Effect of chronic cold exposure on noradrenergic modulation in the preoptic area of thermoregulation in freely moving rats

Saito, Takushi; Ishiwata, Takayuki; Hasegawa, Hiroshi; Nomoto, Shigeki; Kotani, Yasunori; Otokawa, Minoru; Aihara, Yasutsugu

doi:10.1016/j.lfs.2008.05.008

Cited by 5 publications

(6 citation statements)

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“…This finding suggests the contribution of hypothalamus and endocrine system-mediated mechanisms, triggered by stress in vivo , in order to increase TOS levels [4, 27]. Findings from this study indicate that ex vivo cold exposure does not change plasma TAS levels compared to in vivo exposure groups.…”

Section: Discussionmentioning

confidence: 65%

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The effects of in vivo and ex vivo various degrees of cold exposure on erythrocyte deformability and aggregation

Erken

Bor-Küçükatay

et al. 2011

Med Sci Monit

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SummaryBackgroundThis study aimed to investigate alterations in hemorheology by cold exposure, in vivo and ex vivo, and to determine their relationship to oxidative stress.Material/MethodsRats were divided into 2 in vivo and ex vivo cold exposure groups. The in vivo group was further divided into control (AR), AC (4°C, 2 hours) and ALTC (4°C, 6 hours) subgroups; and the ex vivo group was divided into control (BR) and BC (4°C, 2 hours) subgroups. Blood samples were used for the determination of erythrocyte deformability, aggregation, and oxidative stress parameters.ResultsErythrocyte deformability and aggregation were not affected by 2-hour ex vivo cold exposure. While 2 hour in vivo cold exposure reduced erythrocyte deformability, it returned to normal after 6 hours, possibly due the compensation by acute neuroendocrine response. Six hours of cold exposure decreased aggregation index, and might be an adaptive mechanism allowing the continuation of circulation. Aggregation of ex vivo groups was lower compared to in vivo groups. Cold exposure at various temperatures did not cause alterations in plasma total oxidant antioxidant status and oxidative stress index (TOS, TAS, OSI) when considered together.ConclusionsResults of this study indicate that the alterations observed in hemorheological parameters due to cold exposure are far from being explained by the oxidative stress parameters determined herein.

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Section: Discussionmentioning

confidence: 65%

“…Increase in noradrenaline and cortisol secretion due to cold has previously been demonstrated [4,27]. Stress hormones such as catecholamines and cortisol may be responsible for the hemorheological alterations during stress by an indirect effect on lipids [28].…”

Section: Discussionmentioning

confidence: 99%

The effects of in vivo and ex vivo various degrees of cold exposure on erythrocyte deformability and aggregation

Erken

Bor-Küçükatay

et al. 2011

Med Sci Monit

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“…Esta ferramenta farmacológica promoveu uma acentuada hipotermia com bradicardia somente na exposição aguda ao frio. Desta forma, a NA na mPOA modula a termoregulação em resposta ao estresse pelo frio agudo via adrenoceptores alfa-1 e não na sua forma crônica já que outros receptores estão agindo que não adrenoceptores alfa-1 (SAITO et al, 2008).…”

Section: Estresse E Função Pineal -Tese De Doutorado -Delineamento E unclassified

“…Outros autores não observaram qualquer modificação plasmática (DRONJAK e GAVRILOVIC, 2006). De forma semelhante, os níveis de noradrenalina são afetados pelo estresse de diferentes maneiras, então aumento foi encontrado no plasma (JEDEMA et al, 1999;PAJOVIĆ et al, 2006) e no sistema nervoso central (FINLAY et al, 1997;MURPHY et al, 2003;MA e MORILAK, 2005a;SAITO et al, 2008;BUFFALARI e GRACE, 2009;), bem como decréscimo no plasma (DRONJAK e GAVRILOVIC, 2006) e no sistema nervoso central (HELLRIEGEL e D'MELLO, 1997;DRONJAK e GAVRILOVIC, 2006) são também observados, além de nenhuma alteração da noradrenalina no sistema Estresse e Função Pineal -Tese de Doutorado -Discussão 204 nervoso central (JEDEMA et al, 1999;SALLINEN et al, 1999).…”

Section: Estresse E Função Pineal -Tese De Doutorado -Delineamento E unclassified

“…A competência do estresse em modular os adrenoceptores tem grande variação na literatura conforme apresentado nesta discussão, assim no sentido de relembrar estes tantos efeitos relatados apresentamos a seguir um resumo. O estresse foi capaz de modular adrenoceptores alfa-1 (MA e MORILAK, 2005a;MA e MORILAK, 2005b;SAITO et al, 2008;CRESTANI et al, 2009), adrenoceptores alfa-1B (WILLIAMS e MORILAK, 1997;, adrenoceptores alfa-2 (NUKINA et al, 1987;ORTIZ et al, 2008), adrenoceptores alfa-2C (SALLINEN et al, 1999), adrenoceptores beta sem subtipo especificado (ZAFAR et al, 1997), adrenoceptores beta-1 (CAPAZ e DE MORAES, 1988), adrenoceptores beta-2 , e também adrenoceptores beta- 3 (TILLINGER et al, 2008). al., 2007).…”

Section: Estresse E Função Pineal -Tese De Doutorado -Delineamento E unclassified

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Papel da corticosterona na vigência do estresse sobre a função pineal em ratos.

Moraes¹

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Changes in thermoregulation and monoamine release in freely moving rats during cold exposure and inhibition of the ventromedial, dorsomedial, or posterior hypothalamus

Ishiwata

Greenwood

2017

J Comp Physiol B

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The hypothalamus is critical for regulating thermogenesis, but the role of monoamines in specific hypothalamic subregions in thermogenesis is not thoroughly established. The purpose of this study was to confirm changes of body temperature (T ) and thermoregulatory parameters upon inhibition of neural activity in hypothalamic subregions in freely moving rats. In addition, the pattern of monoamine release in these nuclei was measured during active thermoregulation using microdialysis. Tetrodotoxin (TTX) was perfused into the ventromedial hypothalamus (VMH), dorsomedial hypothalamus (DMH), or posterior hypothalamus (PH) at two different ambient temperatures (5 or 23 °C). Using telemetry, we continuously measured the T and the heart rate (HR) as an index of heat production as well as locomotor activity (Act). Tail skin temperature (T ) was also continuously measured as an index of heat loss. Although the perfusion of TTX into hypothalamic subregions had no effect on any of the measured thermoregulatory parameters at an ambient temperature of 23 °C, it induced significant T decrease under cold conditions only when perfused into the DMH and the PH. In contrast, the HR decreased only after perfusion of TTX into the PH during cold conditions, while the T and Act remained unchanged. Serotonin (5-HT) in the DMH and dopamine (DA) metabolite 3,4-Dihydroxyphenylacetic acid in the PH, but not noradrenaline, increased significantly during exposure to cold temperatures. Our results indicate that the DMH and the PH, but not the VMH, are particularly involved in heat production under cold conditions. In addition, 5-HT in the DMH and DA in the PH may be involved in thermogenesis.

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Effect of chronic cold exposure on noradrenergic modulation in the preoptic area of thermoregulation in freely moving rats

Cited by 5 publications

References 68 publications

The effects of in vivo and ex vivo various degrees of cold exposure on erythrocyte deformability and aggregation

The effects of in vivo and ex vivo various degrees of cold exposure on erythrocyte deformability and aggregation

Papel da corticosterona na vigência do estresse sobre a função pineal em ratos.

Changes in thermoregulation and monoamine release in freely moving rats during cold exposure and inhibition of the ventromedial, dorsomedial, or posterior hypothalamus

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