Changes in malondialdehyde concentrations and glutathione peroxidase activity in purebred Arabian mares with endometritis

Yaralioglu-Gurgoze, Sema

doi:10.1016/s1090-0233(04)00086-3

Cited by 2 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Unfavourable effects of this phenomenon, manifested mainly by tissue damage, also in the area of the reproductive system of a female, were an impulse for numerous studies (4,6,10). Interesting results were obtained by Yaralioglu-Gurgoze et al (36), who demonstrated a significantly lower erythrocytic glutathione peroxidase (GPx) activity in mares with endometritis in comparison to the healthy ones. This result can suggest an insufficient elimination of ROS in sick animals, the more so that this phenomenon was accompanied by a clear increase in malondialdehyde (MDA) content, which is one of the final products of lipid peroxidation in cellular membranes.…”

Section: Discussionmentioning

confidence: 99%

“…Germicidal potential of these fastest reacting and dominating cells is mainly conditioned by formation of reactive oxygen species (ROS) (17). It is believed that disturbances in the prooxidative-antioxidative balance may play a role in pathogenesis of a number of uterine diseases such as cervicitis, uterine myoma (10), uterine lymphatic cysts (4), endometritis (36). It was also demonstrated that phagocytic and chemotactic activity of polymorphonuclear cells (PMN) in the uterus and periphery is different in mares susceptible and resistant to chronic uterine infection -CUI (3,13,28).…”

mentioning

confidence: 99%

See 1 more Smart Citation

Chemiluminescence of Peripheral Blood Neutrophils in Mares with Endometritis

Krumrych

Daněk

2012

Bulletin of the Veterinary Institute in Pulawy

View full text Add to dashboard Cite

The aim of the study was to evaluate the oxygen metabolism of neutrophils in peripheral blood of mares in relation to intensity of endometrium inflammations. The study involved 36 half-breed mares, aged 4-22 years, showing fertility disturbances. In 26 mares neutrophils were found in uteral smears, which indicated endometritis (15 - moderate inflammation and 11 - severe inflammation). In the rest mares, cytological examination excluded inflammation. Blood samples were evaluated in terms of neutrophils chemiluminescence without stimulation (CL-WS) and with stimulation by opsonised zymosan (CL-OZ). The study demonstrated (only in case of CL-WS) an increase in chemiluminescence of cells in mares with a severe inflammation of the endometrium. The increased chemiluminescence activity was accompanied by a decrease in activation index (OZ/WS) of neutrophils, suggesting some imbalance between production and elimination of reactive oxygen species (ROS). The correlation analysis demonstrated a statistically significant relation between the intensity of the uterus inflammation, which was verified by cytological examination and CL-WS of peripheral blood neutrophils, as well as their activation index. The obtained results suggest that activated neutrophils are an important source of ROS which can play a role in the pathogenesis of endometritis in mares.

show abstract

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Chemiluminescence of Peripheral Blood Neutrophils in Mares with Endometritis

Krumrych

Daněk

2012

Bulletin of the Veterinary Institute in Pulawy

View full text Add to dashboard Cite

show abstract

“…The addition of CoQ in the ejaculate does not seem to perform particular antioxidant action; however, in the uterus CoQ and ubiquinol may be involved in the mechanism of inhibition of post-coital endometritis. The effect of reduction of post-coital endometritis performed by equine seminal plasma has already been demonstrated (Troedsson et al 2001), and OS has been proposed as a potential factor involved in the pathogenesis of the endometritis in mares (Yaralioglu-Gurgoze et al 2005). Some authors demonstrated that intramuscular treatments with antioxidants increase the recovery rate in chronic endometritis in cows (Segupta & Nandi 2013).…”

Section: Discussionmentioning

confidence: 99%

Role of coenzyme Q and vitamin E on stallion semen motility evaluated both in frozen and cooled-stored semen

Rossi

Falomo

Mantovani

2016

Italian Journal of Animal Science

View full text Add to dashboard Cite

Several studies reveal that coenzyme Q (CoQ) and vitamin E (Vit. E) act against oxidative deterioration, and that CoQ restores the active and antioxidant form of Vit. E. These two antioxidants, acting against lipid peroxidation, seem to be able to improve motility parameters of spermatozoa. The objective of this study is to evaluate the addition of CoQ and Vit. E to semen extender for equine spermatozoa in order to evaluate possible effects on semen motility. First, immediately after collection, semen samples were diluted with 1mM of CoQ and 1mM of CoQ plus 1mM of Vit. E and prepared for frozen storage in liquid nitrogen. After thawing (37 C/30 s), samples were maintained at 37 C and subjected to analysis after 0, 2 and 4 h for motility parameters with CASA (Computer-Assisted Sperm Analysis) method. In a second experiment, after the collection, semen samples were diluted with 1mM of CoQ, in presence or absence of seminal plasma where Vit. E is normally present, and prepared for cooled storage at 4 C. The effects on motility parameters were determined with CASA at 0, 24, 31 and 48 h after collection. During the analysis, samples were kept at 4 C. The CASA variables were examined with a mixed linear model. No improvement (p > .05) in motility parameters results from the addition of CoQ and Vit. E in frozen or cooled-stored equine semen when compared to control group.

show abstract

Changes in malondialdehyde concentrations and glutathione peroxidase activity in purebred Arabian mares with endometritis

Cited by 2 publications

References 0 publications

Chemiluminescence of Peripheral Blood Neutrophils in Mares with Endometritis

Chemiluminescence of Peripheral Blood Neutrophils in Mares with Endometritis

Role of coenzyme Q and vitamin E on stallion semen motility evaluated both in frozen and cooled-stored semen

Contact Info

Product

Resources

About