Changes in lung function in patients with human T cell lymphotropic virus (HTLV) associated myelopathy residents in the eastern Brazilian Amazon

Normando, Valéria Marques Ferreira; Falcão, Luiz Fábio Magno; Vieira, Waldonio de Brito; Oliveira, Robson Tadachi Moraes de; Santos, Márcio Clementino de Souza; Fuzii, Hellen Thaís; Quaresma, Juarez Antônio Simões

doi:10.1183/13993003.congress-2016.pa4442

Cited by 3 publications

(7 citation statements)

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“…Our spirometry analysis showed a decrease in lung function related to the lung injuries observed in the chest CT; this patient group showed a tendency of decline in VC, FVC, FEV1, FEF 25-75%, and MVV values. Previous studies have shown that lung injury and altered lung function is more common in TSP-HAM individuals [ 7 , 11 ], verifying the principal degree of lung involvement among those who developed the inflammatory form of the disease from HTLV-1.…”

Section: Discussionmentioning

confidence: 78%

“…The major radiological findings are bronchiectasis, centrilobular nodules and ground glass opacities [ 4 – 6 ]; these lung injuries are attributable to chronic inflammation resulting from the effects of the virus in situ [ 7 – 10 ]. This lung inflammation is possibly the causal agent of obstruction of lung volume, flow limitation, and the development of restrictive and obstructive lung diseases, specifically, in tropical spastic paraparesis/HTLV-1-associated myelopathy (TSP-HAM) patients [ 7 , 9 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

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Computed tomography with 6-year follow-up demonstrates the evolution of HTLV-1 related lung injuries: A cohort study

et al. 2021

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Previous observational studies have demonstrated the development of pulmonary impairments in human T-lymphotropic virus type 1 (HTLV-1) infected individuals. The main observed lesions due to chronic inflammation of viral infection in situ are bronchiectasis and lung-scarring injuries. This lung inflammation may be the causal agent of restrictive and obstructive lung diseases, primarily in tropical spastic paraparesis/HTLV-1-associated myelopathy (TSP-HAM) patients. We conducted a prospective cohort study to compare spirometry and high-resolution computed tomography (HRCT) findings among 28 HTLV-1-carrier patients over the course of 6 years (2014–2019) (male/female: 7/21; mean age: 54.7 ± 9.5, range: 41–68 years). Chest HRCT exams revealed the development and evolution of lung lesions related to TSP-HAM: including centrilobular nodules, parenchymal bands, lung cysts, bronchiectasis, ground-glass opacity, mosaic attenuation, and pleural thickening. Spirometry exams showed maintenance of respiratory function, with few alterations in parameters suggestive of obstructive and restrictive disorders primarily in individuals with lung lesions and TSP-HAM. The findings of the present study indicate that pulmonary disease related to HTLV-1 is a progressive disease, with development of new lung lesions, mainly in individuals with TSP-HAM. To improve clinical management of these individuals, we recommend that individuals diagnosed with PET-MAH undergo pulmonary evaluation.

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Section: Discussionmentioning

confidence: 78%

Section: Introductionmentioning

confidence: 99%

Computed tomography with 6-year follow-up demonstrates the evolution of HTLV-1 related lung injuries: A cohort study

et al. 2021

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“…We show that may be a relationship between HTLV-1 infection and changes in pulmonary function, especially in individuals with HAM/TSP, which may progress to obstructive or restrictive lung disease, possibly related to pulmonary inflammation ( Normando et al, 2016 ; Falcão et al, 2017 ). A previous study observed obstructive disease in a suspect patient of bronchiolitis obliterans that was identified as HTLV-1 associated bronchioloalveolar disorder (HABA) with 1.25 l forced expiration volume in one second (FEV 1 ) (74.4% of predicted) and 64.1% forced expiratory volume in one second/forced vital capacity (FEV 1 /FVC) ( Yamakawa et al, 2015 ) due Adult T-cell leukemia ( Kimura, 1992 ).…”

Section: Ct Findings and Pulmonary Functionmentioning

confidence: 82%

Human T Lymphotropic Virus and Pulmonary Diseases

Dias

Falcão

et al. 2018

Front. Microbiol.

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Human T lymphotropic virus type 1 (HTLV-1) is the etiological agent of HTLV-1-associated myelopathy, and adult T cell lymphoma/leukemia (ATL/L). Pulmonary complications such as alveolitis and bronchiectasis were found in individuals who develop TSP/HAM due to chronic inflammation. These individuals showed image anomalies in CT scans and changes in pulmonary function parameters distinctive of pulmonary disease. Furthermore, infected individuals have a greater susceptibility to pulmonary tuberculosis either due to changes in the innate immune response, in asymptomatic carriers, or to an opportunistic disease linked to immunodepression, in individuals who develop ATL/L. This summary addresses the general lack of knowledge regarding the relationship between HTLV-1 and pulmonary diseases and provides direction for future work.

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“…Individuals with TSP-HAM can develop changes in pulmonary function, due to pulmonary inflammation and lung lesions, which may progress to obstructive or restrictive lung disease (17,21). An analysis of pulmonary function in these individuals showed a reduction in vital capacity (VC) and forced expiratory volume in one second (FEV1), these alterations are related to restrictive lung disease, and airway obstruction, respectively (17).…”

Section: Pulmonary Functionmentioning

confidence: 99%

“…TSP-HAM individuals have a major risk to development of lung injuries, being the major radiological findings bronchiectasis, centrilobular nodules, and ground-glass opacities (14)(15)(16); lesions are attributable to chronic inflammation resulting from the effects of the virus in situ (17)(18)(19)(20). Lung inflammation may be the causal agent of lung volume obstruction, flow limitation, and the development of restrictive and obstructive lung diseases in TSP-HAM patients (17,19,21).…”

Section: Introductionmentioning

confidence: 99%

An Overview of Human T-Lymphotropic Virus Type 1 Lung Injury

2022

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Previous studies have demonstrated the development of pulmonary impairment in individuals infected with human T-lymphotropic virus type 1 (HTLV-1). Complications, such as alveolitis and bronchiectasis, were found in individuals who developed tropical spastic paraparesis/HTLV-1-associated myelopathy (TSP-HAM) due to chronic inflammation. These patients exhibited increased levels of lymphocytes (CD4+ and CD25+), cytokines (IL-2, IL-12, and IFN-γ), inflammatory chemokines (MIP-1α and IP-10), and cell adhesion molecules (ICAM-1) in the bronchoalveolar lavage fluid, with the result of chronic inflammation and lung injury. The main lesions observed at Chest high-resolution computed tomography were centrilobular nodules, parenchymal bands, lung cysts, bronchiectasis, ground-glass opacity, mosaic attenuation, and pleural thickening. It can lead to progressive changes in pulmonary function with the development of restrictive and obstructive diseases. Recent studies suggest a causal relationship between HTLV-1 and pulmonary diseases, with intensification of lesions and progressive decrease in pulmonary function. This summary updates a previous publication and addresses the general lack of knowledge regarding the relationship between TSP-HAM and pulmonary disease, providing direction for future work and the management of these individuals.

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Changes in lung function in patients with human T cell lymphotropic virus (HTLV) associated myelopathy residents in the eastern Brazilian Amazon

Cited by 3 publications

References 0 publications

Computed tomography with 6-year follow-up demonstrates the evolution of HTLV-1 related lung injuries: A cohort study

Computed tomography with 6-year follow-up demonstrates the evolution of HTLV-1 related lung injuries: A cohort study

Human T Lymphotropic Virus and Pulmonary Diseases

An Overview of Human T-Lymphotropic Virus Type 1 Lung Injury

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