The effects of extremely low-frequency magnetic fields on melatonin and cortisol, two marker rhythms of the circadian system

Touitou, Yvan; Selmaoui, Brahim

doi:10.31887/dcns.2012.14.4/ytouitou

Cited by 57 publications

(17 citation statements)

References 134 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, objective assessment should be conducted for symptomatic patients with muscle fatigue and pain, in more severe cases, patients with ischemic disorders such as atherosclerosis and diabetes, to clarify the effects and mechanisms of 50 Hz MFs on ischemic regions. In addition, by exposure to 50 Hz MFs, there is a possibility that some specific biomarkers, such as melatonin, cortisol, serotonin and dopamine, could be affected [ 43 , 44 ] and/or pain perception pathways via opioid receptors could be inhibited [ 45 ]. Further studies should be needed to investigate the MF-based therapeutic applications and elucidate the underlying mechanisms of MF effects on pain relief and recovery of muscle fatigue.…”

Section: Discussionmentioning

confidence: 99%

A 50 Hz magnetic field affects hemodynamics, ECG and vascular endothelial function in healthy adults: A pilot randomized controlled trial

et al. 2021

View full text Add to dashboard Cite

Application of exposure to 50/60 Hz magnetic fields (MFs) has been conducted in the treatment of muscle pain and fatigue mainly in Japan. However, whether MFs could increase blood flow leading to muscle fatigue recovery has not been sufficiently tested. We investigated the acute effects of a 50 Hz sinusoidal MF at Bmax 180 mT on hemodynamics, electrocardiogram, and vascular endothelial function in healthy young men. Three types of regional exposures to a 50 Hz MF, i.e., forearm, upper arm, or neck exposure to MF were performed. Participants who received three types of real MF exposures had significantly increased ulnar arterial blood flow velocity compared to the sham exposures. Furthermore, after muscle loading exercise, MF exposure recovered hemoglobin oxygenation index values faster and higher than sham exposure from the loading condition. Moreover, participants who received real MF exposure in the neck region had significantly increased parasympathetic high-frequency activity relative to the sham exposure. The MF exposure in the upper arm region significantly increased the brachial artery flow-mediated dilation compared to the sham exposure. Computer simulations of induced in situ electric fields indicated that the order-of-magnitude estimates of the peak values were 100–500 mV/m, depending on the exposure conditions. This study provides the first evidence that a 50 Hz MF can activate parasympathetic activity and thereby lead to increase vasodilation and blood flow via a nitric oxide-dependent mechanism. Trial registration: UMIN Clinical Trial Registry (CTR) UMIN000038834. The authors confirm that all ongoing and related trials for this drug/intervention are registered.

show abstract

Section: Discussionmentioning

confidence: 99%

A 50 Hz magnetic field affects hemodynamics, ECG and vascular endothelial function in healthy adults: A pilot randomized controlled trial

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Several factors, like light pollution during night or moving across time zones, may lead to the disruption of the melatonin secretion rhythm and circadian disorganization, which undoubtedly has a negative impact on various aspects of health [ 13 , 14 , 16 , 24 , 25 ].…”

Section: Effects Of Electric Magnetic and Electromagnetic Fieldsmentioning

confidence: 99%

“…The epidemiological studies provided interesting and very important data on the influence of electromagnetic fields on melatonin and its metabolite—6-sulfatoxymelatonin—in humans. Many of these investigations concerned the effects of an extremely low frequency magnetic field (ELF-MF), which is generated by outdoor high- and medium-voltage electricity power lines, indoor electrical power supply, and electrical appliances [ 25 ].…”

Section: Effects Of Electric Magnetic and Electromagnetic Fieldsmentioning

confidence: 99%

Influence of Electric, Magnetic, and Electromagnetic Fields on the Circadian System: Current Stage of Knowledge

Lewczuk

Redlarski

Żak

et al. 2014

BioMed Research International

View full text Add to dashboard Cite

One of the side effects of each electrical device work is the electromagnetic field generated near its workplace. All organisms, including humans, are exposed daily to the influence of different types of this field, characterized by various physical parameters. Therefore, it is important to accurately determine the effects of an electromagnetic field on the physiological and pathological processes occurring in cells, tissues, and organs. Numerous epidemiological and experimental data suggest that the extremely low frequency magnetic field generated by electrical transmission lines and electrically powered devices and the high frequencies electromagnetic radiation emitted by electronic devices have a potentially negative impact on the circadian system. On the other hand, several studies have found no influence of these fields on chronobiological parameters. According to the current state of knowledge, some previously proposed hypotheses, including one concerning the key role of melatonin secretion disruption in pathogenesis of electromagnetic field induced diseases, need to be revised. This paper reviews the data on the effect of electric, magnetic, and electromagnetic fields on melatonin and cortisol rhythms—two major markers of the circadian system as well as on sleep. It also provides the basic information about the nature, classification, parameters, and sources of these fields.

show abstract

“…MFs are either of natural origin (geomagnetic field, intense solar activity, thunderstorms) or human-made (factories, transmission lines, electric appliances at work and home, magnetic resonance imaging, medical treatment, etc.) [ 2 ]. Common used frequencies of electric and magnetic fields of the electric power supply and of electric and magnetic fields generated by electricity power lines and electric/electronic devices are 50 Hz in Europe and 60 Hz in North America [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

“…[ 2 ]. Common used frequencies of electric and magnetic fields of the electric power supply and of electric and magnetic fields generated by electricity power lines and electric/electronic devices are 50 Hz in Europe and 60 Hz in North America [ 2 ]. Biological effects of ELF-MF and their consequences on human health have become the subject of important and recurrent public debate.…”

Section: Introductionmentioning

confidence: 99%

Extremely Low-Frequency Magnetic Field as a Stress Factor—Really Detrimental?—Insight into Literature from the Last Decade

Klimek

Rogalska

2021

Brain Sciences

View full text Add to dashboard Cite

Biological effects of extremely low-frequency magnetic field (ELF-MF) and its consequences on human health have become the subject of important and recurrent public debate. ELF-MF evokes cell/organism responses that are characteristic to a general stress reaction, thus it can be regarded as a stress factor. Exposure to ELF-MF “turns on” different intracellular mechanisms into both directions: compensatory or deleterious ones. ELF-MF can provoke morphological and physiological changes in stress-related systems, mainly nervous, hormonal, and immunological ones. This review summarizes the ELF-MF-mediated changes at various levels of the organism organization. Special attention is placed on the review of literature from the last decade. Most studies on ELF-MF effects concentrate on its negative influence, e.g., impairment of behavior towards depressive and anxiety disorders; however, in the last decade there was an increase in the number of research studies showing stimulating impact of ELF-MF on neuroplasticity and neurorehabilitation. In the face of numerous studies on the ELF-MF action, it is necessary to systematize the knowledge for a better understanding of the phenomenon, in order to reduce the risk associated with the exposure to this factor and to recognize the possibility of using it as a therapeutic agent.

show abstract

The effects of extremely low-frequency magnetic fields on melatonin and cortisol, two marker rhythms of the circadian system

Cited by 57 publications

References 134 publications

A 50 Hz magnetic field affects hemodynamics, ECG and vascular endothelial function in healthy adults: A pilot randomized controlled trial

A 50 Hz magnetic field affects hemodynamics, ECG and vascular endothelial function in healthy adults: A pilot randomized controlled trial

Influence of Electric, Magnetic, and Electromagnetic Fields on the Circadian System: Current Stage of Knowledge

Extremely Low-Frequency Magnetic Field as a Stress Factor—Really Detrimental?—Insight into Literature from the Last Decade

Contact Info

Product

Resources

About