Changes in Lipoprotein Metabolism During Sexual Maturation

Jaross, W; Baehrecke, M; Trübsbach, A; E, Seiler

doi:10.1016/b978-0-08-027357-0.50017-2

Cited by 2 publications

(5 citation statements)

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“…The effect of T, however, seems to be stronger than that of regular physical activity. The inverse relationship between T and HDL-C is consistent with available data (Godsland et al, 1987;Jaross et al, 1981), but not with that of Laskarzewski et al (1983). The latter study found an inverse relationship only in the group with a high level of estradiol (defined as the upper tertile of estradiol levels in a group of 30 adolescent boys).…”

Section: Discussionsupporting

confidence: 93%

“…Regular physical activity is often associated with an increase in the level of high density lipoprotein cholesterol (HDL-C) (Vaccaro and Mahon, 1989;Zonderland, 1985). During puberty in boys, a fall in HDL-C occurs in association with a n increase in testosterone level (T) (Godsland et al, 1987;Jaross et al, 1981). Laskarzewski et al (1983) indicated that changes in lipoproteins in males during adolescence were most readily accounted for by a n interaction among T, estrogens, and adiposity, but Jaross et al (1981) concluded that T in particular and not estrogens, was responsible.…”

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confidence: 97%

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Lipids and apoproteins in relation to participation in organized sport activities and pubertal development in boys

Zonderland

Erich

Dortlandt

et al. 1995

American J Hum Biol

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This study considers changes in the plasma lipid and apoprotein profiles of boys in relation to participation in organized sport activities and to testosterone (T) levels. Fifty boys, aged 9.9 ± 0.6 years (mean ± S.D.), participated in the study. During a 3 year follow-up, the following measurements were taken twice a year: stature, weight, and skinfolds. Blood samples for lipids and apoproteins and sex hormone levels, and information on participation in sport activities were also obtained. No relationship was found between participation in organized sport activities and high density lipoprotein cholesterol (HDL-C) or apoprotein A-I (apo A-I). The changes of the profile over time in more active boys (participation rate > 3 hr/wk) were similar to those of less active boys (participation rate < 1 hr/wk) (MANOVA, repeated measures, not significant.) Consistent relationships between sex hormones and lipids and apoproteins were restricted to T with total cholesterol (TC), HDL-C, and apo A-I, respectively. The common variance ranged from 5.8% (r ) to 18.5% (r ) (P ⩽ 0.05.) When the boys who reached advanced puberty during the follow-up period (n = 21) were studied apart from those who did not (n =29), differences were found in TC, apo A-I, and HDL-C, TC decreased from 4.6 ± 0.65 to 4.3 ± 0.58 mmol/l in the more advanced pubertal boys, and increased from 4.6 ± 0.90 to 4.8 ± 0.79 mmol/l in the others; apo A-I decreased from 185 ± to 28.3 to 156 ± 20.4 mg/dl and from 179 ± 20.6 to 176 ± 27.7 mg/dl, respectively (MANOVA, repeated measures, P ⩽ 0.05) HDL-C was lower in advanced pubertal boys at the end of follow-up (1.4 ± 0.33 and 1.7 ± 0.38 mmol/l, respectivel; P ⩽ 0.05). The lack of a relationship with regular physical activity may be due to the high levels of HDL-C and apo A-I at the begining of the study. On the other hand, the effect of the increasing T levels on HDL-C and apo A-I may have overwhelmed the presumed effect of regular physical activitiy. © 1995 Wiley-Liss, Inc.

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Section: Discussionsupporting

confidence: 93%

mentioning

confidence: 97%

Lipids and apoproteins in relation to participation in organized sport activities and pubertal development in boys

Zonderland

Erich

Dortlandt

et al. 1995

American J Hum Biol

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“…The relationship between sexual maturation and plasma lipids was studied in several large investigations but often without measuring sex hormone profiles (2,18). Jaross et al (12) compared the lipid profile in girls and boys before and after puberty in relation to the changes in T and E-2 levels, Before puberty, the levels of HDL-C and of TG were comparable in boys and girls. Thereafter, the TG level was elevated a little in boys, and in the girls, no change was observed.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, it might be concluded that the changes in HDL-C during puberty are not likely to be due to extrogens. They seem to depend on T (12). The biochemical mechanisms explicating sex hormones-lipoprotein interactions in vivo remain to be clarified, expecially considering the fact that in adult men, endogenous I levels are found to be correlated positively with HDL-C and inversely with TG (10,17).…”

Section: Discussionmentioning

confidence: 99%

“…Administration of estrogens is found to elevate the levels of HDL-C and apo A-I (23), while androgens have the opposite effects (1,11,25). Therefore, testosterone (T) is supposed to be responsible for the decrease in HDL-C during and after puberty in boys (2,12), while in girls, the rising estrogen levels seem to overrule the effect of T, which results in a moderate increase in HDL-C after puberty (12). In a previous study (20), prepubertal girl swimmers were found to have higher levels of T, androstenedione (A), and estrone (E-l) than prepubertal female gymnasts.…”

Section: Introductionmentioning

confidence: 99%

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Plasma Lipoprotein Profile in Relation to Sex Hormones in Premenarcheal Athletes

Zonderland¹,

Erich²,

Peltenburg³

et al. 1986

Int J Sports Med

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Physical activity of an endurance nature is supposed to affect the lipoprotein profile in adults as well as in children. When examining this profile in premenarcheal athletes, regard has to be paid to an interfering effect of the rising sex hormone levels due to puberty. Therefore, the purpose of this study was to investigate the plasma lipoprotein levels of premenarcheal athletes in relation to their sex hormone profile. Thirty-six elite gymnasts, 21 recreational gymnasts, 27 girl swimmers, and 25 very little active control girls participated. Their age was about 12 years. The sex hormone profiles of all groups were similar. The swimmers had the lowest level of TC, LDL-C, and TG (P less than or equal to 0.05), and apo A-I was elevated in this group as compared with the others (P less than or equal to 0.05). HDL-C was highest in the recreational gymnasts (P less than or equal to 0.05). The elite group and the control group had similar lipoprotein profiles. After adjustment for T and E-2, no change in variance of the lipoproteins was found. A low correlation existed between apo A-I, E-2, and T (P less than or equal to 0.05). Thus, in this pediatric population, the sex hormones did not play a significant role relative to the levels of plasma lipids or apo A-I. As the body composition correlated very weakly with TG, it is tentative to conclude that the variance found in the lipoprotein profile might be due to differences in physical activity. Moreover, genetic factors may have contributed to the variance.

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Changes in Lipoprotein Metabolism During Sexual Maturation

Cited by 2 publications

References 12 publications

Lipids and apoproteins in relation to participation in organized sport activities and pubertal development in boys

Lipids and apoproteins in relation to participation in organized sport activities and pubertal development in boys

Plasma Lipoprotein Profile in Relation to Sex Hormones in Premenarcheal Athletes

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