Changes in Liver Tissue Trace Element Concentrations During Hepatitis B Viral Infection Treatment

Şahin, Muammer Melih; Karayakar, Fahri; Köksal, Ali; Yetim, Aylin; İyisoy, Mehmet Sinan; Şen, İ̇lker; Alkım, Hüseyin; Alkım, Canan; Çolak, Tahsin

doi:10.1007/s12011-018-1414-y

Cited by 9 publications

(10 citation statements)

References 17 publications

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“…Several studies demonstrated a relationship between Pb exposure and susceptibility to viral infections, corroborating its role in suppression of antiviral immunity ( Rashed, 2011 ; Emokpae, Mbonu, 2018 ; Sahin et al, 2019 ), although no association between Pb and airborne viral infections exists.…”

Section: Introductionmentioning

confidence: 96%

Toxic metal exposure as a possible risk factor for COVID-19 and other respiratory infectious diseases

Skalny

Lima

Tao

et al. 2020

Food and Chemical Toxicology

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Multiple medical, lifestyle, and environmental conditions, including smoking and particulate pollution, have been considered as risk factors for CO rona VI rus D isease 2019 (COVID-19) susceptibility and severity. Taking into account the high level of toxic metals in both particulate matter (PM2.5) and tobacco smoke, the objective of this review is to discuss recent data on the role of heavy metal exposure in development of respiratory dysfunction, immunotoxicity, and severity of viral diseases in epidemiological and experimental studies, as to demonstrate the potential crossroads between heavy metal exposure and COVID-19 severity risk. The existing data demonstrate that As, Cd, Hg, and Pb exposure is associated with respiratory dysfunction and respiratory diseases (COPD, bronchitis). These observations corroborate laboratory findings on the role of heavy metal exposure in impaired mucociliary clearance, reduced barrier function, airway inflammation, oxidative stress, and apoptosis. The association between heavy metal exposure and severity of viral diseases, including influenza and respiratory syncytial virus has been also demonstrated. The latter may be considered a consequence of adverse effects of metal exposure on adaptive immunity. Therefore, reduction of toxic metal exposure may be considered as a potential tool for reducing susceptibility and severity of viral diseases affecting the respiratory system, including COVID-19.

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Section: Introductionmentioning

confidence: 96%

Toxic metal exposure as a possible risk factor for COVID-19 and other respiratory infectious diseases

Skalny

Lima

Tao

et al. 2020

Food and Chemical Toxicology

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“…4 Metabolic disorders characterize most liver diseases. Patients with CLD often have alterations in glucose, 5 trace elements, [6][7][8][9][10][11] lipid, 12 and protein metabolism. [13][14][15] The effects of liver diseases on amino acid (AA) metabolism have received widespread attention.…”

Section: Introductionmentioning

confidence: 99%

Methionine metabolism in chronic liver diseases: an update on molecular mechanism and therapeutic implication

Wang

Liang

et al. 2020

Sig Transduct Target Ther

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As one of the bicyclic metabolic pathways of one-carbon metabolism, methionine metabolism is the pivot linking the folate cycle to the transsulfuration pathway. In addition to being a precursor for glutathione synthesis, and the principal methyl donor for nucleic acid, phospholipid, histone, biogenic amine, and protein methylation, methionine metabolites can participate in polyamine synthesis. Methionine metabolism disorder can aggravate the damage in the pathological state of a disease. In the occurrence and development of chronic liver diseases (CLDs), changes in various components involved in methionine metabolism can affect the pathological state through various mechanisms. A methionine-deficient diet is commonly used for building CLD models. The conversion of key enzymes of methionine metabolism methionine adenosyltransferase (MAT) 1 A and MAT2A/MAT2B is closely related to fibrosis and hepatocellular carcinoma. In vivo and in vitro experiments have shown that by intervening related enzymes or downstream metabolites to interfere with methionine metabolism, the liver injuries could be reduced. Recently, methionine supplementation has gradually attracted the attention of many clinical researchers. Most researchers agree that adequate methionine supplementation can help reduce liver damage. Retrospective analysis of recently conducted relevant studies is of profound significance. This paper reviews the latest achievements related to methionine metabolism and CLD, from molecular mechanisms to clinical research, and provides some insights into the future direction of basic and clinical research.

