Changes in monoamines in rat hypothalamus during cold acclimation

Saito, Takushi; Ishiwata, Takayuki; Hasegawa, Hiroshi; Nomoto, Shigeki; Otokawa, Minoru; Aihara, Yasutsugu

doi:10.1016/j.jtherbio.2004.12.001

Cited by 10 publications

(6 citation statements)

References 35 publications

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“…group was smaller. However, a similar reduction in T b was not observed at 5°C in male rats [20,21]. Hosono et al [8] reported that the T b during a 3-h cold exposure at 4°C was higher in ovariectomized rats with E 2 than in those without E 2 .…”

Section: Methodsmentioning

confidence: 86%

Estrogen modulates central and peripheral responses to cold in female rats

et al. 2009

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The aim of this study was to determine whether estrogen modulates central and peripheral responses to cold in female rats. In ovariectomized female rats with and without administered estrogen [E(2) (+) and E(2) (-), respectively], the counts of cFos-immunoreactive cells in the medial preoptic nucleus (MPO) and dorsomedial hypothalamic nucleus (DMH) in the hypothalamus were greater in the E(2) (+) rats than in the E(2) (-) rats at 5 degrees C. Examination of the response of normal female rats to exposure to 5 degrees C at different phases of the estrus cycle revealed that counts of cFos-immunoreactive cells in the MPO, DMH, and posterior hypothalamus and the level of uncoupling protein 1 mRNA in the brown adipose tissues were greater in the proestrus phase than on day 1 of the diestrus phase. This result was linked to the level of plasma estrogen. The body temperature during cold exposure was higher in the E(2) (+) rats than in the E(2) (-) rats and was also higher in the proestrus phase than on day 1 of the diestrus phase. We conclude that estrogen may affect central and peripheral responses involved in thermoregulation in the cold.

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Section: Methodsmentioning

confidence: 86%

Estrogen modulates central and peripheral responses to cold in female rats

et al. 2009

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“…peritoneal cavities, which allowed continuous monitoring of T c and heart rate (HR), an indicator of heat production (Chambers et al, 2000;Hasegawa et al, 2005;Ishiwata et al, 2005;Saito et al, 2005). We measured the tail skin temperature (T t ), an index of heat loss response on dorsal surface of the skin ca.…”

Section: Thermoregulatory Parameter Measurementsmentioning

confidence: 99%

“…Rats were divided randomly into the RA group (N = 6), kept at an ambient temperature (T a ) of 23°C for 2 weeks, and a CA group (N = 6), kept at a T a of 5°C for 2 weeks in a temperature-controlled chamber (Ishiwata et al, 2002Saito et al, 2005).…”

Section: Temperature Acclimationmentioning

confidence: 99%

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Effect of chronic cold exposure on noradrenergic modulation in the preoptic area of thermoregulation in freely moving rats

et al. 2008

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“…Stress exposure influences body homeostasis, leading to different physiological responses but may also cause development of various pathological conditions. Physical and psychological stress is already known to induce sympathetic activity and the hypothalamic-pituitary-adrenal (HPA) axis, which activates synthesis of neuropeptides and catecholamine (SAITO et al 2005). Catecholamine metabolism leads to production of reactive oxygen species (ROS) that may influence cellular redox homeostasis and oxygen radical toxicity (MEISER et al 2013).…”

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confidence: 99%

Antioxidant Enzymes in Brain Cortex of Rats Exposed to Acute, Chronic and Combined Stress

Pejić¹,

Stojikjkovic²,

Todorović³

et al. 2016

folia biol (krakow)

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Antioxidant enzymes in brain cortex of rats exposed to acute, chronic and combined stress. Folia Biologica (Kraków) 64: 189-195. The study deals with manganese superoxide dismutase, copper, zinc superoxide dismutase, and catalase activities in brain cortex of Wistar rats exposed to acute stress (immobilization or cold for 2 h), chronic stress (long-term isolation or long-term forced swimming for 21 days), or to combined chronic/acute stress. We observed that i) single episodes of acute stress by immobilization increased activity of both superoxide dismutases; ii) both types of chronic stresses significantly elevated activities of all examined enzymes; iii) chronic social isolation was a much stronger stressor than physical stress by swimming; iv) in animals pre-exposed to chronic isolation, additional stress by immobilization or cold significantly decreased previously elevated activities of all enzymes, while after chronic swimming, acute immobilization lowered only catalase activity. The obtained results indicate that stress conditions most probably altered the cell redox equilibrium, thus influencing the antioxidant response in brain cortex. Further investigation of neuronal prooxidant/antioxidant cellular conditions is needed to improve the prevention and treatment of various stress induced diseases.

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Changes in monoamines in rat hypothalamus during cold acclimation

Cited by 10 publications

References 35 publications

Estrogen modulates central and peripheral responses to cold in female rats

Estrogen modulates central and peripheral responses to cold in female rats

Effect of chronic cold exposure on noradrenergic modulation in the preoptic area of thermoregulation in freely moving rats

Antioxidant Enzymes in Brain Cortex of Rats Exposed to Acute, Chronic and Combined Stress

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