mysterious plant ‘Moly’, which is given to Odysseus by Hermes to help his crew to fight against the amnesic effects of Circe's poison—allegedly a centrally acting anticholinergic drug (Plaitakis & Duvoisin, 1983). Based on empirical evidence it has been suggested that ‘Moly’ might have been the common snowdrop ( Galanthus nivalis ), a plant native of the Balkan Peninsula, and a major natural source of galantamine—a centrally acting cholinergic compound (Plaitakis & Duvoisin, 1983). Thus, Homer may have described the first example of applying galantamine to stimulate brain cholinergic signaling and prevent severe anticholinergic poisoning and memory loss.…”