Changes in Mouse Adrenal Gland Functionality Under Second-Generation Chronic Exposure to Elf Magnetic Fields. I. Males

Picazo, M. L.; Miguel, María P. De; Romo, M. A.; Varela, L.; Gianonatti, C; Bardasano, J. L.

doi:10.3109/15368379609009825

Cited by 8 publications

(5 citation statements)

References 23 publications

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“…Similar findings have previously been found by other authors after stimulation of the hypothalamic-hypophyseal-adrenal axis by the administration of ACTH or by different stressful conditions (56,57). Undetectable variations of ACTH plasma levels or the loss of its daily rhythmic secretion can provoke a chronic stimulation of the adrenal cortex and, consequently, adrenocortical hyperfunction with loss of the daily rhythm of cortisol secretion (56).…”

Section: Electromagn Biol Med Downloaded From Informahealthcarecom Bsupporting

confidence: 70%

Inhibition of Melatonin in the Plasma of Third-Generation Male Mice under the Action of ELF Magnetic Fields

Picazo

Catalá

Romo³

et al. 1998

Electro- and Magnetobiology

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2 3 4 ABSTRACTThe pineal gland has been considered a magnetic receptor organ that regulates circadian rhythms by means of the secretion of melatonin, a potent oncostatic agent that prevents the initiation and promotion of cancer. ELF electromagnetic radiation, similar to that generated by power lines, can alter melatonin plasma levels.To study this effect, 4 OF1 mice generations have been reared subjected to a lifelong 15 pT, 50 Hz magnetic field action. This magnetic field was generated inside a Helmholtz coil system. The concentration of melatonin in the blood has been determined on 40 male mice of the third generation by means of RIA, as they reached sexual maturity (3 months). Electromagn Biol Med Downloaded from informahealthcare.com by ThULB Jena on 11/17/14For personal use only. 76 PICAZO E T AL.A radical decrease, more remarkable at night, of the melatonin plasma levels and the loss of the night-day secretion rhythm was observed in the experimental group. These results could be the consequence of the applied magnetic field cumulative effect. The secretion rhythms of other hormones, at the level of the hypothalamic-hypophyseal axis, might be altered as an effect of those results. This chronobiological change could explain the different findings in the 4 generations of mice subjected to the same experimental model.

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Section: Electromagn Biol Med Downloaded From Informahealthcarecom Bsupporting

confidence: 70%

Inhibition of Melatonin in the Plasma of Third-Generation Male Mice under the Action of ELF Magnetic Fields

Picazo

Catalá

Romo³

et al. 1998

Electro- and Magnetobiology

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“…The functional significance of this relationship is not fully elucidated, but several evidences suggest that it represents an aspect of a more complex pattern of coordinated responses to stress which comprise changes in pain sensitivity and blood pressure [Zamir, 1986]. In addition, cardiovascular regulation has been reported to be influenced by exposure to an abnormal electromagnetic environment [Korpinen and Partanen, 1994;Stoupel et al, 1995;Braune et al, 1998;Ghione et al, 1998;Sastre et al, 1998;Sait et al, 1999;Graham et al, 2000a,b;Okano and Ohkubo, 2001;Gmitrov and Ohkubo, 2002], and stress hormone levels have been found to be affected by EMFs [Anderson, 1990;Reiter, 1993;de Bruyn and de Jager, 1994;Picazo et al, 1996].…”

Section: Introductionmentioning

confidence: 99%

Human head exposure to a 37 Hz electromagnetic field: Effects on blood pressure, somatosensory perception, and related parameters

Ghione

Seppia

Mezzasalma

et al. 2004

Bioelectromagnetics

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Previous studies have shown that exposure to an electromagnetic field (EMF) of 37 Hz at a flux density of 80 microT peak enhances nociceptive sensitivity in mice. Here we examined the effects on pain sensitivity and some indexes of cardiovascular regulation mechanisms in humans by measuring electrical cutaneous thresholds, arterial blood pressure, heart rate and its variability, and stress hormones. Pain and tolerance thresholds remained unchanged after sham exposure but significantly decreased after electromagnetic exposure. Systolic blood pressure was significantly higher during electromagnetic exposure and heart rate significantly decreased, both during sham and electromagnetic exposure, while the high frequency (150-400 mHz) component of heart rate variability, which is an index of parasympathetic activity, increased as expected during sham exposure but remained unchanged during electromagnetic exposure. Cortisol significantly decreased during sham exposure only. These results show that exposure to an EMF of 37 Hz also alters pain sensitivity in humans and suggest that these effects may be associated with abnormalities in cardiovascular regulation.

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“…While the majority of papers failed to find any effect, [131][132][133][134][135][136][137] others have reported either an increase in the hormonal concentrations [138][139][140][141][142][143][144] or a decreased concentration. 145 The results of these studies are thus inconsistent and contradictory.…”

Section: T R a N S L A T I O N A L R E S E A R C Hmentioning

confidence: 99%

“…Free et al, 1981 131 Quinlan et al, 1985 132 Portet and Cabanes, 1988 133 Thompson et al, 1995 134 Burchard et al, 1996 135 Szemerszky et al, 2010 136 Martinez-Samano et al, 2012 137 Hackman and Graves, 1981 138 Gorczynska and Wegrzynowicz, 1991 139,140 de Bruyn and de Jager, 1994 141 Picazo et al, 1996 142 Bonhomme-Faivre et al, 1998 145 Marino et al, 2001 143 T r a n s l a t i o n a l r e s e a r c h must be given when comparing data obtained in different animal species, even within a group as rodents, since differences have been described between rodent species and even between pigmented and albino breeds.…”

Section: Reference Of the Studymentioning

confidence: 99%

The effects of extremely low-frequency magnetic fields on melatonin and cortisol, two marker rhythms of the circadian system

Touitou

Selmaoui

2012

Dialogues in Clinical Neuroscience

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In the past 30 years the concern that daily exposure to extremely low-frequency magnetic fields (ELF-EMF) (1 to 300 Hz) might be harmful to human health (cancer, neurobehavioral disturbances, etc) has been the object of debate, and has become a public health concern. This has resulted in the classification of ELF-EMF into category 2B, ie, agents that are "possibly carcinogenic to humans" by the International Agency for Research on Cancer. Since melatonin, a neurohormone secreted by the pineal gland, has been shown to possess oncostatic properties, a "melatonin hypothesis" has been raised, stating that exposure to EMF might decrease melatonin production and therefore might promote the development of breast cancer in humans. Data from the literature reviewed here are contradictory. In addition, we have demonstrated a lack of effect of ELF-EMF on melatonin secretion in humans exposed to EMF (up to 20 years' exposure) which rebuts the melatonin hypothesis. Currently, the debate concerns the effects of ELF-EMF on the risk of childhood leukemia in children chronically exposed to more than 0.4 μT. Further research is thus needed to obtain more definite answers regarding the potential deleterious effects of ELF-EMF.

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Changes in Mouse Adrenal Gland Functionality Under Second-Generation Chronic Exposure to Elf Magnetic Fields. I. Males

Cited by 8 publications

References 23 publications

Inhibition of Melatonin in the Plasma of Third-Generation Male Mice under the Action of ELF Magnetic Fields

Inhibition of Melatonin in the Plasma of Third-Generation Male Mice under the Action of ELF Magnetic Fields

Human head exposure to a 37 Hz electromagnetic field: Effects on blood pressure, somatosensory perception, and related parameters

The effects of extremely low-frequency magnetic fields on melatonin and cortisol, two marker rhythms of the circadian system

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