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“…Thus, alteration in the homeostasis of these trace elements affects the development of liver disease, especially in patients with chronic HBV and HCV infections [21,35,36]. Trace elements are necessary in the treatment of viral hepatitis [34,37]. In our study, the serum Zn level was found to be decreased while the Cu level was increased.…”

Section: Discussionmentioning

confidence: 45%

“…Cu and Zn are trace elements necessary for body metabolism. They are vital enzyme components in cell metabolism and antioxidant defense systems [20,21,34]. Cu and Zn are members of a superoxide dismutase enzyme group (CuZnSOD), which catalyzes the superoxide anion dismutation into H 2 O 2 and oxygen.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of serum proinflammatory cytokines, oxidative stress and some other biochemical markers in chronic viral hepatitis B and C infections

Bayraktar¹

2020

Int J Med Biochem

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Evaluation of serum proinflammatory cytokines, oxidative stress, and other biochemical markers in chronic viral hepatitis B and C infections H epatitis B virus (HBV) and hepatitis C virus (HCV) infections are a global health problem that is endemic in Turkey. These viruses attack the liver and can cause both acute and chronic hepatitis infection [1, 2]. Chronic hepatitis infection presents a major risk for the development of hepatocellular carcinoma [2, 3. 4]. These viruses directly induce oxidative stress Objectives: Infection with the hepatitis B virus (HBV) or the hepatitis C virus (HCV) results in inflammatory responses, which can subsequently lead to severe progressive hepatic disease. Oxidative stress resulting from changes in the activity of antioxidant enzymes and cytokines and causing an excessive accumulation of reactive oxygen species has been identified as a key factor in the pathogenesis and progression of chronic liver inflammation and disease. Minerals such as zinc (Zn) and copper (Cu), which are part of the biochemical structure of some antioxidant enzymes, also play a part in the complicated pathogenesis of HBV and HBC infections. The aim of this study was to investigate the effects of chronic viral HBV and HCV infection on the status of some serum cytokines, antioxidant enzymes, lipid peroxidation, and serum Zn and Cu levels, and to determine if there was any relationship between them. Methods: A total of 78 patients with positive clinical and serological markers of HBV or HCV infection were included: 40 chronic HBV-positive patients, 30 inactive HBV carriers, and 8 chronic HCV-positive patients. Thirty healthy subjects were also included in the study as a control group. The level of serum cytokines tumor necrosis factor-α (TNF-α), interleukin-1β, (IL-1 β), interleukin-2R (IL-2R), interleukin-6 (IL-6), and interleukin-8 (IL-8) was analyzed with a chemiluminescent enzyme immunometric test, the activity of antioxidant enzymes superoxide dismutase (SOD), phospholipid hydroperoxide glutathione peroxidase (GSH-Px), and catalase (CAT) was measured in erythrocytes, and the malondialdehyde (MDA) level was measured in plasma using a fluorescence spectrophotometric method. The serum Zn and Cu concentration was measured with a flame atomic absorption spectrophotometer. Results: Serum cytokine (TNF-α, IL-2R, IL-6, and IL-8) levels were significantly higher in both the HBV-and HCV-positive patient groups when compared with the control group (p<0.05). No statistically significant difference was found in IL-1β values between chronic HBV patients and inactive HBV carriers (p>0.05). Erythrocyte SOD, GSH-Px, and CAT activity, and the serum Zn level were low in both HBV and HCV patients (p<0.05), whereas the plasma MDA and serum Cu levels were found to be significantly elevated (p<0.05). Conclusion: An impaired oxidative stress reaction and increased proinflammatory cytokines were observed in patients infected with chronic HBV or HCV. Chronic viral hepatitis infection was also observed to affect the homeostasis of...

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Changes in Liver Tissue Trace Element Concentrations During Hepatitis B Viral Infection Treatment

Cited by 9 publications

References 17 publications

Toxic metal exposure as a possible risk factor for COVID-19 and other respiratory infectious diseases

Toxic metal exposure as a possible risk factor for COVID-19 and other respiratory infectious diseases

Methionine metabolism in chronic liver diseases: an update on molecular mechanism and therapeutic implication

Evaluation of serum proinflammatory cytokines, oxidative stress and some other biochemical markers in chronic viral hepatitis B and C infections

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